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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2021;11(1): 104-110. doi: 10.34172/apb.2021.011
PMID: 33747857        PMCID: PMC7961223

Research Article

Preparation and Safety Evaluation of Topical Simvastatin Loaded NLCs for Vitiligo

Sahar Yazdani Ashtiani 1 ORCID, Saman Ahmad Nasrollahi 1 * ORCID, Atefeh Naeimifar 2 ORCID, Aubid Nassiri Kashani 1, Aniseh Samadi 1 ORCID, Somayeh Yadangi 1, Ehsan Aboutaleb 3, Poorya Abdolmaleki 1, Rassoul Dinarvand 2 ORCID, Alireza Firooz 1 ORCID

Cited by CrossRef: 10

1- Gul M, Shah F, Sahar N, Malik I, Din F, Khan S, Aman W, Choi H, Lim C, Noh H, Noh J, Zeb A, Kim J. Formulation optimization, in vitro and in vivo evaluation of agomelatine-loaded nanostructured lipid carriers for augmented antidepressant effects. Colloids and Surfaces B: Biointerfaces. 2022;216:112537 [Crossref]
2- Bhange M, Kothawade S, Telange D, Padwal V. Emerging therapies and innovations in vitiligo management: a comprehensive review. Journal of Immunoassay and Immunochemistry. 2025;46(1):1 [Crossref]
3- Wang J, Zhang C, Wu H, Li G. recent advances in the pathogenesis of vitiligo and the application of novel drug delivery systems in its treatment. International Journal of Pharmaceutics: X. 2025;:100397 [Crossref]
4- Wollina U. Therapeutische Optionen bei Vitiligo. ästhet dermatol kosmetol. 2021;13(5):32 [Crossref]
5- Mousavi-Simakani S, Azadi A, Tanideh N, Omidifar N, Ghasemiyeh P, Mohammadi-Samani S. Simvastatin-Loaded Nanostructured Lipid Carriers as Topical Drug Delivery System for Wound Healing Purposes: Preparation, Characterization, and In Vivo Histopathological Studies. Adv Pharm Bull. 2023;13(4):761 [Crossref]
6- Nagendra Yadav B, Shah S, Alpesh Kumar Bhalani S, Rangwala A. Budding trends in nanofibers for topical delivery of therapeutics for the treatment of vitiligo. Journal of Biomaterials Science, Polymer Edition. 2025;:1 [Crossref]
7- Paul P, Veerabomma H, Gupta U, Atram D, Singh P, Mehra N, Godugu C, Baldi A, Madan J. Implication of colloidal therapeutics in the treatment of vitiligo: Portray of signaling cascade, current drug-targets and preclinical and clinical evidences. Journal of Drug Delivery Science and Technology. 2024;96:105666 [Crossref]
8- Alatawi H, Alhwiti S, Alsharif K, Albalawi S, Abusaleh S, Sror G, Qushawy M. Nanostructured Lipid Carriers (NLCs) as Effective Drug Delivery Systems: Methods of Preparation and their Therapeutic Applications. NANOTEC. 2024;18(2):179 [Crossref]
9- Yari E, Sari S, Kelidari H, Asare-Addo K, Nokhodchi A. Effect of Rosa damascena Essential Oil Loaded in Nanostructured Lipid Carriers on the Proliferation of Human Breast Cancer Cell Line MDA-MB-231 in Comparison with Cisplatin. J Pharm Innov. 2024;19(1) [Crossref]
10- Karami F, Saber-Samandari S. Synthesis and characterization of a novel hydrogel based on carboxymethyl chitosan/sodium alginate with the ability to release simvastatin for chronic wound healing. Biomed Mater. 2023;18(2):025001 [Crossref]
11- Javed S, Mangla B, Almoshari Y, Sultan M, Ahsan W. Nanostructured lipid carrier system: A compendium of their formulation development approaches, optimization strategies by quality by design, and recent applications in drug delivery. 2022;11(1):1744 [Crossref]
12- Wu H, Niu C, Aisa H. Research Progress in Small Molecules as Anti-vitiligo Agents. CMC. 2024;31(8):995 [Crossref]
13- Wollina U. Therapeutische Optionen bei Vitiligo. CME. 2021;18(12):59 [Crossref]