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eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2021;11(1): 56-67. doi: 10.34172/apb.2021.006
PMID: 33747852        PMCID: PMC7961215

Mini Review

Formulation and Applications of Lipid-Based Nanovehicles: Spotlight on Self-emulsifying Systems

Mohammed M. Mehanna 1 * ORCID, Amina Tarek Mneimneh 1

Cited by CrossRef: 34

1- Qu Y, Sun D, Yu Y. Interfacial engineering in Pickering emulsion photocatalytic microreactors: From mechanisms to prospects. Chemical Engineering Journal. 2022;438:135655 [Crossref]
2- Elkomy M, El Menshawe S, Kharshoum R, Abdeltwab A, Hussein R, Hamad D, Alsalahat I, Aboud H. Innovative pulmonary targeting of terbutaline sulfate-laded novasomes for non-invasive tackling of asthma: statistical optimization and comparative in vitro/in vivo evaluation. Drug Delivery. 2022;29(1):2058 [Crossref]
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7- ELTAHAN M, BAKER D, ABBAS H, ABDELMONEM R, EL-NABARAWI M, ATTIA A. GREEN SYNTHESIS OF SPIRULINA OIL-BASED NANOVESICLES AS A BIOENHANCER FOR THE INTRANASAL BRAIN TARGETING OF STATINS: CELL LINE STUDY ON HUMAN BRAIN CANCER CELL SNB-75 AND PHARMACOKINETICS ON RATS. Int J App Pharm. 2025;:391 [Crossref]
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11- Kumar M, Chawla P, Faruk A, Chawla V. Spray Drying as an Effective Method in the Development of Solid Self- Emulsifying Drug Delivery Systems. CDD. 2023;20(5):508 [Crossref]
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17- Merritt J, Richbart S, Moles E, Cox A, Brown K, Miles S, Finch P, Hess J, Tirona M, Valentovic M, Dasgupta P. Anti-Cancer Activity of Sustained Release Capsaicin Formulations. SSRN Journal. 2021; [Crossref]
18- Matei A, Caruntu C, Tampa M, Georgescu S, Matei C, Constantin M, Constantin T, Calina D, Ciubotaru D, Badarau I, Scheau C, Caruntu A. Applications of Nanosized-Lipid-Based Drug Delivery Systems in Wound Care. Applied Sciences. 2021;11(11):4915 [Crossref]
19- Shirvalilou S, Tavangari Z, Parsaei M, Sargazi S, Sheervalilou R, Shirvaliloo M, Ghaznavi H, Khoei S. The future opportunities and remaining challenges in the application of nanoparticle‐mediated hyperthermia combined with chemo‐radiotherapy in cancer. WIREs Nanomed Nanobiotechnol. 2023;15(6) [Crossref]
20- Dheek M, Chauhan S, Singh I. Nanosphere Precision: Emulsomes Revolutionizing Cancer-targeted Therapy. CDTH. 2025;20(5):699 [Crossref]
21- D'Orazio G, Ragone R, Rizzuti A, Abatematteo F, Ciampa A, Ghisa G, Casini M, Latronico M, Gallo V, Mastrorilli P, Musio B. dl‐Limonene as an Alternative Sustainable Solvent to Xylenes for the Industrial Preparation of Release Formulations. ChemistryOpen. 2025;14(5) [Crossref]
22- Singh S, Khurana K, Chauhan S, Singh I. Emulsomes: new lipidic carriers for drug delivery with special mention to brain drug transport. Futur J Pharm Sci. 2023;9(1) [Crossref]
23- Seo E, du Plessis L, Viljoen J. Solidification of Self-Emulsifying Drug Delivery Systems as a Novel Approach to the Management of Uncomplicated Malaria. Pharmaceuticals. 2022;15(2):120 [Crossref]
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25- Lee S, Lee J, Yun T, Cho J, Kim K. Enhanced Stability and Improved Oral Absorption of Enzalutamide with Self-Nanoemulsifying Drug Delivery System. IJMS. 2024;25(2):1197 [Crossref]
26- Abla K, Alamoudi M, Soliman G, Abdel-Kader M, Aldawsari M, Mehanna M. Alopecia Management Potential of Rosemary-Based Nanoemulgel Loaded with Metformin: Approach Combining Active Essential Oil and Repurposed Drug. IJN. 2025;Volume 20:605 [Crossref]
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29- Foroghi S, Sarafbidabad M, Nasiri R. Nanoemulsions of Bioactive Lipids Isolated from Cladophora Green Algae Declined NO and IL-6 Production in LPS-simulated RAW264.7 Murine Macrophage Cells. Nano LIFE. 2025;15(03) [Crossref]
30- Sharma M, Tirupathi Y, Singh R, Das A, Singh T, Tarafdar A. Emerging applications of nanotechnology in livestock: Updates and perspectives. 2025; [Crossref]
31- Sherif A, Ibrahim M. Pluronic F-68 Triblock Copolymer Architecture for a Next-Generation Self-Nanoemulsifying System: Overcoming Drug Trapping and Dosage Challenges of Candesartan Cilexetil. ACS Omega. 2025;10(37):43089 [Crossref]
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38- Wang J, Zhang Q, Yang L, Cheng Z, Wang C, Song R, Dai H, Zhang X. Lipid‐Based Nanoplatforms in Hepatology: From Rational Design to Clinical Translation Challenges. MedComm – Biomaterials and Applications. 2025;4(3) [Crossref]
39- SAPIUN Z, IMRAN A, ASWAD A, USMAN NUR M, YSRAFIL Y, PANIGORO N, UTINA N, ALIWU I. MODIFYING FRACTION EXTRACTED FROM SESEWANUA (CLERODENDRUM FRAGRANS WILD) LEAVES IN SNEDDS PREPARATIONS: CHARACTERIZATION AND BIOAVAILABILITY TEST. Int J App Pharm. 2024;:255 [Crossref]
40- Abla K, Mneimneh A, Allam A, Mehanna M. Application of Box-Behnken Design in the Preparation, Optimization, and In-Vivo Pharmacokinetic Evaluation of Oral Tadalafil-Loaded Niosomal Film. Pharmaceutics. 2023;15(1):173 [Crossref]
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42- Nanda G, Patel M, Dua K, Singh S, Patel R. Novel lipid-based nanocarrier of nitrofurantoin for improved oral bioavailability and reduced variability in absorption. Journal of Dispersion Science and Technology. 2024;45(14):2536 [Crossref]
43- Akl M, Eldeen M, Kassem A. Beyond Skin Deep: Phospholipid-Based Nanovesicles as Game-Changers in Transdermal Drug Delivery. AAPS PharmSciTech. 2024;25(6) [Crossref]
44- Noor L, Hafeez A, Rahman M, Vishwakarma K, Kapoor A, Ara N, Aqeel R. Demystifying the Potential of Embelin-Loaded Nanoformulations: a Comprehensive Review. AAPS PharmSciTech. 2024;25(8) [Crossref]