Understanding Hyaluronan Receptor (CD44) Interaction, HA-CD44 Activated Potential Targets in Cancer Therapeutics

Gul-e-Saba Chaudhry ¹ * , Abdah Akim ², Muhammad Naveed Zafar ³, Naila Safdar ⁴, Yeong Yik Sung ¹, Tengku Sifzizul Tengku Muhammad ¹

Cited by CrossRef: 39

1- Matějková N, Korecká L, Šálek P, Kočková O, Pavlova E, Kašparová J, Obořilová R, Farka Z, Frolich K, Adam M, Carrillo A, Šinkorová Z, Bílková Z. Hyaluronic Acid Nanoparticles with Parameters Required for In Vivo Applications: From Synthesis to Parametrization. Biomacromolecules. 2024;25(8):4934 [Crossref]

2- Kim E, Lee S, Kim Y. 1,2,3,4,6-Penta-O-galloyl-β-D-glucose Inhibits CD44v3, a cancer stem cell marker, by regulating its transcription factor, in human pancreatic cancer cell line. Animal Cells and Systems. 2022;26(6):328 [Crossref]

3- Yang S, Wong K, Hua P, He C, Yu H, Shao D, Shi Z, Chen M. ROS-Responsive Fluorinated Polyethyleneimine Vector to Co-Deliver shMTHFD2 and shGPX4 Plasmids Induces Ferroptosis and Apoptosis for Cancer Therapy. SSRN Journal. 2021; [Crossref]

4- Trouvilliez S, Cicero J, Lévêque R, Aubert L, Corbet C, Van Outryve A, Streule K, Angrand P, Völkel P, Magnez R, Brysbaert G, Mysiorek C, Gosselet F, Bourette R, Adriaenssens E, Thuru X, Lagadec C, de Ruyck J, Orian-Rousseau V, Le Bourhis X, Toillon R. Direct interaction of TrkA/CD44v3 is essential for NGF-promoted aggressiveness of breast cancer cells. J Exp Clin Cancer Res. 2022;41(1) [Crossref]

5- Kondapaneni R, Gurung S, Nakod P, Goodarzi K, Yakati V, Lenart N, Rao S. Glioblastoma mechanobiology at multiple length scales. Biomaterials Advances. 2024;160:213860 [Crossref]

6- Shi Y, Liao J, Zhang C, Wu Q, Hu S, Yang T, Liu J, Zhu Z, Zhu W, Wang Q. Cascade-responsive size/charge bidirectional-tunable nanodelivery penetrates pancreatic tumor barriers. Chem Sci. 2024;15(38):15647 [Crossref]

7- Chen C, Zhang H, Han J, Yang L, Li S, Jia Q, Fang J, Ling P, Wang S. Synthesis and antitumor activity of ultra-low molecular weight hyaluronic acid-decorated camptothecin conjugates. Carbohydrate Polymers. 2025;351:123144 [Crossref]

8- Hu M, Zhang R, Yang J, Zhao C, Liu W, Huang Y, Lyu H, Xiao S, Guo D, Zhou C, Tang J. The role of N-glycosylation modification in the pathogenesis of liver cancer. Cell Death Dis. 2023;14(3) [Crossref]

9- Chaudhry G, C S T, Mohamed Zin N, Yik Sung Y, Tengku Muhammad T, AWM E. Antibacterial activity of Tilapia Fish Scales derived Chitosan; Future towards Biomedicines. RJPT. 2022;:4627 [Crossref]

10- You X, Liu H, Chen Y, Zhao G. Multifunctional Liposomes Co-Modified with Ginsenoside Compound K and Hyaluronic Acid for Tumor-Targeted Therapy. Polymers. 2024;16(3):405 [Crossref]

11- Tatode A, Agrawal P, Taksande J, Qutub M, Premchandani T, Umekar M, Danao K. Role of folate receptor and CD44 in targeting of docetaxel and paclitaxel fabricated conjugates for efficient cancer therapy. Journal of Medicine, Surgery, and Public Health. 2025;5:100163 [Crossref]

12- Tolg C, Messam B, McCarthy J, Nelson A, Turley E. Hyaluronan Functions in Wound Repair That Are Captured to Fuel Breast Cancer Progression. Biomolecules. 2021;11(11):1551 [Crossref]

13- Cao L, Fang H, Yan D, Wu X, Zhang J, Chang M. CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response. Commun Biol. 2022;5(1) [Crossref]

14- Chen X, Argandona S, Melle F, Rampal N, Fairen-Jimenez D. Advances in surface functionalization of next-generation metal-organic frameworks for biomedical applications: Design, strategies, and prospects. Chem. 2024;10(2):504 [Crossref]

15- Wang H, Shao W, Lu X, Gao C, Fang L, Yang X, Zhu P. Synthesis, characterization, and in vitro anti-tumor activity studies of the hyaluronic acid-mangiferin-methotrexate nanodrug targeted delivery system. International Journal of Biological Macromolecules. 2023;239:124208 [Crossref]

16- Jin H, Li M, Tian F, Yu F, Zhao W. An Overview of Antitumour Activity of Polysaccharides. Molecules. 2022;27(22):8083 [Crossref]

17- Buruiană A, Gheban B, Gheban-Roșca I, Georgiu C, Crișan D, Crișan M. The Tumor Stroma of Squamous Cell Carcinoma: A Complex Environment That Fuels Cancer Progression. Cancers. 2024;16(9):1727 [Crossref]

18- Xu Y, Bai Z, Lan T, Fu C, Cheng P. CD44 and its implication in neoplastic diseases. MedComm. 2024;5(6) [Crossref]

19- Simińska‐Stanny J, Podstawczyk D, Delporte C, Nie L, Shavandi A. Hyaluronic Acid Role in Biomaterials Prevascularization. Adv Healthcare Materials. 2024;13(30) [Crossref]

20- Chen D, Liu X, Lu X, Tian J. Nanoparticle drug delivery systems for synergistic delivery of tumor therapy. Front Pharmacol. 2023;14 [Crossref]

21- Saraf S, Jain S. pH-sensitive liposomes bearing a chemotherapeutic agent and a natural apoptosis modulator for effective intracellular delivery to the solid tumor. Drug Deliv and Transl Res. 2023;13(12):2961 [Crossref]

22- Chaudhry G, Akim A, Yik Sung Y, Tengku Muhammad T. Polymeric Nanoparticles methods of preparation and Drug Release Models: Effectiveness towards Drug Delivery Systems. RJPT. 2022;:2883 [Crossref]

23- Tsen H, Sun T, Lai T, Huang W, Wang H, Lu T, Wang T. Cisplatin-activated and hemoglobin-mediated injectable hydrogel system for antitumor chemodynamic and chemotherapy. Biomedicine & Pharmacotherapy. 2024;175:116713 [Crossref]

24- Sun X, He Z, Lu R, Liu Z, Chiampanichayakul S, Anuchapreeda S, Jiang J, Tima S, Zhong Z. Hyaluronic acid-modified liposomes Potentiated in-vivo anti-hepatocellular carcinoma of icaritin. Front Pharmacol. 2024;15 [Crossref]

25- Xue G, Tang L, Pan X, Li S, Zhao J. Hyaluronic acid–targeted topotecan liposomes improve therapeutic efficacy against lung cancer in animals. Front Oncol. 2024;14 [Crossref]

26- Lu Z, Ma L, Mei L, Ren K, Li M, Zhang L, Liu X, He Q. Micellar nanoparticles inhibit the postoperative inflammation, recurrence and pulmonary metastasis of 4T1 breast cancer by blocking NF-κB pathway and promoting MDSCs depletion. International Journal of Pharmaceutics. 2022;628:122303 [Crossref]

27- Inoue A, Ohnishi T, Nishikawa M, Ohtsuka Y, Kusakabe K, Yano H, Tanaka J, Kunieda T. A Narrative Review on CD44’s Role in Glioblastoma Invasion, Proliferation, and Tumor Recurrence. Cancers. 2023;15(19):4898 [Crossref]

28- Li N, Zhang X, Zhou J, Li W, Shu X, Wu Y, Long M. Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer. Advanced Drug Delivery Reviews. 2022;188:114448 [Crossref]

29- Chen R, Lin X, Tao P, Wan Y, Wen X, Shi J, Li J, Huang C, Zhou J, Xie N, Han C. Targeted nanoprobe for magnetic resonance imaging-guided enhanced antitumor via synergetic photothermal/immunotherapy. Journal of Colloid and Interface Science. 2025;678:937 [Crossref]

30- Avsharian L, Loganathan S, Ebelt N, Shalamzari A, Rodarte Muñoz I, Manuel E. Tumor-Colonizing E. coli Expressing Both Collagenase and Hyaluronidase Enhances Therapeutic Efficacy of Gemcitabine in Pancreatic Cancer Models. Biomolecules. 2024;14(11):1458 [Crossref]

31- Matsuzaka Y, Yashiro R. Classification and Molecular Functions of Heparan Sulfate Proteoglycans and Their Molecular Mechanisms with the Receptor. Biologics. 2024;4(2):105 [Crossref]

32- Vy Phan T, Mondal S, Santhamoorthy M, Truong T, Nguyen T, Oh J. Hyaluronic acid functionalized iron–platinum nanoparticles for photothermal therapy and photoacoustic imaging. Colloids and Surfaces B: Biointerfaces. 2024;238:113910 [Crossref]

33- Zhu H, Huang D, Wang J, Zhao Y, Sun L. Viral Mimicking Polyplexes as Hierarchical Unpacking Vectors for Rheumatoid Arthritis Treatment. Advanced Science. 2024;11(32) [Crossref]

34- Daku A, Solehah Mohd-Rosdan B, Mohtar N, Nurul A. Advances in polysaccharide-based formulations for intranasal drug delivery: A review. Journal of Drug Delivery Science and Technology. 2024;101:106266 [Crossref]

35- Xie Y, Yang Z, Shen H, Chen J, Weitz D, Chen D, Sheng J, Liang T. Interfacial Engineering of Biocompatible Nanocapsules for Near‐Infrared‐Triggered Drug Release and Photothermal Therapy. Advanced Science. 2024; [Crossref]

36- Zhang X, Zhang X, Li Y, Zhang Y. Applications of Light-Based 3D Bioprinting and Photoactive Biomaterials for Tissue Engineering. Materials. 2023;16(23):7461 [Crossref]

37- Hu K, Li X, Tan Z, Shi Y. Simple ROS-responsive micelles loaded Shikonin for efficient ovarian cancer targeting therapy by disrupting intracellular redox homeostasis. European Journal of Pharmaceutics and Biopharmaceutics. 2024;204:114525 [Crossref]

38- Alsabbagh R, Ahmed M, Alqudah M, Hamoudi R, Harati R. Insights into the Molecular Mechanisms Mediating Extravasation in Brain Metastasis of Breast Cancer, Melanoma, and Lung Cancer. Cancers. 2023;15(8):2258 [Crossref]

39- Chen Y, Wang Z, Wang X, Su M, Xu F, Yang L, Jia L, Zhang Z. Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin. IJN. 2022;Volume 17:4227 [Crossref]

40- Kesharwani P, Ma R, Sang L, Fatima M, Sheikh A, Abourehab M, Gupta N, Chen Z, Zhou Y. Gold nanoparticles and gold nanorods in the landscape of cancer therapy. Mol Cancer. 2023;22(1) [Crossref]

41- Du T, Wu Z, Wu Y, Liu Y, Song Y, Ma L. CD44 Is Associated with Poor Prognosis of ccRCC and Facilitates ccRCC Cell Migration and Invasion through HAS1/MMP9. Biomedicines. 2023;11(7):2077 [Crossref]

42- Nitti P, Narayanan A, Pellegrino R, Villani S, Madaghiele M, Demitri C. Cell-Tissue Interaction: The Biomimetic Approach to Design Tissue Engineered Biomaterials. Bioengineering. 2023;10(10):1122 [Crossref]

43- Yang Z, Zhou Y, Liu X, Ren L, Liu X, Yun R, Jia L, Ren X, Wang Y, Sun Y, Li J, Gao D, Tian Z. Mitochondrial-uncoupling nanomedicine for self-heating and immunometabolism regulation in cancer cells. Biomaterials. 2025;314:122883 [Crossref]