Studying the Effect of Amino Acid Substitutions in the M2 Ion Channel of the Influenza Virus on the Antiviral Activity of the Aminoadamantane Derivative In Vitro and In Silico

Timur Mansurovich Garaev ¹ * , Artyom Irorevich Odnovorov ² , Alexander Aleksandrovich Lashkov ³ , Tatiana Vladimirovna Grebennikova ¹ , Marina Pavlovna Finogenova ¹ , Galina Kadymovna Sadykova ¹ , Alexei Gennadievich Prilipov ¹ , Tatiana Anatol'evna Timofeeva ¹, Sergey Vadimovich Rubinsky ³, Svetlana Nikolaevna Norkina ¹, Marina Mikhailovna Zhuravleva ¹

Cited by CrossRef: 8

1- Avdeeva V, Garaev T, Malinina E, Zhizhin K, Kuznetsov N. Physiologically Active Compounds Based on Membranotropic Cage Carriers–Derivatives of Adamantane and Polyhedral Boron Clusters (Review). Russ J Inorg Chem. 2022;67(1):28 [Crossref]

2- Garaev T, Yudin I, Breslav N, Grebennikova T, Avdeeva V, Goeva L, Golubev A, Kubasov A, Nikiforova S, Malinina E. Increasing the aqueous solubility of N-acyl-substituted amino acid esters as inhibitors of viral replication in vitro using iron(II) ions. Tetrahedron. 2024;151:133785 [Crossref]

3- Garaev T, Grebennikova T, Lebedeva V, Avdeeva V, Larichev V. Compounds based on Adamantyl-substituted Amino Acids and Peptides as Potential Antiviral Drugs Acting as Viroporin Inhibitors. CPD. 2024;30(12):912 [Crossref]

4- Lashkov A, Garaev T, Rubinsky S, Samygina V. Structural Basis for Interactions between Influenza A Virus M2 Proton Channel and Adamantane-Based Antiviral Drugs. Kristallografiâ. 2023;68(6):845 [Crossref]

5- Garaev Т, Yudin I, Breslav N, Savochkina Т, Krepkaya А, Grebennikova Т, Nikiforova S, Myshletsov I, Avdeeva V, Malinina Е. Increasing the water solubility of N-acyl-substituted amino acid esters as inhibitors of the replication of modern influenza A virus strains in vitro due to zinc(II) complexation. Žurnal neorganičeskoj himii. 2024;69(5):736 [Crossref]

6- Papadourakis M, Sinenka H, Matricon P, Hénin J, Brannigan G, Pérez-Benito L, Pande V, van Vlijmen H, de Graaf C, Deflorian F, Tresadern G, Cecchini M, Cournia Z. Alchemical Free Energy Calculations on Membrane-Associated Proteins. J Chem Theory Comput. 2023;19(21):7437 [Crossref]

7- Garaev T, Yudin I, Breslav N, Savochkina T, Krepkaya A, Grebennikova T, Nikiforova S, Myshletsov I, Avdeeva V, Malinina E. Increasing the Water Solubility of N-Acyl-Substituted Amino Acid Esters as Inhibitors of the Replication of Modern Influenza A Virus Strains In Vitro by Zinc(II) Complexation. Russ J Inorg Chem. 2024; [Crossref]

8- Garaev T, Grebennikova T, Avdeeva V, Lebedeva V, Larichev V. Antiviral properties of synthetic histidine derivatives containing membranotropic volumetrical carbocycles in their molecule against SARS-CoV-2 virus in vitro. Problems of Virology. 2023;68(1):18 [Crossref]

9- Lashkov A, Garaev T, Rubinsky S, Samygina V. Structural Basis for Interactions between Influenza A Virus M2 Proton Channel and Adamantane-Based Antiviral Drugs. Crystallogr Rep. 2023;68(6):843 [Crossref]