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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2022;12(3): 531-540. doi: 10.34172/apb.2022.056
PMID: 35935049        PMCID: PMC9348537

Research Article

Design and Development of Antibacterial/Anti-inflammatory Dual Drug-Loaded Nanofibrous Inserts for Ophthalmic Sustained Delivery of Gentamicin and Methylprednisolone: In Vitro Bioassay, Solvent, and Method Effects’ Evaluation

Shahla Mirzaeei 1,2 * ORCID, Donya Barfar 3,4 ORCID

Cited by CrossRef: 11

1- Lv J, Ma S, Shan D. Precision Nanotherapy for Spinal Cord Injury: Modulating SLC16A3 With Methylprednisolone-Loaded Nanoparticles. Neurospine. 2025;22(2):478 [Crossref]
2- Zuhour M, Güneş C, Fındık S, Dündar M, Gök O, Altuntaş Z. Effect of methylprednisolone loaded poly lactic-co-glycolic acid (PLGA) bioabsorbable nanofibers on tendon healing and adhesion formation. Journal of Drug Delivery Science and Technology. 2023;89:104988 [Crossref]
3- Ezzati A, Nokhodchi A, saeedi M, Ziaei N, Mirzaeei S. Fabrication and evaluating the potentials of minocycline hydrochloride-loaded nanofibrous membranes in periodontal guided tissue regeneration: In vivo release and biocompatibility analysis. Journal of Drug Delivery Science and Technology. 2023;88:104919 [Crossref]
4- Shangguan W, Li S, Cao L, Wei M, Wang Z, Xu H. Electrospinning and nanofibers: Building drug delivery systems and potential in pesticide delivery. Materials Today Communications. 2022;33:104399 [Crossref]
5- Gunduz O, Ulag S. Gentamicin and fluconazole loaded electrospun polymethylmethacrylate (PMMA) fibers as a novel platform for the treatment of corneal keratitis. International Journal of Polymeric Materials and Polymeric Biomaterials. 2023;72(12):995 [Crossref]
6- Sahu D, Rath G, Gupta G. Addressing ocular drug delivery challenges with solid nanofiber variants and supramolecular nanofibrous gel composite. Journal of Drug Delivery Science and Technology. 2024;94:105476 [Crossref]
7- Mirzaeei S, Eidizadeh M, Khosravi A, Bagheri M, Taghe S. Efficacy of a Ceftazidime-loaded Nanofiber Insert in Treating Pseudomonas aeruginosa-induced Corneal Ulcers: An Animal Model. JOVR. 2025;20:1 [Crossref]
8- Karami A, Mirzaeei S, Rezaei L, Nokhodchi A. Development and Evaluation of Polymethacrylate-Based Ophthalmic Nanofiber Inserts Containing Dual Drug-Loaded Dorzolamide and Timolol: In Vivo Study in Rabbit’s Eye. Biomedicines. 2025;13(1):200 [Crossref]
9- Omer S, Zelkó R. A Systematic Review of Drug-Loaded Electrospun Nanofiber-Based Ophthalmic Inserts. Pharmaceutics. 2021;13(10):1637 [Crossref]
10- seyedi N, Taymouri S, allafchian A, Minaiyan M, Omidi E, Varshosaz J. Fabrication and in-vitro and in-vivo evaluation of polyacrylonitrile and polyethylene oxide nanofibers loaded with resveratrol and silver nanoparticles for skin wound healing application . J Biomater Appl. 2025; [Crossref]
11- Darwesh A, Elkanayati R, Mortada A, Abdelhakk H, Safak A, Maniruzzaman M. Design of experiment optimization of hydrocortisone ocular minitablets via vacuum compression molding with scalability assessment by fused deposition modeling. International Journal of Pharmaceutics. 2025;:126422 [Crossref]
12- Pisani S, Mauri V, Negrello E, Friuli V, Genta I, Dorati R, Bruni G, Marconi S, Auricchio F, Pietrabissa A, Benazzo M, Conti B. Hybrid 3D-Printed and Electrospun Scaffolds Loaded with Dexamethasone for Soft Tissue Applications. Pharmaceutics. 2023;15(10):2478 [Crossref]
13- Taghe S, Mirzaeei S, Hosseinkhani T. Design and development of dual drug-loaded nanofibrous inserts for ophthalmic sustained delivery of AMK and VAN: Pharmacokinetic study in rabbit’s eye. International Journal of Pharmaceutics. 2024;656:124056 [Crossref]
14- Taghe S, Mirzaeei S, Pakdaman N, Kazemi A, Nokhodchi A. Macrolide-loaded nanofibrous inserts with polycaprolactone and cellulose acetate base for sustained ocular delivery: Pharmacokinetic study in Rabbit’s eye. International Journal of Pharmaceutics. 2024;665:124699 [Crossref]
15- Chiang M, Chern E. More than Antibiotics: Latest Therapeutics in the Treatment and Prevention of Ocular Surface Infections. JCM. 2022;11(14):4195 [Crossref]