Anti-tumor Effect of Quercetin Loaded Chitosan Nanoparticles on Induced Colon Cancer in Wistar Rats

Jalil Rashedi ¹, Amir Ghorbani Haghjo ² * , Mehran Mesgari Abbasi ³ , Ali Dastranj Tabrizi ⁴, Shadi Yaqoubi ⁵, Davoud Sanajou ¹, Zahra Ashrafi Jigheh ¹, Ali Namvaran ⁶, Ali Mohammadi ⁷, Jalal Mohammadi Khoshraj ⁸, Behzad Baradaran ⁹ *

Cited by CrossRef: 29

1- Mechchate H, de Castro Alves C, Es-safi I, Amaghnouje A, Jawhari F, Costa de Oliveira R, de Freitas Gomes A, Conte R, Soares Pontes G, Bousta D, Grafov A. Antileukemic, Antioxidant, Anti-Inflammatory and Healing Activities Induced by a Polyphenol-Enriched Fraction Extracted from Leaves of Myrtus communis L.. Nutrients. 2022;14(23):5055 [Crossref]

2- Tiwari P, Mishra K. Role of Plant-Derived Flavonoids in Cancer Treatment. Nutrition and Cancer. 2023;75(2):430 [Crossref]

3- Safarpour S, Safarpour S, Akbar Moghadamnia A, Kazemi S, Ebrahimpour A, Shirafkan F. The protective effects of silymarin nanoemulsion on 5-fluorouracil-induced gastrointestinal toxicity in rats. Saudi Pharmaceutical Journal. 2023;31(8):101672 [Crossref]

4- Ahmadi M, Pourmadadi M, Ghorbanian S, Yazdian F, Rashedi H. Ultra pH-sensitive nanocarrier based on Fe2O3/chitosan/montmorillonite for quercetin delivery. International Journal of Biological Macromolecules. 2021;191:738 [Crossref]

5- Kurt A, Olutas E, Avcioglu F, Karakuş H, Sungur M, Kara Oztabag C, Yıldırım M. Quercetin- and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles: one-pot synthesis, characterization, and anticancer and antibacterial activities. Beilstein J Nanotechnol. 2023;14:362 [Crossref]

6- Feizolahi F, Arabzadeh E, Sarshin A, Falahi F, Dehghannayeri Z, Ali Askari A, Wong A, Aghaei F, Zargani M. Effects of Exercise Training and L-Arginine Loaded Chitosan Nanoparticles on Hippocampus Histopathology, β-Secretase Enzyme Function, APP, Tau, Iba1and APOE-4 mRNA in Aging Rats. Neurotox Res. 2024;42(2) [Crossref]

7- Garbati P, Picco C, Magrassi R, Signorello P, Cacopardo L, Dalla Serra M, Faticato M, De Luca M, Balestra F, Scavo M, Viti F. Targeting the Gut: A Systematic Review of Specific Drug Nanocarriers. Pharmaceutics. 2024;16(3):431 [Crossref]

8- Zargani M, Hatami Nasab Z, Feizolahi F, Arabzadeh E. Swimming exercise with l-arginine coated nanoparticles supplementation upregulated HAND2 and TBX5 expression in the cardiomyocytes of aging male rats. Biogerontology. 2022;23(4):473 [Crossref]

9- Pattnaik A, Pati S, Samal S. Chitosan-Polyphenol Conjugates for Human Health. Life. 2022;12(11):1768 [Crossref]

10- Jaiswal S, Dutta P, Kumar S, Chawla R. Chitosan modified by organo-functionalities as an efficient nanoplatform for anti-cancer drug delivery process. Journal of Drug Delivery Science and Technology. 2021;62:102407 [Crossref]

11- Faraji G, Moeini P, Rajabi Torkamani A, Shafiee H, Nazemalhosseini Mojarad E. Nano-particles’ benefits for colon cancer effective therapy: a review of recent advancements and clinical trials. International Journal of Polymeric Materials and Polymeric Biomaterials. 2023;:1 [Crossref]

12- Azeem M, Hanif M, Mahmood K, Ameer N, Chughtai F, Abid U. An insight into anticancer, antioxidant, antimicrobial, antidiabetic and anti-inflammatory effects of quercetin: a review. Polym Bull. 2023;80(1):241 [Crossref]

13- Safarpour S, Safarpour S, Ebrahimpour A, Hosseini S, Pirzadeh M, Moghadamnia A, Kazemi S. Quercetin nanoparticle ameliorates 5-fluorouracil-induced testicular damage in mice: A biochemical and histological study. South African Journal of Botany. 2024;164:200 [Crossref]

14- Das P, Ghosh S, Ashashainy V, Nayak B. Augmentation of anti-proliferative efficacy of quercetin encapsulated chitosan nanoparticles by induction of cell death via mitochondrial membrane permeabilization in oral cancer. International Journal of Biological Macromolecules. 2023;250:126151 [Crossref]

15- Hassani S, Maghsoudi H, Fattahi F, Malekinejad F, Hajmalek N, Sheikhnia F, Kheradmand F, Fahimirad S, Ghorbanpour M. Flavonoids nanostructures promising therapeutic efficiencies in colorectal cancer. International Journal of Biological Macromolecules. 2023;241:124508 [Crossref]

16- Sabourian P, Ji J, Lotocki V, Moquin A, Hanna R, Frounchi M, Maysinger D, Kakkar A. Facile design of autogenous stimuli-responsive chitosan/hyaluronic acid nanoparticles for efficient small molecules to protein delivery. J Mater Chem B. 2020;8(32):7275 [Crossref]

17- Gunasangkaran G, Ravi A, Arumugam V, Muthukrishnan S. Preparation, Characterization, and Anticancer Efficacy of Chitosan, Chitosan Encapsulated Piperine and Probiotics (Lactobacillus plantarum (MTCC-1407), and Lactobacillus rhamnosus (MTCC-1423) Nanoparticles. BioNanoSci. 2022;12(2):527 [Crossref]

18- Kaur S, Goyal A, Rai A, Sharma A, Ugoeze K, Singh I. Quercetin nanoformulations: recent advancements and therapeutic applications. Adv Nat Sci: Nanosci Nanotechnol. 2023;14(3):033002 [Crossref]

19- Joshi H, Gupta D, Kaur G, Singh T, Ramniwas S, Sak K, Aggarwal D, Chhabra R, Gupta M, Saini A, Tuli H. Nanoformulations of quercetin for controlled delivery: a review of preclinical anticancer studies. Naunyn-Schmiedeberg's Arch Pharmacol. 2023;396(12):3443 [Crossref]

20- Zhao X, Deng Y, Xue X, Liao L, Zhou M, Peng C, Li Y. Research Progress of Quercetin Delivery Systems. CPD. 2022;28(9):727 [Crossref]

21- Mahmoud N, Hassanein E, Bakhite E, Shaltout E, Sayed A. Apocynin and its chitosan nanoparticles attenuated cisplatin-induced multiorgan failure: Synthesis, characterization, and biological evaluation. Life Sciences. 2023;314:121313 [Crossref]

22- Mirazimi S, Dashti F, Tobeiha M, Shahini A, Jafari R, Khoddami M, Sheida A, EsnaAshari P, Aflatoonian A, Elikaii F, Zakeri M, Hamblin M, Aghajani M, Bavarsadkarimi M, Mirzaei H. Application of Quercetin in the Treatment of Gastrointestinal Cancers. Front Pharmacol. 2022;13 [Crossref]

23- Soliman A, Mahmoud B, Eldin Z, El-Shahawy A, Abdel-Gabbar M. Optimized synthesis characterization and protective activity of quercetin and quercetin–chitosan nanoformula against cardiotoxicity that was induced in male Wister rats via anticancer agent: doxorubicin. Cancer Nano. 2023;14(1) [Crossref]

24- Liu Y, Zhang H, Cui H, Zhang F, Zhao L, Liu Y, Meng Q. Combined and targeted drugs delivery system for colorectal cancer treatment: Conatumumab decorated, reactive oxygen species sensitive irinotecan prodrug and quercetin co-loaded nanostructured lipid carriers. Drug Delivery. 2022;29(1):342 [Crossref]

25- Sabit H, Abdel-Hakeem M, Shoala T, Abdel-Ghany S, Abdel-Latif M, Almulhim J, Mansy M. Nanocarriers: A Reliable Tool for the Delivery of Anticancer Drugs. Pharmaceutics. 2022;14(8):1566 [Crossref]

26- Visan R, Leonties A, Anastasescu M, Angelescu D. Towards understanding the interaction of quercetin with chitosan-phytate complex: An experimental and computational investigation. Journal of Molecular Liquids. 2023;380:121673 [Crossref]

27- Maugeri A, Calderaro A, Patanè G, Navarra M, Barreca D, Cirmi S, Felice M. Targets Involved in the Anti-Cancer Activity of Quercetin in Breast, Colorectal and Liver Neoplasms. IJMS. 2023;24(3):2952 [Crossref]

28- Di Santo M, D’ Antoni C, Domínguez Rubio A, Alaimo A, Pérez O. Chitosan-tripolyphosphate nanoparticles designed to encapsulate polyphenolic compounds for biomedical and pharmaceutical applications − A review. Biomedicine & Pharmacotherapy. 2021;142:111970 [Crossref]

29- Li N, Wang J. Quercetin induces cytotoxicity and apoptosis, reduces metastasis and drug resistance in oral cancer cells. 2023;0(0) [Crossref]