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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2023;13(2): 317-327. doi: 10.34172/apb.2023.035
PMID: 37342377        PMCID: PMC10278223

Research Article

In Vitro Efficacy of Curcumin-Loaded Amine-Functionalized Mesoporous Silica Nanoparticles against MCF-7 Breast Cancer Cells

Zahra Mohebian 1, Mirzaagha Babazadeh 1, Nosratollah Zarghami 2 * ORCID

Cited by CrossRef: 6

1- Ochoa-Sanchez A, Sahare P, Pathak S, Banerjee A, Estevez M, Duttaroy A, Luna-Bárcenas G, Paul S. Evaluation of the synergistic effects of curcumin-resveratrol co-loaded biogenic silica on colorectal cancer cells. Front Pharmacol. 2024;15 [Crossref]
2- Aykaç A, Ok İ, Bakay E, Topaloğlu N. Chitosan-based hydrogel incorporating mesoporous silica/zinc oxide nanoparticles with controlled swelling and potent antibacterial activity. International Journal of Polymeric Materials and Polymeric Biomaterials. 2025;74(6):465 [Crossref]
3- Vieira I, Tessaro L, Lima A, Velloso I, Conte-Junior C. Recent Progress in Nanotechnology Improving the Therapeutic Potential of Polyphenols for Cancer. Nutrients. 2023;15(14):3136 [Crossref]
4- Zhao Y, Xue Y, Wang C, Zhao Z, Cui R, Zhu B. Antibacterial poly(ethyl methacrylate) surfaces constructed by facile amination with polyethyleneimine of different architectures. Colloids and Surfaces B: Biointerfaces. 2025;248:114458 [Crossref]
5- Alallam B, Abdkadir E, Hayati A, Keong Y, Lim V. Alginate coated mesoporous silica nanoparticles as oral delivery carrier of curcumin and quercetin to colon cancer: preparation, optimization, characterization, and anticancer activity. Drug Deliv and Transl Res. 2025; [Crossref]
6- Rahman M, Afzal O, Ullah S, Alshahrani M, Alkhathami A, Altamimi A, Almujri S, Almalki W, Shorog E, Alossaimi M, Mandal A, abdulrahman A, Sahoo A. Nanomedicine-Based Drug-Targeting in Breast Cancer: Pharmacokinetics, Clinical Progress, and Challenges. ACS Omega. 2023;8(51):48625 [Crossref]
7- Sivasankaran L, Rahim S, Sreenivasan A. Synthesis and Anticancer Activity Evaluation of Self- assembled Curcumin Loaded Gelatin − Oleic acid – Carboxymethyl Chitosan Nanoparticles on MCF-7 cells. European Journal of Pharmaceutics and Biopharmaceutics. 2025;211:114718 [Crossref]
8- Sharma G, Panwar R, Saini S, Tuli H, Wadhwa K, Pahwa R. Emerging phytochemical-based nanocarriers: redefining the perspectives of breast cancer therapy. Naunyn-Schmiedeberg's Arch Pharmacol. 2025; [Crossref]
9- Rostami N, Ghebleh A, Noei H, Rizi Z, Moeinzadeh A, Nikzad A, Gomari M, Uversky V, Tarighi P. Peptide-functionalized polymeric nanoparticles for delivery of curcumin to cancer cells. Journal of Drug Delivery Science and Technology. 2024;102:106337 [Crossref]
10- Guan C, Han Y, Ling Z, Meng X, Zhang B, Dong W, Zhang D, Chen K. Nanomaterials: breaking the bottleneck of breast cancer drug resistance. Front Immunol. 2024;15 [Crossref]
11- Ahmed K, Ahmad U, Akhtar J, Islam A, Khan M, Khan B. Mesoporous silica nanoparticles in skin cancer therapy: Multifaceted approaches in drug delivery. Journal of Drug Delivery Science and Technology. 2025;109:107021 [Crossref]
12- Nishal S, Kumar V, Phaugat P, Kumar D, Khatri N, Singh G. A Systematic Review and Meta-Analysis of the Metal Nano-Particles Loaded with Herbal Drugs Moieties Against Breast Cancer. NANOTEC. 2025;19(1):120 [Crossref]
13- Esmaeli M, Ghanbari A, Dehghanpour Dehabadi M, Nazri P, Parsayee Manesh E, Khaleghi A. Investigating the Anti-tumor Mechanisms of Curcumin on Various Breast Cancer Cell Lines: A Systematic Review. Indian J Gynecol Oncolog. 2025;23(1) [Crossref]