5-HIAA as a Potential Biological Marker for Neurological and Psychiatric Disorders

Hridya Jayamohananan ¹, Maneesha Kalappurackal Manoj Kumar ¹, Aneesh T P ¹ *

Cited by CrossRef: 49

1- Wakeford A, Nye J, Grieb Z, Voisin D, Mun J, Huhman K, Albers E, Michopoulos V. Sex influences the effects of social status on socioemotional behavior and serotonin neurochemistry in rhesus monkeys. Biol Sex Differ. 2023;14(1) [Crossref]

2- Da Silva R, Simon N, Dos Santos A, Olegário G, Da Silva J, Sousa N, Corbacho M, de Melo F. Personalized medicine: Clinical oncology on molecular view of treatment. World J Clin Oncol. 2024;15(8):992 [Crossref]

3- Dono A, Patrizz A, McCormack R, Putluri N, Ganesh B, Kaur B, McCullough L, Ballester Y, Esquenazi Y. Glioma induced alterations in fecal short-chain fatty acids and neurotransmitters. CNS Oncol. 2020;9(2) [Crossref]

4- Bauer E, Agbemafle I, Reddy M, Clark P. Edible insects prevent changes to brain monoamine profiles from malnourishment in weaned rats. Nutritional Neuroscience. 2023;26(9):875 [Crossref]

5- Fomin A, Sergeeva S. The Role of the Serotonin Pathway of Tryptophan Metabolism in the Development of Neuroinflammation in Alzheimer's Disease. jour. 2023;(2):80 [Crossref]

6- Dahchour A, Ward R. Changes in serotonin neurotransmission as assayed by microdialysis after acute, intermittent or chronic ethanol administration and withdrawal. Fundamemntal Clinical Pharma. 2024;38(1):42 [Crossref]

7- Dmitrzak-Weglarz M, Banach E, Bilska K, Narozna B, Szczepankiewicz A, Reszka E, Jablonska E, Kapelski P, Skibinska M, Pawlak J. Molecular Regulation of the Melatonin Biosynthesis Pathway in Unipolar and Bipolar Depression. Front Pharmacol. 2021;12 [Crossref]

8- Mousten I, Sørensen N, Christensen R, Benros M. Cerebrospinal Fluid Biomarkers in Patients With Unipolar Depression Compared With Healthy Control Individuals. JAMA Psychiatry. 2022;79(6):571 [Crossref]

9- Vo D, Trinh K. Emerging Biomarkers in Metabolomics: Advancements in Precision Health and Disease Diagnosis. IJMS. 2024;25(23):13190 [Crossref]

10- Brazienė A, Venclovienė J, Vaičiulis V, Lukšienė D, Tamošiūnas A, Milvidaitė I, Radišauskas R, Bobak M. Relationship between Depressive Symptoms and Weather Conditions. IJERPH. 2022;19(9):5069 [Crossref]

11- Desmet S, Saeys Y, Verstaen K, Dauwe R, Kim H, Niculaes C, Fukushima A, Goeminne G, Vanholme R, Ralph J, Boerjan W, Morreel K. Maize specialized metabolome networks reveal organ-preferential mixed glycosides. Computational and Structural Biotechnology Journal. 2021;19:1127 [Crossref]

12- Hubková B, Valko-Rokytovská M, Čižmárová B, Zábavníková M, Mareková M, Birková A. Tryptophan: Its Metabolism along the Kynurenine, Serotonin, and Indole Pathway in Malignant Melanoma. IJMS. 2022;23(16):9160 [Crossref]

13- Fu R, Jinnah H, Mckay J, Miller A, Felger J, Farber E, Sharma S, Whicker N, Moore R, Franklin D, Letendre S, Anderson A. Cerebrospinal fluid levels of 5-HIAA and dopamine in people with HIV and depression. J Neurovirol. 2023;29(4):440 [Crossref]

14- Bhushan D, Yadav J, Arora A, Agrawal D, Apte A. Validated ultraviolet high-performance liquid chromatography method for post-mortem 5-hydroxy-indoleacetic acid measurement in human cerebrospinal fluid. JLP. 2023;16:58 [Crossref]

15- Ilavská L, Morvová M, Paduchová Z, Muchová J, Garaiova I, Ďuračková Z, Šikurová L, Trebatická J. The kynurenine and serotonin pathway, neopterin and biopterin in depressed children and adolescents: an impact of omega-3 fatty acids, and association with markers related to depressive disorder. A randomized, blinded, prospective study. Front Psychiatry. 2024;15 [Crossref]

16- Fomin A, Sergeeva S. The Role of the Serotonin Pathway of Tryptophan Metabolism in the Development of Neuroinflammation in Alzheimer’s Disease. Adv Gerontol. 2023;13(3):130 [Crossref]

17- Singh A, Sarwat M, Gupta S. Pharmacological Mechanism of Herbal Interventions for Bipolar Disorder. CPD. 2024;30(24):1867 [Crossref]

18- Song L, Zhu N, Hong H. A novel ratiometric fluorescence probe based on flower ball-like metal–organic frameworks for detecting carcinoid biomarker in urine. Inorganic Chemistry Communications. 2023;153:110781 [Crossref]

19- Wang L, Yu L, Liu Z, Che C, Wang Y, Zhao Y, Zhu M, Yang G, Cao A. FMT intervention decreases urine 5-HIAA levels: a randomized double-blind controlled study. Front Med. 2024;11 [Crossref]

20- Fukngoen P, Sivamaruthi B, Sirilun S, Lalitsuradej E, Khongtan S, Peerajan S, Sittiprapaporn P, Chaiyasut C. The Influence of Lactobacillus paracasei HII01 Supplementation on Performance in Attention (Go/No-Go) Tasks and Quinolinic Acid and 5-Hydroxyindoleacetic Acid Levels in Thai Children—A Preliminary Study. Applied Sciences. 2022;12(11):5658 [Crossref]

21- Zhou Y, Liu L, Liu Q, Liu X, Feng M, Wang L, Sun Z, Zhu Y, Zhang X, Jiao C. Dual-Functional Metal–Organic Framework for Luminescent Detection of Carcinoid Biomarkers and High Proton Conduction. Inorg Chem. 2021;60(22):17303 [Crossref]

22- Nogueira Silva Lima M, Boulanger E, Tessier F, Takahashi J. Hibiscus, Rooibos, and Yerba Mate for Healthy Aging: A Review on the Attenuation of In Vitro and In Vivo Markers Related to Oxidative Stress, Glycoxidation, and Neurodegeneration. Foods. 2022;11(12):1676 [Crossref]

23- Ibrahim T, Eissa R, El-Megrab N, El-Nahas H. Morphological characterization of optimized risperidone-loaded in-situ gel forming implants with pharmacokinetic and behavioral assessments in rats. Journal of Drug Delivery Science and Technology. 2021;61:102195 [Crossref]

24- Cini N, Atasoy O, Erdogan M, Yaprak G, Eroglu E, Sirin C, Uyanikgil Y, Erbas O. Investigation of the neuroprotective effect of Granisetron through SV2A and 5-HT3 modulation in a radiation-induced brain injury rat model. Int J Radiat Res. 2023;21(3):435 [Crossref]

25- Boukersi H, Lebaili N, Nosjean A, Samson N, Faure A, Granon S. Effects of water restriction on social behavior and 5-HT neurons density in the dorsal and median raphe nuclei in mice. Behavioural Brain Research. 2021;399:113022 [Crossref]

26- Shin P, Chun S, Kim M, Park S, Kim M, Kwon D, Kim K, Lee H, Choi S. Traditional Korean diet can alter the urine organic acid profile, which may reflect the metabolic influence of the diet. J Nutr Health. 2020;53(3):231 [Crossref]

27- Lin S, Zhou Z, Qi Y, Chen J, Xu G, Shi Y, Yu Z, Li M, Chai K. Depression promotes breast cancer progression by regulating amino acid neurotransmitter metabolism and gut microbial disturbance. Clin Transl Oncol. 2024;26(6):1407 [Crossref]

28- Vencloviene J, Beresnevaite M, Cerkauskaite S, Lopatiene K, Grizas V, Benetis R. The effects of weather on depressive symptoms in patients after cardiac surgery. Psychology, Health & Medicine. 2023;28(3):682 [Crossref]

29- Tatarinova T, Deiss T, Franckle L, Beaven S, Davis J. The Impact of MNRI Therapy on the Levels of Neurotransmitters Associated with Inflammatory Processes. IJMS. 2020;21(4):1358 [Crossref]

30- Jovanovic F, Sudhakar A, Knezevic N. The Kynurenine Pathway and Polycystic Ovary Syndrome: Inflammation as a Common Denominator. Int J�Tryptophan�Res. 2022;15 [Crossref]

31- Fila M, Chojnacki J, Derwich M, Chojnacki C, Pawlowska E, Blasiak J. Urine 5-Hydroxyindoleacetic Acid Negatively Correlates with Migraine Occurrence and Characteristics in the Interictal Phase of Episodic Migraine. IJMS. 2024;25(10):5471 [Crossref]

32- Johnson A, Clark A, Anderson M, Corbin E, Arguelles-Ramos M, Ali A. The Influence of Dietary Synbiotic on Agonistic Behavior, Stress, and Brain Monoamines via Modulation of the Microbiota–Gut–Brain Axis in Laying Hens. Poultry. 2024;3(2):129 [Crossref]

33- Kunčická D, Cmarková N, Ondráčková S, Kačer D, Bermejo Rodriguez D, Valeš K, Svoboda J, Brožka H, Stuchlík A. Serotonin and Effort-Based Decision-Making: Dissociating Behavioral Effects of 8-OH-DPAT and PCPA. Physiol Res. 2024;(5/2024):869 [Crossref]

34- Chatterjee M, Saha S, Sinha S, Mukhopadhyay K. A three-pronged analysis confirms the association of the serotoninergic system with attention deficit hyperactivity disorder. World J Pediatr. 2022;18(12):825 [Crossref]

35- Fu Y, Cheng H. The Influence of Cecal Microbiota Transplantation on Chicken Injurious Behavior: Perspective in Human Neuropsychiatric Research. Biomolecules. 2024;14(8):1017 [Crossref]

36- Min D, Kim B, Ko S, Kim W. Effect and Mechanism of Herbal Medicines on Cisplatin-Induced Anorexia. Pharmaceuticals. 2022;15(2):208 [Crossref]

37- TAŞKIRAN A, CANBOLAT F, YÜCELLİ S, ÇEVRELİ B. Evaluation of the Antidepressant Effect of Propolis in Chronic Unpredictable Mild Stress-Induced Depression Model in Rats. nkmj. 2024;:145 [Crossref]

38- Cui J, Xiao S, Cao Y, Zhang Y, Yang J, Zheng L, Zhao F, Liu X, Liu D, Zhou Z, Wang P. Organophosphate Insecticide Malathion Induces Alzheimer’s Disease-Like Cognitive Impairment in Mice: Evidence of the Microbiota-Gut-Brain Axis. Environ Sci Technol. 2024;58(50):21966 [Crossref]

39- Bhardwaj S, Kaur R, kumari P, Sharma S, Pasricha C, Jamwal N, Singh R, Arora P, Kaur P, Kumar Sahu S, Prabhakar P. A Scoping Review and Preliminary Illustrative Analysis of Biomarkers in Stress-Related Psychiatric Illness: Diagnostic and Prognostic Implications. BIO Web Conf. 2024;86:01039 [Crossref]

40- TAŞKIRAN A, CANBOLAT F, YÜCELLİ S, ÇEVRELİ B. Evaluation of the Antidepressant Effect of Propolis in Chronic Unpredictable Mild Stress-induced Depression Model in Rats. NKTD. 2023;11(2):94 [Crossref]

41- Ying X, Chen J, Tu D, Zhuang Y, Wu D, Shen L. Tetraphenylpyrazine-Based Luminescent Metal–Organic Framework for Chemical Sensing of Carcinoids Biomarkers. ACS Appl Mater Interfaces. 2021;13(5):6421 [Crossref]

42- Chen X, Xu D, Yu J, Song X, Li X, Cui Y. Tryptophan Metabolism Disorder-Triggered Diseases, Mechanisms, and Therapeutic Strategies: A Scientometric Review. Nutrients. 2024;16(19):3380 [Crossref]

43- Afia A, Vila È, MacDowell K, Ormazabal A, Leza J, Haro J, Artuch R, Ramos B, Garcia-Bueno B. Kynurenine pathway in post-mortem prefrontal cortex and cerebellum in schizophrenia: relationship with monoamines and symptomatology. J Neuroinflammation. 2021;18(1) [Crossref]

44- Sharma M, Tiwari V, Chaturvedi S, Wahajuddin M, Shukla S, Panda J. Self-Fluorescent Lone Tryptophan Nanoparticles as Theranostic Agents Against Alzheimer’s Disease. ACS Appl Mater Interfaces. 2022;14(11):13079 [Crossref]

45- Yang Z, Chen Z, Chen L, Xiong G. 5-Hydroxyindoleacetic acid, a new ligand for GPR35, plays an important role in inflammatory disease. ABBS. 2022; [Crossref]

46- Demkiv O, Nogala W, Stasyuk N, Holdynski M, Dimcheva N, Danysh T, Asztemborska M, Gonchar M. Laccase mimetics as sensing elements for amperometric assay of 5-hydroxyindoleacetic acid in urine. Bioelectrochemistry. 2025;161:108839 [Crossref]

47- Correia A, Duarte D, Silva I, Reguengo H, Oliveira J, Vale N. Serotonin after β-Adrenoreceptors’ Exposition: New Approaches for Personalized Data in Breast Cancer Cells. JPM. 2021;11(10):954 [Crossref]

48- Zul Aznal A, Mohamad Nor Hazalin N, Hassan Z, Mat N, Chear N, Teh L, Salleh M, Suhaimi F. Adolescent kratom exposure affects cognitive behaviours and brain metabolite profiles in Sprague-Dawley rats. Front Pharmacol. 2022;13 [Crossref]

49- Fu Y, Hu J, Erasmus M, Johnson T, Cheng H. Effects of early-life cecal microbiota transplantation from divergently selected inbred chicken lines on growth, gut serotonin, and immune parameters in recipient chickens. Poultry Science. 2022;101(7):101925 [Crossref]