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Adv Pharm Bull. 2020;10(1): 130-134. doi: 10.15171/apb.2020.017
PMID: 32002372        PMCID: PMC6983996

Research Article

Restoration of miR-193a-5p and miR-146 a-5p Expression Induces G1 Arrest in Colorectal Cancer through Targeting of MDM2/p53

Saeed Noorolyai 1 ORCID, Elham Baghbani 1,2 ORCID, Leili Aghebati Maleki 1 ORCID, Amir Baghbanzadeh Kojabad 1, Dariush Shanehbansdi 1, Vahid Khaze Shahgoli 1, Ahad Mokhtarzadeh 1 ORCID, Behzad Baradaran 1 * ORCID

Cited by CrossRef: 16


1- Lai C, Xie C, Raufman J, Xie G. Targeting Post-Translational Regulation of p53 in Colorectal Cancer by Exploiting Vulnerabilities in the p53-MDM2 Axis. Cancers. 2022;14(1):219 [Crossref]
2- Liu Q, Wang S, Pei G, Yang Y, Min X, Huang Y, Liu J. Impact Analysis of miR-1253 on Lung Cancer Progression Through Targeted Regulation of ANXA3. CMAR. 2021;Volume 13:1767 [Crossref]
3- Azar M, Aghazadeh H, Mohammed H, Sara M, Hosseini A, Shomali N, Tamjidifar R, Tarzi S, Mansouri M, Sarand S, Marofi F, Akbari M, Xu H, Shotorbani S. miR-193a-5p as a promising therapeutic candidate in colorectal cancer by reducing 5-FU and Oxaliplatin chemoresistance by targeting CXCR4. International Immunopharmacology. 2021;92:107355 [Crossref]
4- Park W, Lee H, Sim D, Im E, Park J, Ahn C, Shim B, Kim S. miR193a-5p Mediated ZNF746 and c-Myc Signaling Axis Is Critically Involved in Morusin Induced Apoptosis in Colorectal Cancer Cells. Cells. 2021;10(8):2065 [Crossref]
5- Tomicic M, Dawood M, Efferth T. Epigenetic Alterations Upstream and Downstream of p53 Signaling in Colorectal Carcinoma. Cancers. 2021;13(16):4072 [Crossref]
6- Shan Y, Kong W, Zhu A, Zhang J, Ying R, Zhu W. Increased levels of miR‑372 correlate with disease progression in patients with hyperlipidemic acute pancreatitis. Exp Ther Med. 2020; [Crossref]
7- Ghafouri-Fard S, Abak A, Shoorei H, Mohaqiq M, Majidpoor J, Sayad A, Taheri M. Regulatory role of microRNAs on PTEN signaling. Biomedicine & Pharmacotherapy. 2021;133:110986 [Crossref]
8- Saharkhiz M, Tavakoli T, Fakharian T, Soltaninejad E, Naseri M. The relationship analysis of microRNA-146a rs2910164 polymorphism with risk of colorectal cancer in province of South-Khorasan, Iran. Gene Reports. 2020;21:100953 [Crossref]
9- Mirzaei S, Zarrabi A, Hashemi F, Zabolian A, Saleki H, Ranjbar A, Seyed Saleh S, Bagherian M, Sharifzadeh S, Hushmandi K, Liskova A, Kubatka P, Makvandi P, Tergaonkar V, Kumar A, Ashrafizadeh M, Sethi G. Regulation of Nuclear Factor-KappaB (NF-κB) signaling pathway by non-coding RNAs in cancer: Inhibiting or promoting carcinogenesis?. Cancer Letters. 2021;509:63 [Crossref]
10- Ye S, Yu C, Zhang G, Shi F, Chen Y, Yang J, Wu W, Zhou Y. Downregulation of microRNA‑126 is inversely correlated with insulin receptor substrate‑1 protein expression in colorectal cancer and is associated with advanced stages of disease. Oncol Lett. 2020;20(3):2411 [Crossref]
11- Ghafouri-Fard S, Shoorei H, Anamag F, Taheri M. The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells. Front Oncol. 2020;10 [Crossref]
12- Jiang P, Liang B, Zhang Z, Fan B, Zeng L, Zhou Z, Mao Z, Lin Q, Yao W, Shen Q. MicroRNA-146a-5p induces cell cycle arrest and enhances apoptosis in gastric cancer via targeting CDC14A. Front Cell Dev Biol. 2023;11 [Crossref]
13- Liu W, Li W, Zhang Y, Zhang M. Regulatory Effect of miR497-5p–CCNE1 Axis in Triple-Negative Breast Cancer Cells and Its Predictive Value for Early Diagnosis. CMAR. 2021;Volume 13:439 [Crossref]
14- Zhang L, Zhu D, Jiang J, Min Z, Fa Z. The ubiquitin E3 ligase MDM2 induces chemoresistance in colorectal cancer by degradation of ING3. 2023;44(7):562 [Crossref]
15- Valiulienė G, Zentelytė A, Beržanskytė E, Navakauskienė R. Effect of 3D Spheroid Culturing on NF-κB Signaling Pathway and Neurogenic Potential in Human Amniotic Fluid Stem Cells. IJMS. 2023;24(4):3584 [Crossref]
16- Yu D, Wei W, Hefeng Y, Weihao L, Qianqian Q, Song L. Upregulated ox40l Can Be Inhibited by miR-146a-5p in Condylar Chondrocytes Induced by IL-1β and TNF-α: A Possible Regulatory Mechanism in Osteoarthritis. Int Arch Allergy Immunol. 2021;182(5):408 [Crossref]