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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2022;12(4): 658-672. doi: 10.34172/apb.2022.070
PMID: 36415646        PMCID: PMC9675923

Review Article

Electrospun Polycaprolactone Nanofibers: Current Research and Applications in Biomedical Application

Arezo Azari 1 ORCID, Ali Golchin 2,3 * ORCID, Maryam Mahmoodinia Maymand 4 ORCID, Fatemeh Mansouri 5,6 ORCID, Abdolreza Ardeshirylajimi 7,8 ORCID

Cited by CrossRef: 16

1- Taghizadeh F, Heidari M, Mostafavi S, Mortazavi S, Haeri A. A review of preparation methods and biomedical applications of poly(ε-caprolactone)-based novel formulations. J Mater Sci. 2024;59(24):10587 [Crossref]
2- Başbuğ B, Beycan B, Erdoğan M, Karakışla M, Saçak M. Exploring Waste Wool Derived-Keratin Nanofiber Architectures on Cotton Fabrics: Electrospinning Strategies for Enhanced Material Properties. ACS Appl Polym Mater. 2024;6(13):7417 [Crossref]
3- Rahnama M, Ghasemzadeh N, Ebrahimi Y, Golchin A. A comprehensive evaluation of dermal fibroblast therapy in clinical trials for treating skin disorders and cosmetic applications: a scoping review. Stem Cell Res Ther. 2024;15(1) [Crossref]
4- Wani T, Khan R, Rather A, Rafiq M, Majeed S, Khan H, Sheikh F. Novel Bioactive Multi-layered Nanofibers Composed of poly(ɛ-caprolactone) and Poly(Vinyl Alcohol) Loaded with Zoledronic Acid and Silver Nanoparticles. BioNanoSci. 2025;15(2) [Crossref]
5- Yekrang J, Yousefi A. Co-electrospun (polyvinyl alcohol/ Lepidium perfoliatum seed gum)-polycaprolactone hybrid nanofibers for antibacterial wound dressing applications . International Journal of Polymeric Materials and Polymeric Biomaterials. 2024;73(16):1401 [Crossref]
6- ELhabal S, El-Nabarawi M, Hassanin S, Hassan F, Abbas S, Gebril S, Albash R. Transdermal fluocinolone acetonide loaded decorated hyalurosomes cellulose acetate/polycaprolactone nanofibers mitigated Freund’s adjuvant-induced rheumatoid arthritis in rats. J Pharm Investig. 2025;55(1):113 [Crossref]
7- Karimi shayan T, Asadi A, Abdolmaleki A, Hassanpour H. The Neuroprotective Effects of Nano-Scaffolds Enriched with Piracetam and Octreotide Drugs on Neural Cells Following Oxidative Stress. Shefaye Khatam. 2024;12(2):1 [Crossref]
8- Yang M, Cheng Q, Zhou G, Wei T, Zhong S, Lu L, Yan C, Wang Y, Fang M, Yang M, Ping W. Electrospinning Aligned SF/Magnetic Nanoparticles-Blend Nanofiber Scaffolds for Inducing Skeletal Myoblast Alignment and Differentiation. ACS Appl Bio Mater. 2024;7(11):7710 [Crossref]
9- Geysoğlu M, Cengiz Çallıoğlu F. Electrospinning of protein based egg albumin nanofibers. The Journal of The Textile Institute. 2025;116(3):399 [Crossref]
10- Singh E, Osmani R, Banerjee R, Abu Lila A, Moin A, Almansour K, Arab H, Alotaibi H, Khafagy E. Poly ε-Caprolactone Nanoparticles for Sustained Intra-Articular Immune Modulation in Adjuvant-Induced Arthritis Rodent Model. Pharmaceutics. 2022;14(3):519 [Crossref]
11- Phuong H, Thu D, Liem N, Doan V. Stable Fabrication of Chitosan/Polycaprolactone (CS/PCL) Core-Shell Nanofibers by Electrospinning. MSF. 2024;1139:107 [Crossref]
12- Onesto V, Forciniti S, Alemanno F, Narayanankutty K, Chandra A, Prasad S, Azzariti A, Gigli G, Barra A, De Martino A, De Martino D, del Mercato L. Probing Single-Cell Fermentation Fluxes and Exchange Networks via pH-Sensing Hybrid Nanofibers. ACS Nano. 2023;17(4):3313 [Crossref]
13- Kim D, Yi S, Park B, Eom S, Kang S, Kim D, Kim H. Light-Blocking Nanofiber Membranes Facilitating Physiologically Relevant In Situ Transmigration Assay. ACS Biomater Sci Eng. 2025;11(3):1834 [Crossref]
14- Dachani S, Vashi A, Mundada A, Mundada P, Rudrangi S, Rudrangi S, Tiwari R. “Innovative Polymers in Pharmaceutical Chemistry: Revolutionizing Drug Delivery Systems”. Polymer-Plastics Technology and Materials. 2025;64(7):911 [Crossref]
15- Sali A, Duzyer Gebizli S, Goktalay G. Silymarin-loaded electrospun polycaprolactone nanofibers as wound dressing. Journal of Materials Research. 2023;38(8):2251 [Crossref]
16- Chaka K, Cao K, Tesfaye T, Qin X. Nanomaterial-functionalized electrospun scaffolds for tissue engineering. Journal of Biomaterials Science, Polymer Edition. 2025;36(3):371 [Crossref]
17- Konain K, Farid S, Hameed S, Rehman F, Samie M, Sharif F, Zaman M, Habib S, Elango J, Rahman S. Arabinoxylan-Incorporated Poly(ε-caprolactone) Nanofiber Matrix Promote Fibroblast Cells Adhesion and Proliferation. BioNanoSci. 2025;15(2) [Crossref]
18- Goshtasbi N, Mehryab F, Mortazavi S, Ghorbani R, Haeri A. Fabrication, Physicochemical Characterization, and in Silico Evaluation of Bilayer Nanofibers as a Potential Sustained Crocin Delivery Dressing. J Pharm Innov. 2024;19(3) [Crossref]
19- Ikhtiarini N, Kamil M, Bukit B, Juliadmi D, Prasetiyo K, Fransiska D, Sedayu B, Subiyanto B, Sulastiningsih I, Rochima E, Arivendan A, Syamani F. Biocompatible composites based on alginate, polycaprolactone, and nanocellulose - A review. International Journal of Biological Macromolecules. 2025;:143423 [Crossref]
20- An J, Ma T, Wang Q, Zhang J, Santerre J, Wang W, Ma P, Zhang X. Defining optimal electrospun membranes to enhance biological activities of human endometrial MSCs. Front Bioeng Biotechnol. 2025;13 [Crossref]
21- Kaliaperumal C, Thulasisingh A. Electrospun polycaprolactone/chitosan/pectin composite nanofibre: a novel wound dressing scaffold. Bull Mater Sci. 2023;46(1) [Crossref]
22- Arunachalam S, Dixit H, Samavedi S. Establishment of Unique Cone Shapes and Universal Shape Parameters toward Predicting Fiber Diameter in Polymer Electrospinning. Ind Eng Chem Res. 2024;63(30):13238 [Crossref]
23- Nazemoroaia M, Bagheri F, Mirahmadi-Zare S, Eslami-kaliji F, Derakhshan A. Asymmetric natural wound dressing based on porous chitosan-alginate hydrogel/electrospun PCL-silk sericin loaded by 10-HDA for skin wound healing: In vitro and in vivo studies. International Journal of Pharmaceutics. 2025;668:124976 [Crossref]