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Adv Pharm Bull. 2020;10(3): 359-369. doi: 10.34172/apb.2020.044
PMID: 32665894        PMCID: PMC7335980

Review Article

A Review on Solid Dispersion and Carriers Used Therein for Solubility Enhancement of Poorly Water Soluble Drugs

Avinash Ramrao Tekade 1 * ORCID, Jyoti Narayan Yadav 1

Cited by CrossRef: 63


1- Kim P, Lee I, Kim J, Mswahili M, Jeong Y, Yoon W, Yun H, Lee M, Choi G. A study to discover novel pharmaceutical cocrystals of pelubiprofen with a machine learning approach compared. CrystEngComm. 2022;24(21):3938 [Crossref]
2- Bedhiafi T, Idoudi S, Fernandes Q, Al-Zaidan L, Uddin S, Dermime S, Billa N, Merhi M. Nano-vitamin C: A promising candidate for therapeutic applications. Biomedicine & Pharmacotherapy. 2023;158:114093 [Crossref]
3- Kryuk T, Popyrina T, Romanenko N, Ivanov P, Svishcheva N, Akopova T, Khavpachev M. Preparation and Study of Solid Dispersions of Acyclovir with Starch and Carboxymethylcellulose. Polym Sci Ser C. 2024;66(1):39 [Crossref]
4- Patel K, Patel J, Shah S. Development of Delayed Release Oral Formulation Comprising Esomeprazole Spray Dried Dispersion Utilizing Design of Experiment As An Optimization Strategy. AAPS PharmSciTech. 2023;24(7) [Crossref]
5- Taldaev A, Pankov D, Terekhov R, Zhevlakova A, Selivanova I. Modification of the Physicochemical Properties of Active Pharmaceutical Ingredients via Lyophilization. Pharmaceutics. 2023;15(11):2607 [Crossref]
6- Danilova A, Gusev K, Maimistov D, Flisyuk E. Hot Melt Extrusion Technology as a Modern Strategy for Improving the Bioavailability of Flavonoids. Pharm Chem J. 2024;58(2):297 [Crossref]
7- ALATAS F, RATIH , SUTARNA T, FAUZI M. THE BINARY AND TERNARY AMORPHOUS SYSTEMS OF CANDESARTAN CILEXETIL PREPARATION TO IMPROVE ITS SOLUBILITY. Int J App Pharm. 2024;:368 [Crossref]
8- Patel K, Shah S, Patel J. Solid dispersion technology as a formulation strategy for the fabrication of modified release dosage forms: A comprehensive review. DARU J Pharm Sci. 2022;30(1):165 [Crossref]
9- Elshaer M, Osman S, Mohammed A, Zayed G. Co-crystallization of Hesperidin with different co-formers to enhance solubility, antioxidant and anti-inflammatory activities. Pharmaceutical Development and Technology. 2024;29(7):691 [Crossref]
10- SAHA S, JOSHI A, SINGH R, DUBEY K. ENHANCED SOLUBILITY AND DISSOLUTION BY SURFACE-MODIFIED SOLID DISPERSION OF ALECTINIB HYDROCHLORIDE. Int J App Pharm. 2023;:257 [Crossref]
11- Mishra A, Chaturvedi P, Mishra P, Sudheesh M. Comparative Evaluation of Amorphous Polymers in Solubility and Bioavailability Enhancement of Famotidine Through Solid Dispersion. EJPPS. 2021; [Crossref]
12- Роїк О, Голодюк О. Technology for obtaining a highly soluble dispersion of atorvastatin to increase bioavailability. Farm Zh. 2024;(4):52 [Crossref]
13- Wang Q, Yang X, Gu X, Wei F, Cao W, Zheng L, Li Y, Ma T, Wu C, Wang Q. Celecoxib nanocrystal-loaded dissolving microneedles with highly efficient for osteoarthritis treatment. International Journal of Pharmaceutics. 2022;625:122108 [Crossref]
14- Wang Y, Xu S, Xiao Z, Jiang Y, Jiang Q, Li J, He W. Stiripentol Enteric Solid Dispersion-Loaded Effervescent Tablets: Enhanced Dissolution, Stability, and Absorption. AAPS PharmSciTech. 2022;23(5) [Crossref]
15- Modi D, Jonnalagadda S, Campbell G, Dalwadi G. Enhancing Oil Solubility of BCS Class II Drug Phenytoin Through Hydrophobic Ion Pairing to Enable High Drug Load in Injectable Nanoemulsion to Prevent Precipitation at Physiological pH With a Potential to Prevent Phlebitis. Journal of Pharmaceutical Sciences. 2023;112(9):2427 [Crossref]
16- Крюк Т, Попырина Т, Романенко Н, Иванов П, Свищева Н, Акопова Т, Хавпачев М. Получение и исследование твердых дисперсий ацикловира с крахмалом и карбоксиметилцеллюлозой. Polymer Science, Series A. 2024;66(2):114 [Crossref]
17- Dahma Z, Torrado-Salmerón C, Álvarez-Álvarez C, Guarnizo-Herrero V, Martínez-Alonso B, Torrado G, Torrado-Santiago S, de la Torre-Iglesias P. Topical Meloxicam Hydroxypropyl Guar Hydrogels Based on Low-Substituted Hydroxypropyl Cellulose Solid Dispersions. Gels. 2024;10(3):207 [Crossref]
18- Jurel P, Garg A. Recent advances in solid dispersion technique for enhancing biopharmaceutical properties of lumefantrine. 2023;22(1):1 [Crossref]
19- Mohapatra D, Agrawal A, Sahu A. Exploring the potential of solid dispersion for improving solubility, dissolution & bioavailability of herbal extracts, enriched fractions, and bioactives. Journal of Microencapsulation. 2021;38(7-8):594 [Crossref]
20- MADHAVI N, SUDHAKAR B, SRAVANI U. DEVELOPMENT AND EVALUATION OF ITRACONAZOLE SOLID DISPERSION GEL CUTANEOUS DELIVERY. Int J App Pharm. 2023;:334 [Crossref]
21- Jiang H, Zhang M, Lin X, Zheng X, Qi H, Chen J, Zeng X, Bai W, Xiao G. Biological Activities and Solubilization Methodologies of Naringin. Foods. 2023;12(12):2327 [Crossref]
22- Swati N, Atish V, Prakash J. Review on Laboratory Scale Solid Dispersion Techniques. AJPS. 2023;:167 [Crossref]
23- Chitprasert P, Dumrongchai T, Rodklongtan A. Effect of in vitro dynamic gastrointestinal digestion on antioxidant activity and bioaccessibility of vitexin nanoencapsulated in vaterite calcium carbonate. LWT. 2023;173:114366 [Crossref]
24- Mujtaba M, Kaleem M, Chaware R, Ingole A, Asiri Y, Hassan M, Sabale V, Sabale P, Anwer M, Mahmood D, Aldawsari M. Development and Optimization of Proniosomal Formulation of Irbesartan Using a Box–Behnken Design to Enhance Oral Bioavailability: Physicochemical Characterization and In Vivo Assessment. ACS Omega. 2024;9(14):16346 [Crossref]
25- Gupta K, Dakhole M, Jinnawar K, Umekar M. Strategies for improving hydrophobic drugs solubility and bioavailability. IJPCA. 2023;10(3):164 [Crossref]
26- Zheng H, Xie X, Ling H, You X, Liang S, Lin R, Qiu R, Hou H. Transdermal drug delivery via microneedles for musculoskeletal systems. J Mater Chem B. 2023;11(35):8327 [Crossref]
27- Shan X, Moghul M, Williams A, Khutoryanskiy V. Mutual Effects of Hydrogen Bonding and Polymer Hydrophobicity on Ibuprofen Crystal Inhibition in Solid Dispersions with Poly(N-vinyl pyrrolidone) and Poly(2-oxazolines). Pharmaceutics. 2021;13(5):659 [Crossref]
28- Rana H, Panchal P, Dholakia M, Thakkar V. Exploration, Development and Optimization of Eco-friendly Novel Dosage Form – Pastilles. CDTH. 2023;18(2):117 [Crossref]
29- Mahfud M, Syahirah N, Akram M, Mahfufah U, Saputra M, Elim D, Andi M, Sultan N, Himawan A, Domínguez-Robles J, Pamornpathomkul B, Mir M, Permana A. Solid Dispersion Incorporated into Dissolving Microneedles for Improved Antifungal Activity of Amphotericin B: In Vivo Study in a Fungal Keratitis Model. Mol Pharmaceutics. 2023;20(12):6246 [Crossref]
30- Gahtani R, Hani U, Fatima F, Nadeem T, Osmani R. Thermal optimization of ivermectin in supercritical carbon dioxide and ethanol to produce nano medicine. Case Studies in Thermal Engineering. 2024;61:105098 [Crossref]
31- Borcan F, Vlase T, Vlase G, Popescu R, Soica C. The Influence of an Isocyanate Structure on a Polyurethane Delivery System for 2′-Deoxycytidine-5′-monophosphate. JFB. 2023;14(10):526 [Crossref]
32- Inam S, Irfan M, Lali N, Khalid Syed H, Asghar S, Khan I, Khan S, Iqbal M, Zaheer I, Khames A, Abou-Taleb H, Abourehab M. Development and Characterization of Eudragit® EPO-Based Solid Dispersion of Rosuvastatin Calcium to Foresee the Impact on Solubility, Dissolution and Antihyperlipidemic Activity. Pharmaceuticals. 2022;15(4):492 [Crossref]
33- Bhujbal S, Mitra B, Jain U, Gong Y, Agrawal A, Karki S, Taylor L, Kumar S, (Tony) Zhou Q. Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies. Acta Pharmaceutica Sinica B. 2021;11(8):2505 [Crossref]
34- Racz L, Racz C, Pop L, Tomoaia G, Mocanu A, Barbu I, Sárközi M, Roman I, Avram A, Tomoaia-Cotisel M, Toma V. Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin. Molecules. 2022;27(20):6854 [Crossref]
35- Patel K, Kevlani V, Shah S. A novel Posaconazole oral formulation using spray dried solid dispersion technology: in-vitro and in-vivo study. Drug Deliv and Transl Res. 2024;14(5):1253 [Crossref]
36- SARKAR P, BISWAS MAJEE S. FORMULATION DEVELOPMENT AND IN VITRO CHARACTERIZATION OF TERNARY HYDROTROPIC SOLID DISPERSIONS OF ACECLOFENAC. Asian J Pharm Clin Res. 2022;:174 [Crossref]
37- Saha S, Joshi A, Singh R, Jana S, Dubey K. An investigation into solubility and dissolution improvement of alectinib hydrochloride as a third-generation amorphous solid dispersion. Journal of Drug Delivery Science and Technology. 2023;81:104259 [Crossref]
38- Sokač K, Priselec P, Barač J, Bafti A, Taradi F, Žižek K. Investigating the effect of polyvinylpyrrolidone matrix on surface characteristics and dissolution rate of anticancer drug dasatinib. J of Applied Polymer Sci. 2024;141(27) [Crossref]
39- Suvarna V, Singh V, Sharma D, Murahari M. Experimental and computational insight of the supramolecular complexes of Irbesartan with β-cyclodextrin based nanosponges. Journal of Drug Delivery Science and Technology. 2021;63:102494 [Crossref]
40- Abbaspour M, Faeznia F, Zanjanian P, Ruzbehi M, Shourgashti K, Ziaee A, Sardou H, Nokhodchi A. Preparation and Evaluation of Berberine-Excipient Complexes in Enhancing the Dissolution Rate of Berberine Incorporated into Pellet Formulations. AAPS PharmSciTech. 2024;25(6) [Crossref]
41- Raparla S, Lampa C, Li X, Jasti B. An empirical predictive model for determining the aqueous solubility of BCS class IV drugs in amorphous solid dispersions. Drug Development and Industrial Pharmacy. 2024;50(3):236 [Crossref]
42- Bhalani D, Kakkad H, Modh J, Ray D, Aswal V, Pillai S. Molecular insights into the aggregation and solubilizing behavior of biocompatible amphiphiles Gelucire® 48/16 and Tetronics® 1304 in aqueous media. RSC Adv. 2023;13(41):28590 [Crossref]
43- Nguyen T, Park J. Exploring Fenofibrate Formulations for the Treatment of Lipid Disorders: Past, Present, and Future. Cardiometab Syndr J. 2022;2(2):77 [Crossref]
44- Kubat K, Krupa A, Brniak W, Węgrzyn A, Majda D, Bogdał A, Harańczyk H. Data regarding particle size distribution, thermal properties and gaseous phase hydration of co-milled solid dispersions composed of tadalafil and Soluplus. Data in Brief. 2022;43:108451 [Crossref]
45- Ishimoto K, Nakamura Y, Otani S, Miki S, Maeda S, Iwamoto T, Konishi Y, Ago Y, Nakagawa S. Examination of dissolution ratio of β-carotene in water for practical application of β-carotene amorphous solid dispersion. J Food Sci Technol. 2022;59(1):114 [Crossref]
46- Rao M, Sapate S, Sonawane A. Pharmacotechnical Evaluation by SeDeM Expert System to Develop Orodispersible Tablets. AAPS PharmSciTech. 2022;23(5) [Crossref]
47- Alam M, Khandale N, Birla D, Bashir B, Vishwas S, Kulkarni M, Rajput R, Pandey N, Loebenberg R, Davies N, Gupta G, Dureja H, Kumbhar P, Disouza J, Kumar P, Dua K, Singh S. Formulation and optimization of xanthohumol loaded solid dispersion for effective treatment of Parkinson's disease in rats: In vitro and in vivo assessment. Journal of Drug Delivery Science and Technology. 2024;102:106385 [Crossref]
48- Shahiwala A. Studies in Solid Solution Formation between Acetaminophen and Povidone and Mouth-dissolving Strip Formulation. CPD. 2024;30(15):1200 [Crossref]
49- Rao M, Sonawane A, Sapate S, Mehta C, Nayak U. Molecular modeling and in vitro studies to assess solubility enhancement of nevirapine by solid dispersion technique. Journal of Molecular Structure. 2023;1273:134373 [Crossref]
50- Czajkowska-Kośnik A, Misztalewska-Turkowicz I, Wilczewska A, Basa A, Winnicka K. Solid Dispersions Obtained by Ball Milling as Delivery Platform of Etodolac, a Model Poorly Soluble Drug. Materials. 2024;17(16):3923 [Crossref]
51- AGUSTINA R, SETYANINGSIH D. SOLID DISPERSION AS A POTENTIAL APPROACH TO IMPROVE DISSOLUTION AND BIOAVAILABILITY OF CURCUMIN FROM TURMERIC (CURCUMA LONGA L.). Int J App Pharm. 2023;:37 [Crossref]
52- Baek K, Woo M, Choi Y, Kang M, Kim J, Choi H, Jin S. Engineering sodium alginate microparticles with different crystallinities for niclosamide repositioning and solubilization to improve solubility and oral bioavailability in rats. International Journal of Biological Macromolecules. 2024;283:137471 [Crossref]
53- Khan K, Minhas M, Badshah S, Suhail M, Ahmad A, Ijaz S. Overview of nanoparticulate strategies for solubility enhancement of poorly soluble drugs. Life Sciences. 2022;291:120301 [Crossref]
54- Deshkar S, Yeole P, Mahore J, Shinde A, Giram P. Polyelectrolyte-Complex-Based Hydrogel Inserts for Vaginal Delivery of Posaconazole and Probiotics. Gels. 2023;9(11):851 [Crossref]
55- Alwossabi A, Elamin E, Ahmed E, Abdelrahman M. Solubility enhancement of some poorly soluble drugs by solid dispersion using Ziziphus spina-christi gum polymer. Saudi Pharmaceutical Journal. 2022;30(6):711 [Crossref]
56- Rojas A, Sajadian S, Razmimanesh F, Aguila G, Esfandiari N, Jouyban A. Solubility of oxazepam in supercritical carbon dioxide: Experimental and modeling. Fluid Phase Equilibria. 2024;585:114165 [Crossref]
57- Raut S, Hajare A, Chougale R, Kamble S, Patil K. Formulation, Development, and Evaluation of Bosentan Monohydrate Spray Dried- Solid Dispersion Tablets for Improved Dissolution Profile. Jordan j pharm sci. 2023;16(4):714 [Crossref]
58- Himawan A, Djide N, Mardikasari S, Utami R, Arjuna A, Donnelly R, Permana A. A novel in vitro approach to investigate the effect of food intake on release profile of valsartan in solid dispersion-floating gel in-situ delivery system. European Journal of Pharmaceutical Sciences. 2022;168:106057 [Crossref]
59- Keleshovska B, Dimovska N, Smileva A, Dimova D. Improving the dissolution rate of Nebivolol hydrochloride by using nonionic surfactant and polymer combination. Maced Pharm Bull. 2022;68(03):279 [Crossref]
60- Block M, Sieger P, Truenkle C, Saal C, Simon R, Truebenbach I. Miniaturized screening and performance prediction of tailored subcutaneous extended-release formulations for preclinical in vivo studies. European Journal of Pharmaceutical Sciences. 2024;196:106733 [Crossref]
61- Poka M, Milne M, Wessels A, Aucamp M. Sugars and Polyols of Natural Origin as Carriers for Solubility and Dissolution Enhancement. Pharmaceutics. 2023;15(11):2557 [Crossref]
62- Fanda A, Jadhav A, Naruka P, Rana D, Benival D. Systematic Development of Hot Melt Extrusion-Based Amorphous Solid Dispersion: Integrating Quality by Design and In Silico Modeling. J Pharm Innov. 2024;19(3) [Crossref]
63- Singh D, Kaur P, Attri S, Singh S, Sharma P, Mohana P, Kaur K, Kaur H, Singh G, Rashid F, Singh D, Kumar A, Rajput A, Bedi N, Singh B, Buttar H, Arora S. Recent Advances in the Local Drug Delivery Systems for Improvement of Anticancer Therapy. CDD. 2022;19(5):560 [Crossref]
64- Alkathiri F, Bukhari S, Imam S, Alshehri S, Mahdi W. Formulation of silymarin binary and ternary solid dispersions: Characterization, simulation study and cell viability assessment against lung cancer cell line. Heliyon. 2024;10(1):e23221 [Crossref]
65- Paul S, Asha K, Alam I, Ali M, Al-Mamun M, Rahman M. Physicochemical reports of gliclazide-carplex solid dispersions and tablets prepared with directly compressible co-processed excipients. Heliyon. 2023;9(12):e22899 [Crossref]
66- Li Z, Jia R, Cai X, Luo D, Chen C, Zhao M. Characterizations of food-derived ellagic acid-Undaria pinnatifida polysaccharides solid dispersion and its benefits on solubility, dispersity and biotransformation of ellagic acid. Food Chemistry. 2023;413:135530 [Crossref]
67- Dain I, Zolotov S, Demina N, Zolotova A, Buzanov G, Retivov V, Ponomaryov Y. Complex dispersions of poloxamers and mesoporous carriers with ibrutinib. OpenNano. 2022;8:100073 [Crossref]
68- Joshi P, Rao G, Chatterjee B. Scope and Application of Hot Melt Extrusion in the Development of Controlled and Sustained Release Drug Delivery Systems. CPD. 2024;30(32):2513 [Crossref]