Postbiotics as Promising Tools for Cancer Adjuvant Therapy

Aziz Homayouni Rad ¹ , Leili Aghebati Maleki ² , Hossein Samadi Kafil ³ , Hamideh Fathi Zavoshti ⁴ , Amin Abbasi ⁵ *

Cited by CrossRef: 26

1- Abbasi A, Aghebati-Maleki L, Homayouni-Rad A. The promising biological role of postbiotics derived from probiotic Lactobacillus species in reproductive health. Critical Reviews in Food Science and Nutrition. 2022;62(32):8829 [Crossref]

2- Homayouni-Rad A, Abbasi A, Soleimani R, Pouraga B. Could Postbiotics Substitute Probiotics?. CNF. 2023;19(7):670 [Crossref]

3- Sabahi S, Homayouni Rad A, Aghebati-Maleki L, Sangtarash N, Ozma M, Karimi A, Hosseini H, Abbasi A. Postbiotics as the new frontier in food and pharmaceutical research. Critical Reviews in Food Science and Nutrition. 2023;63(26):8375 [Crossref]

4- Abbasi A, Rad A, Ghasempour Z, Sabahi S, Kafil H, Hasannezhad P, Rahbar Saadat Y, Shahbazi N. The biological activities of postbiotics in gastrointestinal disorders. Critical Reviews in Food Science and Nutrition. 2022;62(22):5983 [Crossref]

5- Soleimani R, Shokouhian S, Houshyar J, Khani N, Abachi S, Milani P, Panahi E, Homayouni-Rad A. Postbiotic Bioactive Packaging Systems: A Review. CNF. 2024;20(3):296 [Crossref]

6- Wang S, Wang P, Wang D, Shen S, Wang S, Li Y, Chen H. Postbiotics in inflammatory bowel disease: efficacy, mechanism, and therapeutic implications. J Sci Food Agric. 2025;105(2):721 [Crossref]

7- Wang L, Cao Z, Zhang L, Li J, Lv W. The Role of Gut Microbiota in Some Liver Diseases: From an Immunological Perspective. Front Immunol. 2022;13 [Crossref]

8- Blazheva D, Mihaylova D, Averina O, Slavchev A, Brazkova M, Poluektova E, Danilenko V, Krastanov A. Antioxidant Potential of Probiotics and Postbiotics: A Biotechnological Approach to Improving Their Stability. Russ J Genet. 2022;58(9):1036 [Crossref]

9- Bi C, Xiao G, Liu C, Yan J, Chen J, Si W, Zhang J, Liu Z. Molecular Immune Mechanism of Intestinal Microbiota and Their Metabolites in the Occurrence and Development of Liver Cancer. Front Cell Dev Biol. 2021;9 [Crossref]

10- Feizi H, Plotnikov A, Rezaee M, Ganbarov K, Kamounah F, Nikitin S, Kadkhoda H, Gholizadeh P, Pagliano P, Kafil H. Postbiotics versus probiotics in early-onset colorectal cancer. Critical Reviews in Food Science and Nutrition. 2024;64(11):3573 [Crossref]

11- Köktürk S, Yardimci H. Postbiotics and their therapeutic effects: a review. 2024;35(4):175 [Crossref]

12- Abbasi A, Hajipour N, Hasannezhad P, Baghbanzadeh A, Aghebati-Maleki L. Potential in vivo delivery routes of postbiotics. Critical Reviews in Food Science and Nutrition. 2022;62(12):3345 [Crossref]

13- Sheykhsaran E, Abbasi A, Ebrahimzadeh Leylabadlo H, Sadeghi J, Mehri S, Naeimi Mazraeh F, Feizi H, Bannazadeh Baghi H. Gut microbiota and obesity: an overview of microbiota to microbial-based therapies. 2023;99(1171):384 [Crossref]

14- Khani N, Abedi Soleimani R, Homayouni Rad A. Characterization and Antimicrobial Activity of Postbiotic from Lactobacillus Acidophilus LA5 on Staphylococcus Aureus in Food Model and In vitro. CNF. 2025;21(3):379 [Crossref]

15- Sepordeh S, Jafari A, Bazzaz S, Abbasi A, Aslani R, Houshmandi S, Rad A. Postbiotic as Novel Alternative Agent or Adjuvant for the Common Antibiotic Utilized in the Food Industry. CPB. 2024;25(10):1245 [Crossref]

16- Layús B, Gerez C, Rodriguez A. Development of an ophthalmic formulation with a postbiotic of Lactiplantibacillus plantarum CRL 759. BM. 2022;13(5):417 [Crossref]

17- Kaya Y, Şengül M, Dertli E. Lactobacillus spp. Tarafından Üretilen Postbiyotiklerin Gıdalarda Biyokoruyucu Olarak Kullanımı: Probiyotiklerden Postbiyotiklere Geçiş. 2024;14(4):1562 [Crossref]

18- Appunni S, Rubens M, Ramamoorthy V, Tonse R, Saxena A, McGranaghan P, Kaiser A, Kotecha R. Emerging Evidence on the Effects of Dietary Factors on the Gut Microbiome in Colorectal Cancer. Front Nutr. 2021;8 [Crossref]

19- Ibrahim Z, Khan N, Siddiqui R, Qaisar R, Marzook H, Soares N, Elmoselhi A. Gut matters in microgravity: potential link of gut microbiota and its metabolites to cardiovascular and musculoskeletal well-being. Nutr Metab (Lond). 2024;21(1) [Crossref]

20- Babu A, Guruprasath N, Adeyeye S, Sankarganesh P, Kumar A, Sivapriya T. A Critical Analysis of Postbiotics: Exploring their Potential Impact on the Health and Food Industries. J Pure Appl Microbiol. 2023;17(4):2041 [Crossref]

21- Ghaffari S, Abbasi A, Somi M, Moaddab S, Nikniaz L, Kafil H, Ebrahimzadeh Leylabadlo H. Akkermansia muciniphila : from its critical role in human health to strategies for promoting its abundance in human gut microbiome . Critical Reviews in Food Science and Nutrition. 2023;63(25):7357 [Crossref]

22- Arora R, Kaur R, Babbar R, Dhingra S, Dhingra A, Grewal A. Evolving Advances in the Cosmetic use of Probiotics and Postbiotics: Health, Regulatory and Marketing Aspects. CPB. 2024;25(11):1349 [Crossref]

23- Jeong G. Recently Progressed Postbiotics as Nutraceuticals. Food Suppl Biomater Health. 2021;1(3) [Crossref]

24- Franco W. Postbiotics and parabiotics derived from bacteria and yeast: current trends and future perspectives. CyTA - Journal of Food. 2024;22(1) [Crossref]

25- Cullin N, Azevedo Antunes C, Straussman R, Stein-Thoeringer C, Elinav E. Microbiome and cancer. Cancer Cell. 2021;39(10):1317 [Crossref]

26- Layús B, Gómez M, Cazorla S, Rodriguez A. A Postbiotic Formulation of Lactiplantibacillus plantarum CRL 759 Attenuates Endotoxin Induced Uveitis . Ocular Immunology and Inflammation. 2024;32(9):1973 [Crossref]

27- El-Saadony M, Saad A, Korma S, Salem H, Abd El-Mageed T, Alkafaas S, Elsalahaty M, Elkafas S, Mosa W, Ahmed A, Mathew B, Albastaki N, Alkuwaiti A, El-Tarabily M, AbuQamar S, El-Tarabily K, Ibrahim S. Garlic bioactive substances and their therapeutic applications for improving human health: a comprehensive review. Front Immunol. 2024;15 [Crossref]

28- Xie W, Sharma A, Kaushik H, Sharma L, Sharma N, Anwer M, Sachdeva M, Elossaily G, Zhang Y, Pillappan R, Kaur M, Behl T, Shen B, Singla R. Shaping the future of gastrointestinal cancers through metabolic interactions with host gut microbiota. Heliyon. 2024;10(15):e35336 [Crossref]