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Adv Pharm Bull. 2022;12(3): 531-540. doi: 10.34172/apb.2022.056

PMID: 35935049 PMCID: PMC9348537

Research Article

Design and Development of Antibacterial/Anti-inflammatory Dual Drug-Loaded Nanofibrous Inserts for Ophthalmic Sustained Delivery of Gentamicin and Methylprednisolone: In Vitro Bioassay, Solvent, and Method Effects’ Evaluation

Shahla Mirzaeei ^1,2 * , Donya Barfar ^3,4

Cited by CrossRef: 11

1- Lv J, Ma S, Shan D. Precision Nanotherapy for Spinal Cord Injury: Modulating SLC16A3 With Methylprednisolone-Loaded Nanoparticles. Neurospine. 2025;22(2):478 [Crossref]

2- Zuhour M, Güneş C, Fındık S, Dündar M, Gök O, Altuntaş Z. Effect of methylprednisolone loaded poly lactic-co-glycolic acid (PLGA) bioabsorbable nanofibers on tendon healing and adhesion formation. Journal of Drug Delivery Science and Technology. 2023;89:104988 [Crossref]

3- Ezzati A, Nokhodchi A, saeedi M, Ziaei N, Mirzaeei S. Fabrication and evaluating the potentials of minocycline hydrochloride-loaded nanofibrous membranes in periodontal guided tissue regeneration: In vivo release and biocompatibility analysis. Journal of Drug Delivery Science and Technology. 2023;88:104919 [Crossref]

4- Shangguan W, Li S, Cao L, Wei M, Wang Z, Xu H. Electrospinning and nanofibers: Building drug delivery systems and potential in pesticide delivery. Materials Today Communications. 2022;33:104399 [Crossref]

5- Gunduz O, Ulag S. Gentamicin and fluconazole loaded electrospun polymethylmethacrylate (PMMA) fibers as a novel platform for the treatment of corneal keratitis. International Journal of Polymeric Materials and Polymeric Biomaterials. 2023;72(12):995 [Crossref]

6- Sahu D, Rath G, Gupta G. Addressing ocular drug delivery challenges with solid nanofiber variants and supramolecular nanofibrous gel composite. Journal of Drug Delivery Science and Technology. 2024;94:105476 [Crossref]

7- Karami A, Mirzaeei S, Rezaei L, Nokhodchi A. Development and Evaluation of Polymethacrylate-Based Ophthalmic Nanofiber Inserts Containing Dual Drug-Loaded Dorzolamide and Timolol: In Vivo Study in Rabbit’s Eye. Biomedicines. 2025;13(1):200 [Crossref]

8- Omer S, Zelkó R. A Systematic Review of Drug-Loaded Electrospun Nanofiber-Based Ophthalmic Inserts. Pharmaceutics. 2021;13(10):1637 [Crossref]

9- Pisani S, Mauri V, Negrello E, Friuli V, Genta I, Dorati R, Bruni G, Marconi S, Auricchio F, Pietrabissa A, Benazzo M, Conti B. Hybrid 3D-Printed and Electrospun Scaffolds Loaded with Dexamethasone for Soft Tissue Applications. Pharmaceutics. 2023;15(10):2478 [Crossref]

10- Taghe S, Mirzaeei S, Hosseinkhani T. Design and development of dual drug-loaded nanofibrous inserts for ophthalmic sustained delivery of AMK and VAN: Pharmacokinetic study in rabbit’s eye. International Journal of Pharmaceutics. 2024;656:124056 [Crossref]

11- Taghe S, Mirzaeei S, Pakdaman N, Kazemi A, Nokhodchi A. Macrolide-loaded nanofibrous inserts with polycaprolactone and cellulose acetate base for sustained ocular delivery: Pharmacokinetic study in Rabbit’s eye. International Journal of Pharmaceutics. 2024;665:124699 [Crossref]

12- Chiang M, Chern E. More than Antibiotics: Latest Therapeutics in the Treatment and Prevention of Ocular Surface Infections. JCM. 2022;11(14):4195 [Crossref]