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Adv Pharm Bull. 2019;9(4): 510-520. doi: 10.15171/apb.2019.061
PMID: 31857956        PMCID: PMC6912174

Review Article

Current Biochemical Applications and Future Prospects of Chlorotoxin in Cancer Diagnostics and Therapeutics

Sbonelo Khanyile 1 ORCID, Priscilla Masamba 1 ORCID, Babatunji Emmanuel Oyinloye 1,2 ORCID, Londiwe Simphiwe Mbatha 1, Abidemi Paul Kappo 1 * ORCID

Cited by CrossRef: 10


1- Wiranowska M. Advances in the use of chitosan and chlorotoxin- functionalized chitosan polymers in drug delivery and detection of glioma – A review. Carbohydrate Polymer Technologies and Applications. 2024;7:100427 [Crossref]
2- Chang C, Chen C. 5-aminolevulinic enhanced brain lesions mimic glioblastoma: A case report and literature review. 2024;103(1):e34518 [Crossref]
3- Molavinia S, Salehcheh M, Baradaran M, Karimi M, Pirmoradi G, Mohammadi E. The effects of chlorotoxin and its derivatives on glioma cells: a systematic review of in vitro studies . Toxin Reviews. 2024;43(2):255 [Crossref]
4- Boltman T, Sibuyi N, Ekpo O, Meyer M. Synthesis of chlorotoxin functionalized metallic nanoparticles and their in vitro evaluation of cytotoxic effects in nervous system cancer cell lines. Nano Ex. 2024;5(4):045002 [Crossref]
5- Yamada M, Miller D, Lowe M, Rowe C, Wood D, Soyer H, Byrnes-Blake K, Parrish-Novak J, Ishak L, Olson J, Brandt G, Griffin P, Spelman L, Prow T. A first-in-human study of BLZ-100 (tozuleristide) demonstrates tolerability and safety in skin cancer patients. Contemporary Clinical Trials Communications. 2021;23:100830 [Crossref]
6- Araújo E, Carneiro S, Neto D, Freire T, Costa V, Freire R, Fechine L, Clemente C, Denardin J, dos Santos J, Santos-Oliveira R, Rocha J, Fechine P. Advances in surface design and biomedical applications of magnetic nanoparticles. Advances in Colloid and Interface Science. 2024;328:103166 [Crossref]
7- Zhao L, Zhu J, Gong J, Song N, Wu S, Qiao W, Yang J, Zhu M, Zhao J. Polyethylenimine-based theranostic nanoplatform for glioma-targeting single-photon emission computed tomography imaging and anticancer drug delivery. J Nanobiotechnol. 2020;18(1) [Crossref]
8- Giribaldi J, Smith J, Schroeder C. Recent developments in animal venom peptide nanotherapeutics with improved selectivity for cancer cells. Biotechnology Advances. 2021;50:107769 [Crossref]
9- Montaño-Samaniego M, Bravo-Estupiñan D, Méndez-Guerrero O, Alarcón-Hernández E, Ibáñez-Hernández M. Strategies for Targeting Gene Therapy in Cancer Cells With Tumor-Specific Promoters. Front Oncol. 2020;10 [Crossref]
10- Boltman T, Meyer M, Ekpo O. Diagnostic and Therapeutic Approaches for Glioblastoma and Neuroblastoma Cancers Using Chlorotoxin Nanoparticles. Cancers. 2023;15(13):3388 [Crossref]
11- Vyawahare A, Ansari M, Kumar A, Ahmad A, Mishra R, Jori C, Nadeem A, Siddiqui N, Raza S, Khan R. Enzyme targeted delivery of sivelestat loaded nanomicelle inhibits arthritic severity in experimental arthritis. Life Sciences. 2023;334:122206 [Crossref]