A Novel Approach for Development of Intraocular Biodegradable Ranibizumab Implant: A Solution for Stability of Protein Activity

Fatemeh Dadgar Pakdel ^1,2 , Ahmad Mirshahi ³, Payam Zahedi ⁴, Kazem Mohammad ⁵, Farkhondeh Hemmati ⁶, Javad Dadgar Pakdel ⁷, Mohammad Hossein Nicknam ^1,8 * , Farid Abedin Dorkoosh ^2,9 *

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1- Wang L, Zhang H. Ocular barriers as a double-edged sword: preventing and facilitating drug delivery to the retina. Drug Deliv and Transl Res. 2023;13(2):547 [Crossref]

2- Chacin Ruiz E, Swindle-Reilly K, Ford Versypt A. Experimental and mathematical approaches for drug delivery for the treatment of wet age-related macular degeneration. Journal of Controlled Release. 2023;363:464 [Crossref]

3- Wang H, Song M, Xu J, Liu Z, Peng M, Qin H, Wang S, Wang Z, Liu K. Long-Acting Strategies for Antibody Drugs: Structural Modification, Controlling Release, and Changing the Administration Route. Eur J Drug Metab Pharmacokinet. 2024;49(3):295 [Crossref]