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Adv Pharm Bull. 2020;10(3): 423-429. doi: 10.34172/apb.2020.051

PMID: 32665901 PMCID: PMC7335995

Research Article

Design, Synthesis and Biological Evaluation of Novel Piperazinone Derivatives as Cytotoxic Agents

Saeed Ghasemi ¹ , Simin Sharifi ², Javid Shahbazi Mojarrad ³ *

Cited by CrossRef: 7

1- Kumari N, Yadav A, Sankpal S, Murugavel S, Lakshmanan D, Kant R. Synthesis, crystal structure, quantum chemical computation and molecular docking analysis of 1-(4(tert-butyl)-4-methoxy-[1,1-biphenyl]-4-yl) ethenone. J IRAN CHEM SOC. 2024;21(6):1669 [Crossref]

2- Azmian Moghadam F, Evazalipour M, Kefayati H, Ghasemi S. 6,7-Disubstituted-4-anilinoquinazoline: Design, Synthesis and Anticancer Activity as a Novel Series of Potent Anticancer Agents . Pharm Sci. 2020;27(2):209 [Crossref]

3- Azmian Moghadam F, Dabirian S, Ebrahimi Tavani A, Alipour P, Mojabi M, Evazalipour M, Yousefbeyk F, Ghasemi S. Application of a Deep Eutectic Solvent for the Synthesis of Novel Imidazole-Containing Quinazoline Derivatives as Potent Cytotoxic Agents . Pharm Sci. 2024;30(2):215 [Crossref]

4- Yousefbeyk F, Dabirian S, Ghanbarzadeh S, Eghbali Koohi D, Yazdizadeh P, Ghasemi S. Green synthesis of silver nanoparticles from Stachys byzantina K. Koch: characterization, antioxidant, antibacterial, and cytotoxic activity. Particulate Science and Technology. 2022;40(2):219 [Crossref]

5- Moghadam F, Dabirian S, Dogaheh M, Mojabi M, Yousefbeyk F, Ghasemi S. Novel 4-Anilinoquinazoline Derivatives as Potent Anticancer Agents: Design, Synthesis, Cytotoxic Activity, and Docking Study. Aust J Chem. 2021;74(10):730 [Crossref]

6- Xia M, Yu L, Yan Z, Wang Y, Zhang L, Miao G, Li S. FTase inhibitors and cancer: prospects for use in targeted therapies. Med Chem Res. 2024;33(1):21 [Crossref]

7- Zarenezhad E, Behmard E, Karami R, Behrouz S, Marzi M, Ghasemian A, Soltani Rad M. The antibacterial and anti-biofilm effects of novel synthetized nitroimidazole compounds against methicillin-resistant Staphylococcus aureus and carbapenem-resistant Escherichia coli and Klebsiella pneumonia in vitro and in silico. BMC Chemistry. 2024;18(1) [Crossref]

8- Prajapati V, Singh A, Kumar A, Singh H, Pathak P, Grishina M, Kumar V, Khalilullah H, Verma A, Kumar P. Structural insights, regulation, and recent advances of RAS inhibitors in the MAPK signaling cascade: a medicinal chemistry perspective. RSC Med Chem. 2025; [Crossref]

9- Yu L, Wang Y, Yan Z, Zhang L, Li S. Development of erythrina-based PARP-1/FTase dual-target inhibitors against lung cancer epithelial-mesenchymal transition (EMT) in vivo and in vitro. Bioorganic Chemistry. 2024;148:107480 [Crossref]