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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2020;10(1): 20-29. doi: 10.15171/apb.2020.003
PMID: 32002358        PMCID: PMC6983984

Research Article

Formulation and Evaluation of Eudragit RL-100 Nanoparticles Loaded In-Situ Forming Gel for Intranasal Delivery of Rivastigmine

Sara Salatin 1,2 ORCID, Jaleh Barar 1,3 * , Mohammad Barzegar-Jalali 3, Khosro Adibkia 3,4, Mitra Alami-Milani 3, Mitra Jelvehgari 3,4 * ORCID

Cited by CrossRef: 27

1- Nunes D, Loureiro J, Pereira M. Drug Delivery Systems as a Strategy to Improve the Efficacy of FDA-Approved Alzheimer’s Drugs. Pharmaceutics. 2022;14(11):2296 [Crossref]
2- Maheen S, Awan M, Abbas G, Shah S, Khan H, Khan I, Almehizia A, Khan M, Majeed A, Razzaq S, Younis H, Shafqat S. Design, statistical optimization, in vitro and biological characterization of Eudragit L100-gelatin based buccoadhesive bilayer patch for managing oral mucositis. International Journal of Biological Macromolecules. 2025;308:142070 [Crossref]
3- Bhanderi M, Shah J, Gorain B, Nair A, Jacob S, Asdaq S, Fattepur S, Alamri A, Alsanie W, Alhomrani M, Nagaraja S, Anwer M. Optimized Rivastigmine Nanoparticles Coated with Eudragit for Intranasal Application to Brain Delivery: Evaluation and Nasal Ciliotoxicity Studies. Materials. 2021;14(21):6291 [Crossref]
4- Farjami A, Salatin S, Jafari S, Mahmoudian M, Jelvehgari M. The Factors Determining the Skin Penetration and Cellular Uptake of Nanocarriers: New Hope for Clinical Development. CPD. 2021;27(42):4315 [Crossref]
5- Salatin S, Asadi R, Jelvehgari M. Development and Characterization of Sublingual Films for Enhanced Bioavailability of Selegiline Hydrochloride. Ther Deliv. 2021;12(2):159 [Crossref]
6- Shah D, Bhattacharya S, Gupta G, Hatware K, Jain A, Manthalkar L, Phatak N, Sreelaya P. d-α-tocopheryl polyethylene glycol 1000 succinate surface scaffold polysarcosine based polymeric nanoparticles of enzalutamide for the treatment of colorectal cancer: In vitro, in vivo characterizations. Heliyon. 2024;10(3):e25172 [Crossref]
7- Salatin S, Jelvehgari M. Desirability function approach for development of a thermosensitive and bioadhesive nanotransfersome–hydrogel hybrid system for enhanced skin bioavailability and antibacterial activity of cephalexin. Drug Development and Industrial Pharmacy. 2020;46(8):1318 [Crossref]
8- DATTA A, DAS A, GHOSH R. EUDRAGIT® RL100 MICROSPHERES AS DELAYED-RELEASE SYSTEM FOR IBUPROFEN: IN VITRO EVALUATION. Int J Pharm Pharm Sci. 2022;:6 [Crossref]
9- M, Unnithan D, Bano A, Chauhan A, Ali J, Khan M. Targeting Alzheimer’s disease pathology: influence of nano-based drug delivery systems loaded with a combination of herbal and synthetic drugs. Expert Opinion on Drug Delivery. 2025;22(8):1155 [Crossref]
10- Navarro-Ruíz E, Álvarez-Álvarez C, Peña M, Torrado-Salmerón C, Dahma Z, de la Torre-Iglesias P. Multiparticulate Systems of Meloxicam for Colonic Administration in Cancer or Autoimmune Diseases. Pharmaceutics. 2022;14(7):1504 [Crossref]
11- Zhang Y, Zhang J, Zhao Y, Zhou M, Xie X, Chen Y. Structure characterization and construction analysis of a calcium-vitamin D3 co-delivery aqueous solution system based on α-cyclodextrin/casein phosphopeptide. Food Chemistry. 2025;492:145548 [Crossref]
12- Salatin S, Lotfipour F, Jelvehgari M. Preparation and characterization of a novel thermosensitive and bioadhesive cephalexin nanohydrogel: a promising platform for topical antibacterial delivery. Expert Opinion on Drug Delivery. 2020;17(6):881 [Crossref]
13- Huang N, Huang W, Wang M, Shi J, Luo Y, Huang J. Biomaterials in Alzheimer's Disease: An Anti‐Neuroinflammatory Perspective. Adv Healthcare Materials. 2025;14(19) [Crossref]
14- Alami-Milani M, Salatin S, Rayeni F, Jelvehgari M. Preparation and In Vitro Evaluation of Thermosensitive and Mucoadhesive Hydrogels for Intranasal Delivery of Phenobarbital Sodium . Ther Deliv. 2021;12(6):461 [Crossref]
15- Raval H, Bhattacharya S. Exploring the Potentials of Hyaluronic Acid-coated Polymeric Nanoparticles in Enhanced Cancer Treatment by Precision Drug Delivery, Tackling Drug Resistance, and Reshaping the Tumour Micro Environment. CMC. 2025;32(20):3960 [Crossref]
16- Rathee J, Kumar K, Keluskar A, Kaushik D, Kumar S, Kanwar R, Patil M, Mehta S, Salunke D, Pawar S. Proficiency of pluronic based niosomes as an effective nano-carrier for the formulation of toll-like receptor-7/8 agonists. Journal of Drug Delivery Science and Technology. 2025;107:106764 [Crossref]
17- Reddy HV R, Bhattacharyya S. In vitro evaluation of mucoadhesive in situ nanogel of celecoxib for buccal delivery. Annales Pharmaceutiques Françaises. 2021;79(4):418 [Crossref]
18- Gao Y, Almalki W, Afzal O, Panda S, Kazmi I, Alrobaian M, Katouah H, Altamimi A, Al-Abbasi F, Alshehri S, Soni K, Ibrahim I, Rahman M, Beg S. Systematic development of lectin conjugated microspheres for nose-to-brain delivery of rivastigmine for the treatment of Alzheimer’s disease. Biomedicine & Pharmacotherapy. 2021;141:111829 [Crossref]
19- Tuntarawongsa S, Mahadlek J, Senarat S, Phaechamud T. Eudragit® RL in 2-pyrrolidone as antisolvent-based in-situ forming matrix. Materials Today: Proceedings. 2022;52:2534 [Crossref]
20- Singh B, Day C, Abdella S, Garg S. Alzheimer's disease current therapies, novel drug delivery systems and future directions for better disease management. Journal of Controlled Release. 2024;367:402 [Crossref]
21- Kumar Mohapatra P, Kumar B, Singh Patel P, Chandra Verma H, Sahoo S. Development and Evaluation of Trans Buccal Patches based on Natural and Synthetic Polymers Loaded with Rivastigmine using Solvent Casting Technique. RJPT. 2021;:5133 [Crossref]
22- Mohammed K, Rasslan F, Abd El‑Fattah M, Shawky S, Amin O, Eassa H. Treating Burn Infections With Topical Delivery of Positively Charged Norfloxacin-Loaded Lipid-Polymer Hybrid Nanoparticles. RADDF. 2025;19(2):142 [Crossref]
23- Majee S, Gupti S, Mishra T. Fabrication, Physicochemical and Pharmaceutical Characterization of Losartan Potassium–Loaded Buccal Films. Mal J Pharm. 2024;2(10):31 [Crossref]
24- Salatin S, Alami-Milani M, Jelvehgari M. Expert Design and Optimization of a Novel Buccoadhesive Blend Film Impregnated with Metformin Nanoparticles. Ther Deliv. 2020;11(9):573 [Crossref]
25- Pandya A, Vora L, Umeyor C, Surve D, Patel A, Biswas S, Patel K, Patravale V. Polymeric in situ forming depots for long-acting drug delivery systems. Advanced Drug Delivery Reviews. 2023;200:115003 [Crossref]
26- Farhoudi M, Sadigh-Eteghad S, Mahmoudi J, Farjami A, Mahmoudian M, Salatin S. The Therapeutic Benefits of Intravenously Administrated Nanoparticles in Stroke and Age-related Neurodegenerative Diseases. CPD. 2022;28(24):1985 [Crossref]
27- Salatin S, Tarzamani M, Farjami A, Jelvehgari M. Development and Characterization of a Novel Mucoadhesive sol-gel Suppository of Sumatriptan: design, optimization, In Vitro and Ex Vivo Evaluation for Rectal Drug Delivery . Ther Deliv. 2022;13(2):95 [Crossref]
28- Lotfipour F, Shahi S, Farjami A, Salatin S, Mahmoudian M, Dizaj S, Husain K. Safety and Toxicity Issues of Therapeutically Used Nanoparticles from the Oral Route. BioMed Research International. 2021;2021(1) [Crossref]
29- Mohapatra P, Srivastava R, Varshney K, Babu S. Formulation and Evaluation of Isradipine Nanosuspension and Exploring its Role as a Potential Anticancer Drug by Computational Approach. ACAMC. 2022;22(10):1984 [Crossref]
30- Sharma M, Gupta N. Mucoadhesive Cationic Bromelain Laden Nanocarriers Restore Patency of Airway Hyperresponsive Remodeling via Nasal Route. Advanced Therapeutics. 2023;6(6) [Crossref]
31- Avendaño-Godoy J, Miranda A, Mennickent S, Gómez-Gaete C. Intramuscularly Administered PLGA Microparticles for Sustained Release of Rivastigmine: In Vitro, In Vivo and Histological Evaluation. Journal of Pharmaceutical Sciences. 2023;112(12):3175 [Crossref]
32- Li A, Tyson J, Patel S, Patel M, Katakam S, Mao X, He W. Emerging Nanotechnology for Treatment of Alzheimer’s and Parkinson’s Disease. Front Bioeng Biotechnol. 2021;9 [Crossref]
33- Alami-Milani M, Salatin S, Nasiri E, Jelvehgari M. Preparation and Optimization of Fast Disintegrating Tablets of Isosorbide Dinitrate Using Lyophilization Method for Oral Drug Delivery. Ther Deliv. 2021;12(7):523 [Crossref]