Kaempferol-Mediated Sensitization Enhances Chemotherapeutic Efficacy of Sorafenib Against Hepatocellular Carcinoma: An In Silico and In Vitro Approach

Bhagyalakshmi Nair ¹ , Ruby John Anto ², Sabitha M ¹, Lekshmi R. Nath ¹ *

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4- de Morais E, de Oliveira L, Farias Morais H, Souto Medeiros M, Freitas R, Rodini C, Coletta R. The Anticancer Potential of Kaempferol: A Systematic Review Based on In Vitro Studies. Cancers. 2024;16(3):585 [Crossref]

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6- Wei J, Zhao X, Long F, Tian K, Wu L. Lianhua Qingwen exerts anti-liver cancer effects and synergistic efficacy with sorafenib through PI3K/AKT pathway: Integrating network pharmacology, molecular docking, and experimental validation. Gene. 2024;912:148383 [Crossref]

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11- Cao W, Liu X, Zhang Y, Li A, Xie Y, Zhou S, Song L, Xu R, Ma Y, Cai S, Tang X, Chutipongtanate S. BEZ235 Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib by Inhibiting PI3K/AKT/mTOR and Inducing Autophagy. BioMed Research International. 2021;2021:1 [Crossref]

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20- Chandrababu G, Varkey M, Devan A, Anjaly M, Unni A, Nath L. Kaempferide exhibits an anticancer effect against hepatocellular carcinoma in vitro and in vivo. Naunyn-Schmiedeberg's Arch Pharmacol. 2023;396(10):2461 [Crossref]

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