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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2023;13(2): 317-327. doi: 10.34172/apb.2023.035
PMID: 37342377        PMCID: PMC10278223

Research Article

In Vitro Efficacy of Curcumin-Loaded Amine-Functionalized Mesoporous Silica Nanoparticles against MCF-7 Breast Cancer Cells

Zahra Mohebian 1, Mirzaagha Babazadeh 1, Nosratollah Zarghami 2 * ORCID

Cited by CrossRef: 6

1- Ochoa-Sanchez A, Sahare P, Pathak S, Banerjee A, Estevez M, Duttaroy A, Luna-Bárcenas G, Paul S. Evaluation of the synergistic effects of curcumin-resveratrol co-loaded biogenic silica on colorectal cancer cells. Front Pharmacol. 2024;15 [Crossref]
2- Aykaç A, Ok İ, Bakay E, Topaloğlu N. Chitosan-based hydrogel incorporating mesoporous silica/zinc oxide nanoparticles with controlled swelling and potent antibacterial activity. International Journal of Polymeric Materials and Polymeric Biomaterials. 2025;74(6):465 [Crossref]
3- Nasiri M, Anani Sarab G, Sayadi M, Shakibaie M. Effects of curcumin-loaded amine-functionalized mesoporous silica nanoparticles on apoptosis induction and cell cycle arrest in RPMI-8226 multiple myeloma cell line. J Birjand Univ Med Sci. 2025;32(2):98 [Crossref]
4- Vieira I, Tessaro L, Lima A, Velloso I, Conte-Junior C. Recent Progress in Nanotechnology Improving the Therapeutic Potential of Polyphenols for Cancer. Nutrients. 2023;15(14):3136 [Crossref]
5- Zhao Y, Xue Y, Wang C, Zhao Z, Cui R, Zhu B. Antibacterial poly(ethyl methacrylate) surfaces constructed by facile amination with polyethyleneimine of different architectures. Colloids and Surfaces B: Biointerfaces. 2025;248:114458 [Crossref]
6- Akter K, Gul K, Mumtaz S. Revisiting Curcumin in Cancer Therapy: Recent Insights into Molecular Mechanisms, Nanoformulations, and Synergistic Combinations. CIMB. 2025;47(9):716 [Crossref]
7- Fu Y, Ge Y, Yi S, Peng Q, Jiang H, Zhou J. Smart nanoparticle delivery systems for curcumin: a targeted strategy to enhance anticancer efficacy and bioavailability. J Mater Sci: Mater Med. 2026;37(1) [Crossref]
8- Alallam B, Abdkadir E, Hayati A, Keong Y, Lim V. Alginate coated mesoporous silica nanoparticles as oral delivery carrier of curcumin and quercetin to colon cancer: preparation, optimization, characterization, and anticancer activity. Drug Deliv and Transl Res. 2025;15(11):3793 [Crossref]
9- Rahman M, Afzal O, Ullah S, Alshahrani M, Alkhathami A, Altamimi A, Almujri S, Almalki W, Shorog E, Alossaimi M, Mandal A, abdulrahman A, Sahoo A. Nanomedicine-Based Drug-Targeting in Breast Cancer: Pharmacokinetics, Clinical Progress, and Challenges. ACS Omega. 2023;8(51):48625 [Crossref]
10- Sivasankaran L, Rahim S, Sreenivasan A. Synthesis and Anticancer Activity Evaluation of Self- assembled Curcumin Loaded Gelatin − Oleic acid – Carboxymethyl Chitosan Nanoparticles on MCF-7 cells. European Journal of Pharmaceutics and Biopharmaceutics. 2025;211:114718 [Crossref]
11- Akhtari N, Sheykholeslami S, Sablagh Y, Mohammadgholi A, Mansouri A, Abbasi H, Noorbazargan H. Mesoporous Silica Nanoparticles Modified with Zinc, Amine, and Graphene Oxide for Controlled Doxorubicin Delivery in Breast Cancer Therapy. J Pharm Innov. 2026;21(5) [Crossref]
12- Sharma G, Panwar R, Saini S, Tuli H, Wadhwa K, Pahwa R. Emerging phytochemical-based nanocarriers: redefining the perspectives of breast cancer therapy. Naunyn-Schmiedeberg's Arch Pharmacol. 2025;398(9):11199 [Crossref]
13- Rostami N, Ghebleh A, Noei H, Rizi Z, Moeinzadeh A, Nikzad A, Gomari M, Uversky V, Tarighi P. Peptide-functionalized polymeric nanoparticles for delivery of curcumin to cancer cells. Journal of Drug Delivery Science and Technology. 2024;102:106337 [Crossref]
14- Guan C, Han Y, Ling Z, Meng X, Zhang B, Dong W, Zhang D, Chen K. Nanomaterials: breaking the bottleneck of breast cancer drug resistance. Front Immunol. 2024;15 [Crossref]
15- Ahmed K, Ahmad U, Akhtar J, Islam A, Khan M, Khan B. Mesoporous silica nanoparticles in skin cancer therapy: Multifaceted approaches in drug delivery. Journal of Drug Delivery Science and Technology. 2025;109:107021 [Crossref]
16- Siddheshwar S, Jejurkar S, Ghorpade A, Mankar S. Development and optimization of tivozanib loaded amine functionalized mesoporous silica nanoparticles for enhanced drug delivery. Next Nanotechnology. 2026;9:100402 [Crossref]
17- Firouzpour H, Najafi F, Mohammadgholi A, Alizadegan D, Mahmoudi Beram F, Akhtari N, Zoghi M, Ansar N, Tavakkoli Yaraki M. Nanoparticle-based drug delivery systems for effective cancer treatment: Mechanisms and applications. Next Nanotechnology. 2026;9:100372 [Crossref]
18- Nishal S, Kumar V, Phaugat P, Kumar D, Khatri N, Singh G. A Systematic Review and Meta-Analysis of the Metal Nano-Particles Loaded with Herbal Drugs Moieties Against Breast Cancer. NANOTEC. 2025;19(1):120 [Crossref]
19- Esmaeli M, Ghanbari A, Dehghanpour Dehabadi M, Nazri P, Parsayee Manesh E, Khaleghi A. Investigating the Anti-tumor Mechanisms of Curcumin on Various Breast Cancer Cell Lines: A Systematic Review. Indian J Gynecol Oncolog. 2025;23(1) [Crossref]
20- Arteaga-Castrejón A, Díaz-Rodríguez T, Celaya C, Antúnez E, Muñiz J, Khandual S, Agarwal V. Understanding the enhanced thermal stability of astaxanthin loaded onto functionalized biogenic porous silica: Experimental and theoretical approach. Surfaces and Interfaces. 2026;80:108360 [Crossref]