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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2021;11(2): 261-266. doi: 10.34172/apb.2021.038
PMID: 33880347        PMCID: PMC8046405

Review Article

Time to Change Theory; Medical Leech from a Molecular Medicine Perspective Leech Salivary Proteins Playing a Potential Role in Medicine

Amir Shakouri 1 * ORCID, Uwe Wollina 2 ORCID

Cited by CrossRef: 7

1- Özdemir S, Ayhan H. Anticancer Potential of Lyophilised Medicinal Leech (Hirudo verbana) of Saliva Extract Against Pancreatic Cancer (MIA PaCa-2) Cell Lines. 2025;10(2):167 [Crossref]
2- Shakouri A, Kahroba H, Hamishekar H, Abdolalizadeh J. Nanoencapsulation of Hirudo medicinalis proteins in liposomes as a nanocarrier for inhibiting angiogenesis through targeting VEGFA in the Breast cancer cell line (MCF-7). Bioimpacts. 2021;12(2):115 [Crossref]
3- Witwit L. Cytotoxic effect of silver nanoparticles biosynthesized from Hirudo medicinalis saliva on HepG2 cells. Rev Clin Pharmacol Pharmacokinet, Int Ed. 2024;38(Sup2):177 [Crossref]
4- Ceylan M, Çetinkaya O, Bulut C. Acute Toxicity of Zinc on Southern Medicinal Leech, Hirudo verbana Carena, 1820. 2021;17(3):421 [Crossref]
5- Çoruk F, Ayhan H. Integrative Treatment Method in Veterinary Medicine: Hirudotherapy. 2025;9(1):75 [Crossref]
6- Ghazzay M, Al-Hilli E. The Medical Benefits of Medicinal Leeches. ijbea. 2024;3(3):212 [Crossref]
7- Marquez-Gil K, Mesa E, Kouka N, Fonarov I, Casadesus D. Medicinal Leeches to Aid in Post-procedural Hematoma Evacuation. 2023; [Crossref]
8- Sun Y, Cheng G, Du L, Gan Y, Li B, Yan S, Shao M, Jin H, Li S. Chuanzhitongluo capsule ameliorates microcirculatory dysfunction in rats: Efficacy evaluation and metabolic profiles. Front Pharmacol. 2022;13 [Crossref]
9- Turlaev M, Shikhnebiev A, Kardanova Z, Rokhoev M, Mutigullina K, Zakiev R, Baklanova O, Baklanov I. Socio-Economic Aspects of the Development of Hirudotherapy in Russia. Entomol Appl Sci Lett. 2022;9(4):79 [Crossref]
10- Tural Ö, Ayhan H. The Anti-Proliferative Activity of Lyophilised Medicinal Leech (Hirudo Verbana) Saliva Extract on Breast Cancer Cell Line (MCF-7). 2024;9(4):508 [Crossref]