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Adv Pharm Bull. 2019;9(4): 601-608. doi: 10.15171/apb.2019.069
PMID: 31857964        PMCID: PMC6912188

Research Article

Preparation and Characterization of Silk Fibroin Nanoparticles as a Potential Drug Delivery System for 5-Fluorouracil

Hamid Rahmani 1,2 ORCID, Ali Fattahi 3 * ORCID, Komail Sadrjavadi 1 * ORCID, Salar Khaledian 3 ORCID, Yalda Shokoohinia 1 ORCID

Cited by CrossRef: 25


1- Eivazzadeh-Keihan R, Mohammadi A, Aghamirza Moghim Aliabadi H, Kashtiaray A, Bani M, Karimi A, Maleki A, Mahdavi M. A novel ternary magnetic nanobiocomposite based on tragacanth-silk fibroin hydrogel for hyperthermia and biological properties. Sci Rep. 2024;14(1) [Crossref]
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12- Vafapour F, Bagheri F, Farokhi M. Development of pH-Sensitive Alendronate-Decorated Silk Fibroin/ Alginate Nanoparticles for Active Targeting of Doxorubicin to Bone Cancers. J Clust Sci. 2024; [Crossref]
13- Gagliardi A, Ambrosio N, Voci S, Salvatici M, Fresta M, Cosco D. Easy preparation, characterization and cytotoxic investigation of 5-Fluorouracil-loaded zein/sericin nanoblends. Journal of Molecular Liquids. 2022;366:120344 [Crossref]
14- Hudiță A, Radu I, Zaharia C, Ion A, Ginghină O, Gălățeanu B, Măruțescu L, Grama F, Tsatsakis A, Gurevich L, Costache M. Bio- and Hemo-Compatible Silk Fibroin PEGylated Nanocarriers for 5-Fluorouracil Chemotherapy in Colorectal Cancer: In Vitro Studies. Pharmaceutics. 2021;13(5):755 [Crossref]
15- Zhang S, Shah S, Basharat K, Qamar S, Raza A, Mohamed A, Bilal M, Iqbal H. Silk-based nano-hydrogels for futuristic biomedical applications. Journal of Drug Delivery Science and Technology. 2022;72:103385 [Crossref]
16- Ghalei S, Handa H. A review on antibacterial silk fibroin-based biomaterials: current state and prospects. Materials Today Chemistry. 2022;23:100673 [Crossref]
17- Safaiee R, Aminzadeh H, Sardarian A, Nasresfahani S, Sheikhi M. A high loading nanocarrier for the 5-fluorouracil anticancer drug based on chloromethylated graphene. Phys Chem Chem Phys. 2024;26(7):6410 [Crossref]
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19- Baci G, Baciu E, Cucu A, Muscă A, Giurgiu A, Moise A, Zăhan M, Dezmirean D. Sericultural By-Products: The Potential for Alternative Therapy in Cancer Drug Design. Molecules. 2023;28(2):850 [Crossref]
20- Rajendra P, Nidamanuri B, Balan A, Venkatachalam S, Jawahar N. A review on structure, preparation and applications of silk fibroin-based nano-drug delivery systems. J Nanopart Res. 2022;24(7) [Crossref]
21- Florczak A, Deptuch T, Kucharczyk K, Dams-Kozlowska H. Systemic and Local Silk-Based Drug Delivery Systems for Cancer Therapy. Cancers. 2021;13(21):5389 [Crossref]
22- Thanh T, Laowattanatham N, Ratanavaraporn J, Sereemaspun A, Yodmuang S. Hyaluronic acid crosslinked with alginate hydrogel: A versatile and biocompatible bioink platform for tissue engineering. European Polymer Journal. 2022;166:111027 [Crossref]
23- Malekzadeh A, Zahedi P, Abdouss M. Synthesis and performance evaluation of 5-fluorouracil-loaded zwitterionic poly(4-vinylpyridine) nanoparticles. New J Chem. 2022;46(18):8698 [Crossref]
24- Pacheco M, Lutz H, Armada J, Davies N, Gerzenshtein I, Cakley A, Spiess B, Stoppel W. Silk Fibroin Particles as Carriers in the Development of Hemoglobin‐Based Oxygen Carriers. Advanced NanoBiomed Research. 2023;3(9) [Crossref]
25- Hamza K, El-Shanshory A, Agwa M, Abo-Alkasem M, El-Fakharany E, Abdelsattar A, El-Bardan A, Kassem T, Mo X, Soliman H. Topically Applied Biopolymer-Based Tri-Layered Hierarchically Structured Nanofibrous Scaffold with a Self-Pumping Effect for Accelerated Full-Thickness Wound Healing in a Rat Model. Pharmaceutics. 2023;15(5):1518 [Crossref]
26- Guo Y, Karimi F, Fu Q, G. Qiao G, Zhang H. Reduced administration frequency for the treatment of fungal keratitis: a sustained natamycin release from a micellar solution. Expert Opinion on Drug Delivery. 2020;17(3):407 [Crossref]
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28- Pham D, Dey S, Katayama A. Activation of extracellular electron network in non-electroactive bacteria by Bombyx mori silk. International Journal of Biological Macromolecules. 2022;195:1 [Crossref]
29- Mohammadi A, Eivazzadeh-Keihan R, Aliabadi H, Kashtiaray A, Cohan R, Bani M, Komijani S, Etminan A, salehpour N, Maleki A, Mahdavi M. Magnetic carboxymethyl cellulose-silk fibroin hydrogel: A ternary nanobiocomposite exhibiting excellent biological activity and in vitro hyperthermia of cancer therapy. Journal of Biotechnology. 2023;367:71 [Crossref]