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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2023;13(2): 275-282. doi: 10.34172/apb.2023.030
PMID: 37342385        PMCID: PMC10278227

Mini Review

Chitosan and Its Structural Modifications for siRNA Delivery

Mona Y. Al-Absi 1 ORCID, Anna Eleonora Caprifico 1 ORCID, Gianpiero Calabrese 1 * ORCID

Cited by CrossRef: 8

1- Pozdniakova N, Generalov E, Shevelev A, Tarasova O. RNA Therapeutics: Delivery Problems and Solutions—A Review. Pharmaceutics. 2025;17(10):1305 [Crossref]
2- Martinez Junior A, de Oliveira Tiera V, Tiera M. O-substituted Tertiary Amine-chitosans as Promising Nanocarriers for siRNA Delivery. CGT. 2025;25(5):729 [Crossref]
3- Mokhles F, Gonzalez-Valdivieso J, Moosavi M, Cordani M. Advances in nanoparticle-mediated transdermal delivery of nucleic acids as therapy of skin disorders and cancer. Current Opinion in Biomedical Engineering. 2025;35:100611 [Crossref]
4- He J, Jin Z, Guo F, Li Y, Zeng D, Tu Y, Liu H, Liu L. Traceable pH/near-infrared dual-responsive chitosan quantum dots/polypyrrole nanocarrier for efficient and controllable DNA delivery. International Journal of Biological Macromolecules. 2025;328:147693 [Crossref]
5- Joshi R, Paliwal T, Sharma S, Kapoor D, Prajapati B. Chitosan polyplexes for targeted gene delivery: From mechanisms to clinical applications. Carbohydrate Polymers. 2025;368:124080 [Crossref]
6- Kar N, Lin J, HassankhaniRad A, Li W, Aboushanab A, Li Y, Sun J. Smart polymeric nanoparticles for targeted delivery and microenvironment-responsive therapy in pancreatic cancer. Smart Materials in Medicine. 2025;6(3):368 [Crossref]
7- Wang W, Wang N, Zhao X, Su X, Liu Z. Recent advancements in polymer science for retinal diseases: New frontiers in drug delivery systems. 2025;9(2) [Crossref]
8- Karimi S, Namazi H, Aghazadeh M. Simultaneous Release of Hydrophilic and Hydrophobic Drugs by a pH-sensitive Bio-carrier Based on Layered Double Hydroxides Decorated with l-serine-chitosan. J Polym Environ. 2025;33(6):2758 [Crossref]
9- Naghib S, Ahmadi B, Mozafari M. Smart Physicochemical-triggered Chitosan-based Nanogels for siRNA Delivery and Gene Therapy: A Focus on Emerging Strategies and Paradigms for Cancer Therapy. CMC. 2025;32(24):4913 [Crossref]
10- Irfan M, Sagheer H, Elahi M. Integrating Green Nanomaterials and RNA Interference: A Combinatorial Approach for Breast Cancer Treatment. Regen Eng Transl Med. 2025; [Crossref]
11- Yao Z, Liu T, Wang J, Fu Y, Zhao J, Wang X, Li Y, Yang X, He Z. Targeted delivery systems of siRNA based on ionizable lipid nanoparticles and cationic polymer vectors. Biotechnology Advances. 2025;81:108546 [Crossref]
12- Regev A, Benafsha C, Goldbart R, Traitel T, Elkabets M, Kost J. Effect of Degree of Substitution and Molecular Weight on Transfection Efficacy of Starch-Based siRNA Delivery System. Polysaccharides. 2024;5(4):580 [Crossref]
13- Li Z, Hu Z, Gao Z. Advances in the Study of Age-Related Macular Degeneration Based on Cell or Cell-Biomaterial Scaffolds. Bioengineering. 2025;12(3):278 [Crossref]
14- Spencer A, Vilaça A, Xavier M, Santos R, Ionescu A, Lázaro M, Leiro V, Perlson E, Guimarães S, Maoz B, Pêgo A. Engineered Chitosan‐Derived Nanocarrier for Efficient siRNA Delivery to Peripheral and Central Neurons. Adv Healthcare Materials. 2025;14(15) [Crossref]
15- Singh P, Singh M, Singh B, Sharma K, Kumar N, Singh D, Klair H, Mastana S. Implications of siRNA Therapy in Bone Health: Silencing Communicates. Biomedicines. 2024;12(1):90 [Crossref]
16- Aranda-Lara L, Escudero-Castellanos A, Trujillo-Nolasco M, Morales-Avila E, Ocampo-García B, Oros-Pantoja R, Sánchez-Monroy V, Isaac-Olivé K. Small Interfering RNA Carriers for Oncotherapy: A Preclinical Overview. Pharmaceutics. 2025;17(11):1408 [Crossref]
17- Jian Y, Zheng Q, Hu S, Jian Y. siRNA nanodelivery systems in the treatment of skin Diseases: Research progress and clinical translation prospects. European Journal of Pharmacology. 2025;1005:178075 [Crossref]
18- Wang Z, Pang S, Liu X, Dong Z, Tian Y, Ashrafizadeh M, Rabiee N, Ertas Y, Mao Y. Chitosan- and hyaluronic acid-based nanoarchitectures in phototherapy: Combination cancer chemotherapy, immunotherapy and gene therapy. International Journal of Biological Macromolecules. 2024;273:132579 [Crossref]
19- Karayianni M, Sentoukas T, Skandalis A, Pippa N, Pispas S. Chitosan-Based Nanoparticles for Nucleic Acid Delivery: Technological Aspects, Applications, and Future Perspectives. Pharmaceutics. 2023;15(7):1849 [Crossref]
20- Antoniou V, Mourelatou E, Galatou E, Avgoustakis K, Hatziantoniou S. Gene Therapy with Chitosan Nanoparticles: Modern Formulation Strategies for Enhancing Cancer Cell Transfection. Pharmaceutics. 2024;16(7):868 [Crossref]
21- Redhwan M, M.G. H, Samaddar S, Bafail D, Hard S, Guha S. Chitosan/siRNA nanoparticles targeting PARP-1 attenuate Neuroinflammation and apoptosis in hyperglycemia-induced oxidative stress in Neuro2a cells. International Journal of Biological Macromolecules. 2024;282:136964 [Crossref]
22- Kögel D, Temme A, Aigner A. Recent advances in development and delivery of non-viral nucleic acid therapeutics for brain tumor therapy. Pharmacology & Therapeutics. 2025;266:108762 [Crossref]
23- Forenzo C, Arnold N, Larsen J. Emerging polymeric nanocarriers for mRNA and protein therapeutics: design, challenges, and clinical outlook. Nanomedicine. 2025;20(18):2357 [Crossref]