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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2020;10(4): 524-541. doi: 10.34172/apb.2020.064
PMID: 33072532        PMCID: PMC7539309

Review Article

Lipid Drug Carriers for Cancer Therapeutics: An Insight into Lymphatic Targeting, P-gp, CYP3A4 Modulation and Bioavailability Enhancement

Shashank Chaturvedi 1 * ORCID, Anurag Verma 2 ORCID, Vikas Anand Saharan 3 ORCID

Cited by CrossRef: 19

1- Yerram S, Joga R, Shende P, Varpe P, Bellapu K, Kumar S. Prominence of Bioresponsive DNA Nanococoons in Tackling Post-Surgery Cancer Recurrence. Pharm Pat Anal. 2023;12(5):219 [Crossref]
2- Wei D, Yang H, Zhang Y, Zhang X, Wang J, Wu X, Chang J. Nano-traditional Chinese medicine: a promising strategy and its recent advances. J Mater Chem B. 2022;10(16):2973 [Crossref]
3- Harisa G, Sherif A, Alanazi F, Ali E, Omran G, Nasr F, Attia S, Alqahtani A. TPGS decorated NLC shift gefitinib from portal absorption into lymphatic delivery: Intracellular trafficking, biodistribution and bioavailability studies. Colloids and Surfaces B: Biointerfaces. 2023;223:113148 [Crossref]
4- Chaturvedi S, Sharma R. Novel Delivery Systems of Raloxifene Hydrochloride for Improved Bioavailability and Therapeutic Efficacy: A Review. DDL. 2025;15(1):15 [Crossref]
5- Hervieu L, Groo A, Bellien J, Guerrot D, Malzert-Fréon A. Glucuronidation of orally administered drugs and the value of nanocarriers in strategies for its overcome. Pharmacology & Therapeutics. 2025;266:108773 [Crossref]
6- Sherif A, Harisa G, Shahba A, Alanazi F, Qamar W. Optimization of Gefitinib-Loaded Nanostructured Lipid Carrier as a Biomedical Tool in the Treatment of Metastatic Lung Cancer. Molecules. 2023;28(1):448 [Crossref]
7- MISHRA R, KULKARNI S, AHER A. ONE POT DEVELOPMENT OF LIPID-BASED QUERCETIN SPHERICAL AGGLOMERATES FOR BIOAVAILABILITY ENHANCEMENT: IN VITRO AND IN VIVO ASSESSMENTS. Int J App Pharm. 2023;:168 [Crossref]
8- Qiu C, Zhang J, Wu B, Xu C, Pang H, Tu Q, Lu Y, Guo Q, Xia F, Wang J. Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines. J Nanobiotechnol. 2023;21(1) [Crossref]
9- Chaturvedi S, Garg A, Verma A. Nano lipid based carriers for lymphatic voyage of anti-cancer drugs: An insight into the in-vitro, ex-vivo, in-situ and in-vivo study models. Journal of Drug Delivery Science and Technology. 2020;59:101899 [Crossref]
10- Handa M, Beg S, Shukla R, Barkat M, Choudhry H, Singh K. Recent advances in lipid-engineered multifunctional nanophytomedicines for cancer targeting. Journal of Controlled Release. 2021;340:48 [Crossref]
11- Sherif A, Harisa G, Alanazi F. The Chimera of TPGS and Nanoscale Lipid Carriers as Lymphatic Drug Delivery Vehicles to Fight Metastatic Cancers. CDD. 2024;21(4):525 [Crossref]
12- Knaggs K, Sun Y, Walz B, Pang J, Khan O. The role of excipients in lipid nanoparticle metabolism: implications for enhanced therapeutic effect. Therapeutic Delivery. 2025;:1 [Crossref]
13- Yoon S, Kim H. First-Line Combination Treatment with Low-Dose Bipolar Drugs for ABCB1-Overexpressing Drug-Resistant Cancer Populations. IJMS. 2023;24(9):8389 [Crossref]
14- Rehman M, Tahir N, Sohail M, Qadri M, Duarte S, Brandão P, Esteves T, Javed I, Fonte P. Lipid-Based Nanoformulations for Drug Delivery: An Ongoing Perspective. Pharmaceutics. 2024;16(11):1376 [Crossref]
15- Chaturvedi S, Rastogi V, Kumar M. An insight on nanofibers assisted localized delivery of anti-cancer drugs to breast for an effective breast cancer treatment. Journal of Drug Delivery Science and Technology. 2024;93:105447 [Crossref]
16- Ramachandra D, Sudheer P. Self-micro Emulsifying Drug Delivery via Intestinal Lymphatics: A Lucrative Approach to Drug Targeting. PNT. 2023;11(3):238 [Crossref]
17- Song D, Zhang J, Hu X, Liu X. Progress in the treatment of Alzheimer's disease based on nanosized traditional Chinese medicines. J Mater Chem B. 2025;13(5):1548 [Crossref]
18- Cui J, Wen Z, Zhang W, Wu W. Recent Advances in Oral Peptide or Protein-Based Drug Liposomes. Pharmaceuticals. 2022;15(9):1072 [Crossref]
19- Gupta J, Kumar D, Gupta R, Diwakar D, Shanno K, Tripathi A, Kumar A, Kumar M. Therapeutic potential of traditional Chinese medicine loaded nanocarriers in wound management: Current status and their future perspective. Pharmacological Research - Modern Chinese Medicine. 2025;15:100622 [Crossref]
20- Singh S, Ahuja A, Ramankutty R, Ramaswamy S. Organoids Research for Colorectal Cancer: Promising Approach for Precision Medicine, their Applications and Future Perspectives. CDTH. 2024;19(7):809 [Crossref]
21- Liang Y, Liu Z, Wang P, Li Y, Wang R, Xie S. Nanoplatform-based natural products co-delivery system to surmount cancer multidrug-resistant. Journal of Controlled Release. 2021;336:396 [Crossref]
22- Sherif A, Harisa G, Alanazi F, Nasr F, Alqahtani A. PEGylated SLN as a Promising Approach for Lymphatic Delivery of Gefitinib to Lung Cancer. IJN. 2022;Volume 17:3287 [Crossref]
23- Chaturvedi S, Garg A. A comprehensive review on novel delivery approaches for exemestane. Journal of Drug Delivery Science and Technology. 2022;75:103655 [Crossref]