Preparation and Characterization of Silk Fibroin Nanoparticles as a Potential Drug Delivery System for 5-Fluorouracil

Hamid Rahmani ^1,2 , Ali Fattahi ³ * , Komail Sadrjavadi ¹ * , Salar Khaledian ³ , Yalda Shokoohinia ¹

Cited by CrossRef: 34

1- Eivazzadeh-Keihan R, Mohammadi A, Aghamirza Moghim Aliabadi H, Kashtiaray A, Bani M, Karimi A, Maleki A, Mahdavi M. A novel ternary magnetic nanobiocomposite based on tragacanth-silk fibroin hydrogel for hyperthermia and biological properties. Sci Rep. 2024;14(1) [Crossref]

2- Du S, Wei Y, Tan Y, Li Y, Li J, Wu T, Han L, Wang M, Ahmed S, Zhou W, Wu L, Zhang T. Self-assembled mesoporous particles of Antheraea pernyi silk fibroin for encapsulation and sustained release of 5-fluorouracil. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2023;673:131772 [Crossref]

3- Yousefi M, Rad M, Shakibazadeh R, Ghodrati L, Kachoie M. Simulating a heteroatomic CBN fullerene-like nanocage towards the drug delivery of fluorouracil. Molecular Simulation. 2022;48(14):1284 [Crossref]

4- Hashemi A, Naseri M, Rahimi M, Shahidi M, Shirmohammadi N, Chireh M, Khodaee A. In vitro and in silico investigations by two new pH sensitive magnetic ferrate nanocarriers for delivery of 5-fluorouracil and chlorambucil. J Sol-Gel Sci Technol. 2023;106(1):54 [Crossref]

5- Sreena R, Nathanael A. Biodegradable Biopolymeric Nanoparticles for Biomedical Applications-Challenges and Future Outlook. Materials. 2023;16(6):2364 [Crossref]

6- Mahdieh A, Yeganeh H, Sande S, Nyström B. Design of novel polyurethane-based ionene nanocarriers for cancer therapy: Synthesis, in-vitro, and in-vivo studies. International Journal of Pharmaceutics. 2023;635:122768 [Crossref]

7- Rajaei M, Rashedi H, Yazdian F, Navaei-Nigjeh M, Rahdar A, Díez-Pascual A. Chitosan/agarose/graphene oxide nanohydrogel as drug delivery system of 5-fluorouracil in breast cancer therapy. Journal of Drug Delivery Science and Technology. 2023;82:104307 [Crossref]

8- Hudita A, Radu I, Galateanu B, Ginghina O, Herman H, Balta C, Rosu M, Zaharia C, Costache M, Tanasa E, Velonia K, Tsatsakis A, Hermenean A. Bioinspired silk fibroin nano-delivery systems protect against 5-FU induced gastrointestinal mucositis in a mouse model and display antitumor effects on HT-29 colorectal cancer cells in vitro. Nanotoxicology. 2021;:1 [Crossref]

9- Leung K, Shirazi S, Cooper L, Ravindran S. Biomaterials and Extracellular Vesicle Delivery: Current Status, Applications and Challenges. Cells. 2022;11(18):2851 [Crossref]

10- Jeshvaghani P, Pourmadadi M, Yazdian F, Rashedi H, Khoshmaram K, Nigjeh M. Synthesis and characterization of a novel, pH-responsive sustained release nanocarrier using polyethylene glycol, graphene oxide, and natural silk fibroin protein by a green nano emulsification method to enhance cancer treatment. International Journal of Biological Macromolecules. 2023;226:1100 [Crossref]

11- Singh M, Jana B, Pal P, Singha I, Rajkumari A, Chowrasia P, Nath V, Mazumder B. Nanoparticles in pancreatic cancer therapy: a detailed and elaborated review on patent literature. Expert Opinion on Therapeutic Patents. 2023;33(10):681 [Crossref]

12- Vafapour F, Bagheri F, Farokhi M. Development of pH-Sensitive Alendronate-Decorated Silk Fibroin/ Alginate Nanoparticles for Active Targeting of Doxorubicin to Bone Cancers. J Clust Sci. 2024;35(5):1317 [Crossref]

13- Gagliardi A, Ambrosio N, Voci S, Salvatici M, Fresta M, Cosco D. Easy preparation, characterization and cytotoxic investigation of 5-Fluorouracil-loaded zein/sericin nanoblends. Journal of Molecular Liquids. 2022;366:120344 [Crossref]

14- Ferrera F, Resaz R, Bari E, Fenoglio D, Mastracci L, Miletto I, Modena A, Perteghella S, Sorlini M, Segale L, Filaci G, Torre M, Giovannelli L. Silk fibroin nanoparticles for locoregional cancer therapy: Preliminary biodistribution in a murine model and microfluidic GMP-like production. International Journal of Biological Macromolecules. 2024;282:137121 [Crossref]

15- Hudiță A, Radu I, Zaharia C, Ion A, Ginghină O, Gălățeanu B, Măruțescu L, Grama F, Tsatsakis A, Gurevich L, Costache M. Bio- and Hemo-Compatible Silk Fibroin PEGylated Nanocarriers for 5-Fluorouracil Chemotherapy in Colorectal Cancer: In Vitro Studies. Pharmaceutics. 2021;13(5):755 [Crossref]

16- Zhang S, Shah S, Basharat K, Qamar S, Raza A, Mohamed A, Bilal M, Iqbal H. Silk-based nano-hydrogels for futuristic biomedical applications. Journal of Drug Delivery Science and Technology. 2022;72:103385 [Crossref]

17- Ghalei S, Handa H. A review on antibacterial silk fibroin-based biomaterials: current state and prospects. Materials Today Chemistry. 2022;23:100673 [Crossref]

18- Safaiee R, Aminzadeh H, Sardarian A, Nasresfahani S, Sheikhi M. A high loading nanocarrier for the 5-fluorouracil anticancer drug based on chloromethylated graphene. Phys Chem Chem Phys. 2024;26(7):6410 [Crossref]

19- Florczak A, Grzechowiak I, Deptuch T, Kucharczyk K, Kaminska A, Dams-Kozlowska H. Silk Particles as Carriers of Therapeutic Molecules for Cancer Treatment. Materials. 2020;13(21):4946 [Crossref]

20- Baci G, Baciu E, Cucu A, Muscă A, Giurgiu A, Moise A, Zăhan M, Dezmirean D. Sericultural By-Products: The Potential for Alternative Therapy in Cancer Drug Design. Molecules. 2023;28(2):850 [Crossref]

21- Rajendra P, Nidamanuri B, Balan A, Venkatachalam S, Jawahar N. A review on structure, preparation and applications of silk fibroin-based nano-drug delivery systems. J Nanopart Res. 2022;24(7) [Crossref]

22- Florczak A, Deptuch T, Kucharczyk K, Dams-Kozlowska H. Systemic and Local Silk-Based Drug Delivery Systems for Cancer Therapy. Cancers. 2021;13(21):5389 [Crossref]

23- Pourmadadi M, Poorkhalili P, Sorourian M, Sorourian G, Ghaderi R, Mehrabi M, Ajalli N. The smart nanocarrier containing zein/starch co-biopolymers enhanced by graphitic carbon nitride; exploring opportunities in brain cancer treatment. International Journal of Biological Macromolecules. 2024;274:133275 [Crossref]

24- Thanh T, Laowattanatham N, Ratanavaraporn J, Sereemaspun A, Yodmuang S. Hyaluronic acid crosslinked with alginate hydrogel: A versatile and biocompatible bioink platform for tissue engineering. European Polymer Journal. 2022;166:111027 [Crossref]

25- Malekzadeh A, Zahedi P, Abdouss M. Synthesis and performance evaluation of 5-fluorouracil-loaded zwitterionic poly(4-vinylpyridine) nanoparticles. New J Chem. 2022;46(18):8698 [Crossref]

26- Pacheco M, Lutz H, Armada J, Davies N, Gerzenshtein I, Cakley A, Spiess B, Stoppel W. Silk Fibroin Particles as Carriers in the Development of Hemoglobin‐Based Oxygen Carriers. Advanced NanoBiomed Research. 2023;3(9) [Crossref]

27- Hamza K, El-Shanshory A, Agwa M, Abo-Alkasem M, El-Fakharany E, Abdelsattar A, El-Bardan A, Kassem T, Mo X, Soliman H. Topically Applied Biopolymer-Based Tri-Layered Hierarchically Structured Nanofibrous Scaffold with a Self-Pumping Effect for Accelerated Full-Thickness Wound Healing in a Rat Model. Pharmaceutics. 2023;15(5):1518 [Crossref]

28- Guo Y, Karimi F, Fu Q, G. Qiao G, Zhang H. Reduced administration frequency for the treatment of fungal keratitis: a sustained natamycin release from a micellar solution. Expert Opinion on Drug Delivery. 2020;17(3):407 [Crossref]

29- Păun A, Popescu S, Ungureanu C, Trusca R, Pirvu C. Reduced TiO2 Nanotubes/Silk Fibroin/ZnO as a Promising Hybrid Antibacterial Coating. ChemPlusChem. 2024;89(3) [Crossref]

30- Pham D, Dey S, Katayama A. Activation of extracellular electron network in non-electroactive bacteria by Bombyx mori silk. International Journal of Biological Macromolecules. 2022;195:1 [Crossref]

31- D'Onofrio I, De Giorgio G, Sajapin R, Vurro D, Liboà A, Dembech E, Trevisi G, Botti M, Galstyan V, Tarabella G, D'Angelo P. Inhalable drug-loaded silk fibroin carriers for pulmonary drug delivery. RSC Adv. 2024;14(37):27288 [Crossref]

32- Mohammadi A, Eivazzadeh-Keihan R, Aliabadi H, Kashtiaray A, Cohan R, Bani M, Komijani S, Etminan A, salehpour N, Maleki A, Mahdavi M. Magnetic carboxymethyl cellulose-silk fibroin hydrogel: A ternary nanobiocomposite exhibiting excellent biological activity and in vitro hyperthermia of cancer therapy. Journal of Biotechnology. 2023;367:71 [Crossref]