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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2019;9(4): 685-689. doi: 10.15171/apb.2019.080
PMID: 31857975        PMCID: PMC6912173

Short Communication

10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest

Andrea Rasmussen 1 ORCID, Kaylee Murphy 2, David W. Hoskin 1,2,3 * ORCID

Cited by CrossRef: 18

1- Ediriweera M, Moon J, Nguyen Y, Cho S. 10-Gingerol Targets Lipid Rafts Associated PI3K/Akt Signaling in Radio-Resistant Triple Negative Breast Cancer Cells. Molecules. 2020;25(14):3164 [Crossref]
2- Salari Z, Khosravi A, Pourkhandani E, Molaakbari E, Salarkia E, Keyhani A, Sharifi I, Tavakkoli H, Sohbati S, Dabiri S, Ren G, Shafie’ei M. The inhibitory effect of 6-gingerol and cisplatin on ovarian cancer and antitumor activity: In silico, in vitro, and in vivo. Front Oncol. 2023;13 [Crossref]
3- Barboza J, Pereira F, Vasconcelos C, de Sousa Ribeiro M, Lopes A. Molecular mechanisms of action and chemosensitization of tumor cells in ovarian cancer by phytochemicals: A narrative review on pre‐clinical and clinical studies. Phytotherapy Research. 2023;37(6):2484 [Crossref]
4- Wala K, Szlasa W, Sauer N, Kasperkiewicz-Wasilewska P, Szewczyk A, Saczko J, Rembiałkowska N, Kulbacka J, Baczyńska D. Anticancer Efficacy of 6-Gingerol with Paclitaxel against Wild Type of Human Breast Adenocarcinoma. Molecules. 2022;27(9):2693 [Crossref]
5- Yücel Ç, Karatoprak G, Açıkara Ö, Akkol E, Barak T, Sobarzo-Sánchez E, Aschner M, Shirooie S. Immunomodulatory and anti-inflammatory therapeutic potential of gingerols and their nanoformulations. Front Pharmacol. 2022;13 [Crossref]
6- Liu M, Yang Y, Zhang M, Xue Y, Zheng B, Zhang Y, Liu Y, Chu X, Sun Z, Han X. Inhibition of human ether-à-go-go-related gene K+ currents expressed in HEK293 cells by three gingerol components from ginger. 2022;74(8):1133 [Crossref]
7- Deng B, Jiang X, Xu Y, Chen S, Cai M, Deng S, Ding W, Xu H, Zhang S, Tan Z, Chen R, Liu B, Zhang J. 10-Gingerol, a natural AMPK agonist, suppresses neointimal hyperplasia and inhibits vascular smooth muscle cell proliferation. Food Funct. 2022;13(6):3234 [Crossref]
8- Jhulki S, Pal A. Current Prospects of Phytochemical-Based Treatment for Ovarian Cancer: A Brief Review. Indian J Gynecol Oncolog. 2023;21(3) [Crossref]
9- Zhang X, Cai A, Gao Y, Zhang Y, Duan X, Men K. Treatment of Melanoma by Nano-conjugate-Delivered Wee1 siRNA. Mol Pharmaceutics. 2021;18(9):3387 [Crossref]
10- Zimmermann-Klemd A, Reinhardt J, Winker M, Gründemann C. Phytotherapy in Integrative Oncology—An Update of Promising Treatment Options. Molecules. 2022;27(10):3209 [Crossref]
11- Khan H, Arif Z. Biological evaluation of selected phytochemicals as a multi-targeted antitumor, antiproliferative and apoptotic agents in cancer. Pharmacological Research - Natural Products. 2024;5:100097 [Crossref]
12- Tian Y, Cheng J, Yang Y, Wang H, Fu Y, Li X, Wang W, Ma S, Xu X, Lu F, Feng P, Han S, Chen H, Hou H, Hu Q, Wu C. A 90-Day Subchronic Exposure to Heated Tobacco Product Aerosol Caused Differences in Intestinal Inflammation and Microbiome Dysregulation in Rats. 2025;27(3):438 [Crossref]
13- Saheed E. Anticancer potentials of bioactive compounds in some locally available spices in Nigeria. Discov Plants. 2024;1(1) [Crossref]
14- Verma P, Singh B, Sharma P, Tukra S, Aït-Kaddour A, Bhat Z. Mechanistic advances and therapeutic applications of Zingiber officinale Roscoe. Food Chemistry Advances. 2025;8:101060 [Crossref]
15- Dwi Oktaviani N, Maryati M. Potensi Sitotoksik Ekstrak Rizoma Jahe Merah (Zingiber officinale var. rubrum) terhadap Sel Kanker Payudara 4T1. JPS. 2025;:706 [Crossref]
16- Yahyazadeh R, Baradaran Rahimi V, Yahyazadeh A, Mohajeri S, Askari V. Promising effects of gingerol against toxins: A review article. BioFactors. 2021;47(6):885 [Crossref]
17- Guo J, Li Y, Yuan Y, Li X, Li X, Jiang X, Bai W, Jiao R. Cholesterol-lowering activity of 10-gingerol in HepG2 cells is associated with enhancing LDL cholesterol uptake, cholesterol efflux and bile acid excretion. Journal of Functional Foods. 2022;95:105174 [Crossref]