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Adv Pharm Bull. 2020;10(3): 389-398. doi: 10.34172/apb.2020.047
PMID: 32665897        PMCID: PMC7335989

Research Article

Self-nanoemulsifying System Optimization for Higher Terconazole Solubilization and Non-Irritant Ocular Administration

Carol Yousry 1 * ORCID, Pakinam Mohsen Zikry 2, Emad Basalious Basalious 1, Omaima Naem El-Gazayerly 1

Cited by CrossRef: 15


1- Albash R, Yousry C, Al-Mahallawi A, Alaa-Eldin A. Utilization of PEGylated cerosomes for effective topical delivery of fenticonazole nitrate: in-vitro characterization, statistical optimization, and in-vivo assessment . Drug Delivery. 2021;28(1):1 [Crossref]
2- Agarwal P, Rupenthal I. Non-aqueous formulations in topical ocular drug delivery – A paradigm shift?. Advanced Drug Delivery Reviews. 2023;198:114867 [Crossref]
3- Abdelhakeem E, El-nabarawi M, Shamma R. Effective Ocular Delivery of Eplerenone Using Nanoengineered Lipid Carriers in Rabbit Model. IJN. 2021;Volume 16:4985 [Crossref]
4- Prajapati B, Modi C, Patel U, Kendre P. Nanoemulsion based in-situ Gel for Ocular Delivery of Brimonidine Tartrate. CDTH. 2024;19(3):336 [Crossref]
5- Younes N, Sayed S, Hassan M, Ahmed S. Engineered lecithin-based proniosomes for enhanced trans-tympanic permeation: In vitro, microbiological, ex vivo and in vivo evaluation. Journal of Drug Delivery Science and Technology. 2024;96:105728 [Crossref]
6- Jaklová Dytrtová J, Kovač I, Navrátil T, Jakl M. Interactions of triazole terconazole with copper and zinc cations. Monatsh Chem. 2023;154(10):1071 [Crossref]
7- Anwar M, Boseila A, Mabrouk A, Abdelkhalek A, Amin A. Impact of Lyophilized Milk Kefir-Based Self-Nanoemulsifying System on Cognitive Enhancement via the Microbiota–Gut–Brain Axis. Antioxidants. 2024;13(10):1205 [Crossref]
8- Mohsen A. Cationic Polymeric Nanoparticles for Improved Ocular Delivery and Antimycotic Activity of Terconazole. Journal of Pharmaceutical Sciences. 2022;111(2):458 [Crossref]
9- Yousry C, Saber M, Abd-Elsalam W. A Cosmeceutical Topical Water-in-Oil Nanoemulsion of Natural Bioactives: Design of Experiment, in vitro Characterization, and in vivo Skin Performance Against UVB Irradiation-Induced Skin Damages. IJN. 2022;Volume 17:2995 [Crossref]
10- Ahmed S, Farag M, Sadek M, Aziz D. Transdermal application of diacerin loaded-terpene enriched invasomes: an approach to augment anti-edema and nociception inhibition activity. Journal of Liposome Research. 2024;:1 [Crossref]
11- Abla K, Mehanna M. Lipid-based nanocarriers challenging the ocular biological barriers: Current paradigm and future perspectives. Journal of Controlled Release. 2023;362:70 [Crossref]
12- Pires P, Fernandes M, Nina F, Gama F, Gomes M, Rodrigues L, Meirinho S, Silvestre S, Alves G, Santos A. Innovative Aqueous Nanoemulsion Prepared by Phase Inversion Emulsification with Exceptional Homogeneity. Pharmaceutics. 2023;15(7):1878 [Crossref]
13- Zingale E, Rizzo S, Bonaccorso A, Consoli V, Vanella L, Musumeci T, Spadaro A, Pignatello R. Optimization of Lipid Nanoparticles by Response Surface Methodology to Improve the Ocular Delivery of Diosmin: Characterization and In-Vitro Anti-Inflammatory Assessment. Pharmaceutics. 2022;14(9):1961 [Crossref]
14- Ali H, Hanafy A, Bafail R, Alrbyawi H, Almaghrabi M, Alahmadi Y, El Achy S. Locally Acting Budesonide-Loaded Solid Self-Microemulsifying Drug Delivery Systems (SMEDDS) for Distal Ulcerative Colitis. IJN. 2024;Volume 19:11819 [Crossref]
15- Ahmed S, Amin M, El-Korany S, Sayed S. Pronounced capping effect of olaminosomes as nanostructured platforms in ocular candidiasis management. Drug Delivery. 2022;29(1):2945 [Crossref]
16- da Silva J, Ribeiro J, de Souza L, da Silva Aquino K, Kishishita J, Sobrinho J, Leal L, de Castro W, Santana D, Bedor D. Development of the stability-indicating method, structural elucidation of new photodegradation products from terconazole by LC-MS TOF, and in vitro toxicity. Journal of Pharmaceutical and Biomedical Analysis. 2022;216:114794 [Crossref]