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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2022;12(4): 658-672. doi: 10.34172/apb.2022.070
PMID: 36415646        PMCID: PMC9675923

Review Article

Electrospun Polycaprolactone Nanofibers: Current Research and Applications in Biomedical Application

Arezo Azari 1 ORCID, Ali Golchin 2,3 * ORCID, Maryam Mahmoodinia Maymand 4 ORCID, Fatemeh Mansouri 5,6 ORCID, Abdolreza Ardeshirylajimi 7,8 ORCID

Cited by CrossRef: 16

1- Taghizadeh F, Heidari M, Mostafavi S, Mortazavi S, Haeri A. A review of preparation methods and biomedical applications of poly(ε-caprolactone)-based novel formulations. J Mater Sci. 2024;59(24):10587 [Crossref]
2- Başbuğ B, Beycan B, Erdoğan M, Karakışla M, Saçak M. Exploring Waste Wool Derived-Keratin Nanofiber Architectures on Cotton Fabrics: Electrospinning Strategies for Enhanced Material Properties. ACS Appl Polym Mater. 2024;6(13):7417 [Crossref]
3- Rahnama M, Ghasemzadeh N, Ebrahimi Y, Golchin A. A comprehensive evaluation of dermal fibroblast therapy in clinical trials for treating skin disorders and cosmetic applications: a scoping review. Stem Cell Res Ther. 2024;15(1) [Crossref]
4- Wani T, Khan R, Rather A, Rafiq M, Majeed S, Khan H, Sheikh F. Novel Bioactive Multi-layered Nanofibers Composed of poly(ɛ-caprolactone) and Poly(Vinyl Alcohol) Loaded with Zoledronic Acid and Silver Nanoparticles. BioNanoSci. 2025;15(2) [Crossref]
5- Yekrang J, Yousefi A. Co-electrospun (polyvinyl alcohol/ Lepidium perfoliatum seed gum)-polycaprolactone hybrid nanofibers for antibacterial wound dressing applications . International Journal of Polymeric Materials and Polymeric Biomaterials. 2024;73(16):1401 [Crossref]
6- ELhabal S, El-Nabarawi M, Hassanin S, Hassan F, Abbas S, Gebril S, Albash R. Transdermal fluocinolone acetonide loaded decorated hyalurosomes cellulose acetate/polycaprolactone nanofibers mitigated Freund’s adjuvant-induced rheumatoid arthritis in rats. J Pharm Investig. 2025;55(1):113 [Crossref]
7- Karimi shayan T, Asadi A, Abdolmaleki A, Hassanpour H. The Neuroprotective Effects of Nano-Scaffolds Enriched with Piracetam and Octreotide Drugs on Neural Cells Following Oxidative Stress. Shefaye Khatam. 2024;12(2):1 [Crossref]
8- Yang M, Cheng Q, Zhou G, Wei T, Zhong S, Lu L, Yan C, Wang Y, Fang M, Yang M, Ping W. Electrospinning Aligned SF/Magnetic Nanoparticles-Blend Nanofiber Scaffolds for Inducing Skeletal Myoblast Alignment and Differentiation. ACS Appl Bio Mater. 2024;7(11):7710 [Crossref]
9- Geysoğlu M, Cengiz Çallıoğlu F. Electrospinning of protein based egg albumin nanofibers. The Journal of The Textile Institute. 2025;116(3):399 [Crossref]
10- Singh E, Osmani R, Banerjee R, Abu Lila A, Moin A, Almansour K, Arab H, Alotaibi H, Khafagy E. Poly ε-Caprolactone Nanoparticles for Sustained Intra-Articular Immune Modulation in Adjuvant-Induced Arthritis Rodent Model. Pharmaceutics. 2022;14(3):519 [Crossref]
11- Phuong H, Thu D, Liem N, Doan V. Stable Fabrication of Chitosan/Polycaprolactone (CS/PCL) Core-Shell Nanofibers by Electrospinning. MSF. 2024;1139:107 [Crossref]
12- Onesto V, Forciniti S, Alemanno F, Narayanankutty K, Chandra A, Prasad S, Azzariti A, Gigli G, Barra A, De Martino A, De Martino D, del Mercato L. Probing Single-Cell Fermentation Fluxes and Exchange Networks via pH-Sensing Hybrid Nanofibers. ACS Nano. 2023;17(4):3313 [Crossref]
13- Kim D, Yi S, Park B, Eom S, Kang S, Kim D, Kim H. Light-Blocking Nanofiber Membranes Facilitating Physiologically Relevant In Situ Transmigration Assay. ACS Biomater Sci Eng. 2025;11(3):1834 [Crossref]
14- Dachani S, Vashi A, Mundada A, Mundada P, Rudrangi S, Rudrangi S, Tiwari R. “Innovative Polymers in Pharmaceutical Chemistry: Revolutionizing Drug Delivery Systems”. Polymer-Plastics Technology and Materials. 2024;:1 [Crossref]
15- Sali A, Duzyer Gebizli S, Goktalay G. Silymarin-loaded electrospun polycaprolactone nanofibers as wound dressing. Journal of Materials Research. 2023;38(8):2251 [Crossref]
16- Chaka K, Cao K, Tesfaye T, Qin X. Nanomaterial-functionalized electrospun scaffolds for tissue engineering. Journal of Biomaterials Science, Polymer Edition. 2025;36(3):371 [Crossref]
17- Goshtasbi N, Mehryab F, Mortazavi S, Ghorbani R, Haeri A. Fabrication, Physicochemical Characterization, and in Silico Evaluation of Bilayer Nanofibers as a Potential Sustained Crocin Delivery Dressing. J Pharm Innov. 2024;19(3) [Crossref]
18- An J, Ma T, Wang Q, Zhang J, Santerre J, Wang W, Ma P, Zhang X. Defining optimal electrospun membranes to enhance biological activities of human endometrial MSCs. Front Bioeng Biotechnol. 2025;13 [Crossref]
19- Kaliaperumal C, Thulasisingh A. Electrospun polycaprolactone/chitosan/pectin composite nanofibre: a novel wound dressing scaffold. Bull Mater Sci. 2023;46(1) [Crossref]
20- Arunachalam S, Dixit H, Samavedi S. Establishment of Unique Cone Shapes and Universal Shape Parameters toward Predicting Fiber Diameter in Polymer Electrospinning. Ind Eng Chem Res. 2024;63(30):13238 [Crossref]
21- Nazemoroaia M, Bagheri F, Mirahmadi-Zare S, Eslami-kaliji F, Derakhshan A. Asymmetric natural wound dressing based on porous chitosan-alginate hydrogel/electrospun PCL-silk sericin loaded by 10-HDA for skin wound healing: In vitro and in vivo studies. International Journal of Pharmaceutics. 2025;668:124976 [Crossref]