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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2019;9(3): 409-415. doi: 10.15171/apb.2019.048
PMID: 31592135        PMCID: PMC6773937

Research Article

Anti-tumor Effect of Quercetin Loaded Chitosan Nanoparticles on Induced Colon Cancer in Wistar Rats

Jalil Rashedi 1, Amir Ghorbani Haghjo 2 * , Mehran Mesgari Abbasi 3 ORCID, Ali Dastranj Tabrizi 4, Shadi Yaqoubi 5, Davoud Sanajou 1, Zahra Ashrafi Jigheh 1, Ali Namvaran 6, Ali Mohammadi 7, Jalal Mohammadi Khoshraj 8, Behzad Baradaran 9 * ORCID

Cited by CrossRef: 36

1- Safarpour S, Safarpour S, Akbar Moghadamnia A, Kazemi S, Ebrahimpour A, Shirafkan F. The protective effects of silymarin nanoemulsion on 5-fluorouracil-induced gastrointestinal toxicity in rats. Saudi Pharmaceutical Journal. 2023;31(8):101672 [Crossref]
2- Bakr A, El-Shiekh R, Mahmoud M, Khalil H, Alyami M, Alyami H, Galal O, Mansour D. Efficacy of Quercetin and Quercetin Loaded Chitosan Nanoparticles Against Cisplatin-Induced Renal and Testicular Toxicity via Attenuation of Oxidative Stress, Inflammation, and Apoptosis. Pharmaceuticals. 2024;17(10):1384 [Crossref]
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5- Feizolahi F, Arabzadeh E, Sarshin A, Falahi F, Dehghannayeri Z, Ali Askari A, Wong A, Aghaei F, Zargani M. Effects of Exercise Training and L-Arginine Loaded Chitosan Nanoparticles on Hippocampus Histopathology, β-Secretase Enzyme Function, APP, Tau, Iba1and APOE-4 mRNA in Aging Rats. Neurotox Res. 2024;42(2) [Crossref]
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17- Mogadem A, El-Kady H, Eskandrani A, Abou-Taleb B, Salah S, Samir N, Bakr B, Elwakil B. Probiotic bacteria combined with curcumin-loaded chitosan nanoparticles as a promising anti-colorectal cancer agent. Journal of Drug Delivery Science and Technology. 2025;114:107415 [Crossref]
18- Zhao X, Deng Y, Xue X, Liao L, Zhou M, Peng C, Li Y. Research Progress of Quercetin Delivery Systems. CPD. 2022;28(9):727 [Crossref]
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20- Mirazimi S, Dashti F, Tobeiha M, Shahini A, Jafari R, Khoddami M, Sheida A, EsnaAshari P, Aflatoonian A, Elikaii F, Zakeri M, Hamblin M, Aghajani M, Bavarsadkarimi M, Mirzaei H. Application of Quercetin in the Treatment of Gastrointestinal Cancers. Front Pharmacol. 2022;13 [Crossref]
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22- Maugeri A, Calderaro A, Patanè G, Navarra M, Barreca D, Cirmi S, Felice M. Targets Involved in the Anti-Cancer Activity of Quercetin in Breast, Colorectal and Liver Neoplasms. IJMS. 2023;24(3):2952 [Crossref]
23- Elmorsy E, Alqahtani N, Alenezi Y, Abbas M, Atta M, Aggour A, Fawzy M, Elshopakey G. Nutritional nanotherapy with quercetin-loaded chitosan nanoparticles ameliorates imidacloprid-induced liver toxicity through antioxidant, anti-Inflammatory, and genoprotective mechanisms. Naunyn-Schmiedeberg's Arch Pharmacol. 2026;399(5):6623 [Crossref]
24- Mechchate H, de Castro Alves C, Es-safi I, Amaghnouje A, Jawhari F, Costa de Oliveira R, de Freitas Gomes A, Conte R, Soares Pontes G, Bousta D, Grafov A. Antileukemic, Antioxidant, Anti-Inflammatory and Healing Activities Induced by a Polyphenol-Enriched Fraction Extracted from Leaves of Myrtus communis L.. Nutrients. 2022;14(23):5055 [Crossref]
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26- Tiwari P, Mishra K. Role of Plant-Derived Flavonoids in Cancer Treatment. Nutrition and Cancer. 2023;75(2):430 [Crossref]
27- Ahmadi M, Pourmadadi M, Ghorbanian S, Yazdian F, Rashedi H. Ultra pH-sensitive nanocarrier based on Fe2O3/chitosan/montmorillonite for quercetin delivery. International Journal of Biological Macromolecules. 2021;191:738 [Crossref]
28- Malik M, Anwar F, Dini L, Alamri A, Al Fatease A, Lahiq A, Alqahtani S, Jin S, Choi H, Din F. Palbociclib- and regorafenib-loaded nanomicelles for the treatment of non-small cell lung cancer: pharmacokinetic and antitumor evaluations. J Pharm Investig. 2025; [Crossref]
29- Garbati P, Picco C, Magrassi R, Signorello P, Cacopardo L, Dalla Serra M, Faticato M, De Luca M, Balestra F, Scavo M, Viti F. Targeting the Gut: A Systematic Review of Specific Drug Nanocarriers. Pharmaceutics. 2024;16(3):431 [Crossref]
30- Pattnaik A, Pati S, Samal S. Chitosan-Polyphenol Conjugates for Human Health. Life. 2022;12(11):1768 [Crossref]
31- Jaiswal S, Dutta P, Kumar S, Chawla R. Chitosan modified by organo-functionalities as an efficient nanoplatform for anti-cancer drug delivery process. Journal of Drug Delivery Science and Technology. 2021;62:102407 [Crossref]
32- Faraji G, Moeini P, Rajabi Torkamani A, Shafiee H, Nazemalhosseini Mojarad E. Nano-particles’ benefits for colon cancer effective therapy: a review of recent advancements and clinical trials. International Journal of Polymeric Materials and Polymeric Biomaterials. 2024;73(11):987 [Crossref]
33- Smeu A, Marcovici I, Dehelean C, Dumitrel S, Borza C, Lighezan R. Flavonoids and Flavonoid-Based Nanopharmaceuticals as Promising Therapeutic Strategies for Colorectal Cancer—An Updated Literature Review. Pharmaceuticals. 2025;18(2):231 [Crossref]
34- Mu W, Yestekbayeva D, Twum B, Wan M. A comprehensive review of six dietary polyphenols in colorectal cancer: Pharmacokinetics, mechanism and therapeutic potentials. Phytomedicine. 2025;149:157509 [Crossref]
35- Das P, Ghosh S, Ashashainy V, Nayak B. Augmentation of anti-proliferative efficacy of quercetin encapsulated chitosan nanoparticles by induction of cell death via mitochondrial membrane permeabilization in oral cancer. International Journal of Biological Macromolecules. 2023;250:126151 [Crossref]
36- Hassani S, Maghsoudi H, Fattahi F, Malekinejad F, Hajmalek N, Sheikhnia F, Kheradmand F, Fahimirad S, Ghorbanpour M. Flavonoids nanostructures promising therapeutic efficiencies in colorectal cancer. International Journal of Biological Macromolecules. 2023;241:124508 [Crossref]
37- Gunasangkaran G, Ravi A, Arumugam V, Muthukrishnan S. Preparation, Characterization, and Anticancer Efficacy of Chitosan, Chitosan Encapsulated Piperine and Probiotics (Lactobacillus plantarum (MTCC-1407), and Lactobacillus rhamnosus (MTCC-1423) Nanoparticles. BioNanoSci. 2022;12(2):527 [Crossref]
38- Joshi H, Gupta D, Kaur G, Singh T, Ramniwas S, Sak K, Aggarwal D, Chhabra R, Gupta M, Saini A, Tuli H. Nanoformulations of quercetin for controlled delivery: a review of preclinical anticancer studies. Naunyn-Schmiedeberg's Arch Pharmacol. 2023;396(12):3443 [Crossref]
39- Babaalizadeh B, Osanloo M, Tavassoli A, Zarenezhad E, Niknia S, Miladpour B. Hepatoprotective Effects of Quercetin‐Chitosan Nanoparticles on Nonalcoholic Fatty Liver Disease: In Vivo Study. Food Science & Nutrition. 2026;14(4) [Crossref]
40- Rath D, Kar B, Pattnaik G, Bhukta P, Rout R. Phyto-Flavonoids in Cancer Therapy: Emerging Insights and Future Perspectives. Foods Nutr Food Sci 2026;. 2026;1(14):1 [Crossref]
41- Soliman A, Mahmoud B, Eldin Z, El-Shahawy A, Abdel-Gabbar M. Optimized synthesis characterization and protective activity of quercetin and quercetin–chitosan nanoformula against cardiotoxicity that was induced in male Wister rats via anticancer agent: doxorubicin. Cancer Nano. 2023;14(1) [Crossref]
42- Unnikrishnan Meenakshi D, Narde G, Ahuja A, Al Balushi K, Francis A, Khan S. Therapeutic Applications of Nanoformulated Resveratrol and Quercetin Phytochemicals in Colorectal Cancer—An Updated Review. Pharmaceutics. 2024;16(6):761 [Crossref]
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