Logo-apb

Journal Info:

Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

Permission: CC By

Platinum Open Access

(no submission or publication fees)

Powered by
Adv Pharm Bull. 2023;13(2): 275-282. doi: 10.34172/apb.2023.030
PMID: 37342385        PMCID: PMC10278227

Mini Review

Chitosan and Its Structural Modifications for siRNA Delivery

Mona Y. Al-Absi 1 ORCID, Anna Eleonora Caprifico 1 ORCID, Gianpiero Calabrese 1 * ORCID

Cited by CrossRef: 8

1- Li Z, Hu Z, Gao Z. Advances in the Study of Age-Related Macular Degeneration Based on Cell or Cell-Biomaterial Scaffolds. Bioengineering. 2025;12(3):278 [Crossref]
2- Spencer A, Vilaça A, Xavier M, Santos R, Ionescu A, Lázaro M, Leiro V, Perlson E, Guimarães S, Maoz B, Pêgo A. Engineered Chitosan‐Derived Nanocarrier for Efficient siRNA Delivery to Peripheral and Central Neurons. Adv Healthcare Materials. 2025;14(15) [Crossref]
3- Mokhles F, Gonzalez-Valdivieso J, Moosavi M, Cordani M. Advances in nanoparticle-mediated transdermal delivery of nucleic acids as therapy of skin disorders and cancer. Current Opinion in Biomedical Engineering. 2025;35:100611 [Crossref]
4- Singh P, Singh M, Singh B, Sharma K, Kumar N, Singh D, Klair H, Mastana S. Implications of siRNA Therapy in Bone Health: Silencing Communicates. Biomedicines. 2024;12(1):90 [Crossref]
5- Wang Z, Pang S, Liu X, Dong Z, Tian Y, Ashrafizadeh M, Rabiee N, Ertas Y, Mao Y. Chitosan- and hyaluronic acid-based nanoarchitectures in phototherapy: Combination cancer chemotherapy, immunotherapy and gene therapy. International Journal of Biological Macromolecules. 2024;273:132579 [Crossref]
6- Joshi R, Paliwal T, Sharma S, Kapoor D, Prajapati B. Chitosan polyplexes for targeted gene delivery: From mechanisms to clinical applications. Carbohydrate Polymers. 2025;368:124080 [Crossref]
7- Wang W, Wang N, Zhao X, Su X, Liu Z. Recent advancements in polymer science for retinal diseases: New frontiers in drug delivery systems. 2025;9(2) [Crossref]
8- Karayianni M, Sentoukas T, Skandalis A, Pippa N, Pispas S. Chitosan-Based Nanoparticles for Nucleic Acid Delivery: Technological Aspects, Applications, and Future Perspectives. Pharmaceutics. 2023;15(7):1849 [Crossref]
9- Karimi S, Namazi H, Aghazadeh M. Simultaneous Release of Hydrophilic and Hydrophobic Drugs by a pH-sensitive Bio-carrier Based on Layered Double Hydroxides Decorated with l-serine-chitosan. J Polym Environ. 2025;33(6):2758 [Crossref]
10- Naghib S, Ahmadi B, Mozafari M. Smart Physicochemical-triggered Chitosan-based Nanogels for siRNA Delivery and Gene Therapy: A Focus on Emerging Strategies and Paradigms for Cancer Therapy. CMC. 2025;32(24):4913 [Crossref]
11- Antoniou V, Mourelatou E, Galatou E, Avgoustakis K, Hatziantoniou S. Gene Therapy with Chitosan Nanoparticles: Modern Formulation Strategies for Enhancing Cancer Cell Transfection. Pharmaceutics. 2024;16(7):868 [Crossref]
12- Redhwan M, M.G. H, Samaddar S, Bafail D, Hard S, Guha S. Chitosan/siRNA nanoparticles targeting PARP-1 attenuate Neuroinflammation and apoptosis in hyperglycemia-induced oxidative stress in Neuro2a cells. International Journal of Biological Macromolecules. 2024;282:136964 [Crossref]
13- Kögel D, Temme A, Aigner A. Recent advances in development and delivery of non-viral nucleic acid therapeutics for brain tumor therapy. Pharmacology & Therapeutics. 2025;266:108762 [Crossref]
14- Forenzo C, Arnold N, Larsen J. Emerging polymeric nanocarriers for mRNA and protein therapeutics: design, challenges, and clinical outlook. Nanomedicine. 2025;:1 [Crossref]
15- Yao Z, Liu T, Wang J, Fu Y, Zhao J, Wang X, Li Y, Yang X, He Z. Targeted delivery systems of siRNA based on ionizable lipid nanoparticles and cationic polymer vectors. Biotechnology Advances. 2025;81:108546 [Crossref]
16- Regev A, Benafsha C, Goldbart R, Traitel T, Elkabets M, Kost J. Effect of Degree of Substitution and Molecular Weight on Transfection Efficacy of Starch-Based siRNA Delivery System. Polysaccharides. 2024;5(4):580 [Crossref]