Logo-apb
Adv Pharm Bull. 2020;10(3): 472-476. doi: 10.34172/apb.2020.058
PMID: 32665908        PMCID: PMC7335979

Short Communication

Kaempferol-Mediated Sensitization Enhances Chemotherapeutic Efficacy of Sorafenib Against Hepatocellular Carcinoma: An In Silico and In Vitro Approach

Bhagyalakshmi Nair 1 ORCID, Ruby John Anto 2, Sabitha M 1, Lekshmi R. Nath 1 * ORCID

Cited by CrossRef: 27


1- Niu C, Zhang J, Okolo P. Liver cancer wars: plant-derived polyphenols strike back. Med Oncol. 2024;41(5) [Crossref]
2- Fajriaty I, Fidrianny I, Kurniati N, Fauzi N, Mustafa S, Adnyana I. In vitro and in silico studies of the potential cytotoxic, antioxidant, and HMG CoA reductase inhibitory effects of chitin from Indonesia mangrove crab (Scylla serrata) shells. Saudi Journal of Biological Sciences. 2024;31(5):103964 [Crossref]
3- Zou S, Wu Y, Wen M, Liu J, Chen M, Yuan J, Zhou B. Potential Molecular Mechanism of Illicium simonsii Maxim Petroleum Ether Fraction in the Treatment of Hepatocellular Carcinoma. Pharmaceuticals. 2024;17(6):806 [Crossref]
4- Estevinho M, Fernandes C, Silva J, Gomes A, Afecto E, Correia J, Carvalho J. Role of ATP-binding Cassette Transporters in Sorafenib Therapy for Hepatocellular Carcinoma: An Overview. CDT. 2022;23(1):21 [Crossref]
5- de Morais E, de Oliveira L, Farias Morais H, Souto Medeiros M, Freitas R, Rodini C, Coletta R. The Anticancer Potential of Kaempferol: A Systematic Review Based on In Vitro Studies. Cancers. 2024;16(3):585 [Crossref]
6- Yu Q, Chen Z, Liu M, Meng Y, Li X, Li B, Du J. Exploring the potential targets of Sanshimao formula for hepatocellular carcinoma treatment by a method of network pharmacology combined with molecular biology. Journal of Ethnopharmacology. 2022;297:115531 [Crossref]
7- Wei J, Zhao X, Long F, Tian K, Wu L. Lianhua Qingwen exerts anti-liver cancer effects and synergistic efficacy with sorafenib through PI3K/AKT pathway: Integrating network pharmacology, molecular docking, and experimental validation. Gene. 2024;912:148383 [Crossref]
8- Hur S, Jang E, Lee J. Beneficial Actions of Orostachys japonica and Its Compounds against Tumors via MAPK Signaling Pathways. Nutrients. 2021;13(2):555 [Crossref]
9- Ouyang J, Lin W, Dong J, Yang Y, Yang H, Zhou Z, Wang R. Exploring the pharmacological mechanism of Wuzhuyu decoction on hepatocellular carcinoma using network pharmacology. World J Clin Cases. 2023;11(27):6327 [Crossref]
10- Lee H, Lee I, Park S, Jung M, Yang S, Kwon T, Lee D, Saad B. Investigation of Anti-Liver Cancer Activity of the Herbal Drug FDY003 Using Network Pharmacology. Evidence-Based Complementary and Alternative Medicine. 2022;2022:1 [Crossref]
11- Liskova A, Samec M, Koklesova L, Brockmueller A, Zhai K, Abdellatif B, Siddiqui M, Biringer K, Kudela E, Pec M, Gadanec L, Šudomová M, Hassan S, Zulli A, Shakibaei M, Giordano F, Büsselberg D, Golubnitschaja O, Kubatka P. Flavonoids as an effective sensitizer for anti-cancer therapy: insights into multi-faceted mechanisms and applicability towards individualized patient profiles. EPMA Journal. 2021;12(2):155 [Crossref]
12- Cao W, Liu X, Zhang Y, Li A, Xie Y, Zhou S, Song L, Xu R, Ma Y, Cai S, Tang X, Chutipongtanate S. BEZ235 Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib by Inhibiting PI3K/AKT/mTOR and Inducing Autophagy. BioMed Research International. 2021;2021:1 [Crossref]
13- Siniprasad P, Nair B, Balasubramaniam V, Sadanandan P, Namboori P, Nath L. Evaluation of Kaempferol as AKT Dependent mTOR Regulator via Targeting FKBP-12 in Hepatocellular Carcinoma: An In silico Approach. LDDD. 2020;17(11):1401 [Crossref]
14- Baby J, Devan A, Kumar A, Gorantla J, Nair B, Aishwarya T, Nath L. Cogent role of flavonoids as key orchestrators of chemoprevention of hepatocellular carcinoma: A review. J Food Biochem. 2021;45(7) [Crossref]
15- Felice M, Maugeri A, De Sarro G, Navarra M, Barreca D. Molecular Pathways Involved in the Anti-Cancer Activity of Flavonols: A Focus on Myricetin and Kaempferol. IJMS. 2022;23(8):4411 [Crossref]
16- Mary Y, Mary Y, Rad A, Yadav R, Celik I, Sarala S. Theoretical investigation on the reactive and interaction properties of sorafenib – DFT, AIM, spectroscopic and Hirshfeld analysis, docking and dynamics simulation. Journal of Molecular Liquids. 2021;330:115652 [Crossref]
17- Talib W, Alsayed A, Barakat M, Abu-Taha M, Mahmod A. Targeting Drug Chemo-Resistance in Cancer Using Natural Products. Biomedicines. 2021;9(10):1353 [Crossref]
18- Orabi M, Abouelela M, Darwish F, Abdelkader M, Elsadek B, Al Awadh A, Alshahrani M, Alhasaniah A, Aldabaan N, Abdelhamid R. Ceiba pentandra ethyl acetate extract improves doxorubicin antitumor outcomes against chemically induced liver cancer in rat model: a study supported by UHPLC-Q-TOF-MS/MS identification of the bioactive phytomolecules. Front Pharmacol. 2024;15 [Crossref]
19- Keerthana C, Aiswarya S, Rayginia T, Vijayan Y, James S, Shifana S, Sundaram S, Induja D, Lankalapalli R, Harikumar K, Anto R. A Novel Combinatorial Regimen Using Sorafenib and Uttroside B, A US FDA-designated ‘Orphan Drug’, for the Treatment of Hepatocellular Carcinoma. ACAMC. 2024;24(19):1431 [Crossref]
20- Hao X, Ding M, Chi C, Xu X, Zhang X, Hu M. The potential of kaempferol in digestive system tumors: recent advances and mechanistic insights. Discov Onc. 2024;15(1) [Crossref]
21- Devan A, Nair B, Nath L. Translational Phytomedicines against Cancer: Promise and Hurdles. Adv Pharm Bull. 2023;13(2):210 [Crossref]
22- Bahman A, Abaza M, Khoushaish S, Al-Attiyah R. Therapeutic efficacy of sorafenib and plant-derived phytochemicals in human colorectal cancer cells. BMC Complement Med Ther. 2023;23(1) [Crossref]
23- Chandrababu G, Varkey M, Devan A, Anjaly M, Unni A, Nath L. Kaempferide exhibits an anticancer effect against hepatocellular carcinoma in vitro and in vivo. Naunyn-Schmiedeberg's Arch Pharmacol. 2023;396(10):2461 [Crossref]
24- Sharma N, Biswas S, Al-Dayan N, Alhegaili A, Sarwat M. Antioxidant Role of Kaempferol in Prevention of Hepatocellular Carcinoma. Antioxidants. 2021;10(9):1419 [Crossref]
25- Zalpoor H, Liaghat M, Bakhtiyari M, Shapourian H, Akbari A, Shahveh S, Nabi‐Afjadi M, Minaei Beirami S, Tarhriz V. Kaempferol's potential effects againstSARS‐CoV‐2 andCOVID‐19‐associated cancer progression and chemo‐resistance. Phytotherapy Research. 2023;37(5):1731 [Crossref]
26- Santana-Lima B, Belaunde L, de Souza K, Rosa M, de Carvalho J, Machado-Jr J, Alonso-Vale M, Caseli L, Rando D, Caperuto L. Acute Kaempferol Stimulation Induces AKT Phosphorylation in HepG2 Cells. Life. 2024;14(6):764 [Crossref]
27- Shah D, Shah A, Bhattacharya S. Role of natural P-gp inhibitor in the effective delivery for chemotherapeutic agents. J Cancer Res Clin Oncol. 2023;149(1):367 [Crossref]
28- Vazhappilly C, Alsawaf S, Mathew S, Nasar N, Hussain M, Cherkaoui N, Ayyub M, Alsaid S, Thomas J, Cyril A, Ramadan W, Chelakkot A. Pharmacodynamics and safety in relation to dose and response of plant flavonoids in treatment of cancers. Inflammopharmacol. 2024; [Crossref]
29- Wang J, Ni B, Wang J, Han L, Ni X, Wang X, Cao L, Sun Q, Han X, Cui H. Research progress of Paris polyphylla in the treatment of digestive tract cancers. Discov Onc. 2024;15(1) [Crossref]