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Adv Pharm Bull. 2023;13(4): 747-760. doi: 10.34172/apb.2023.077
PMID: 38022805        PMCID: PMC10676553

Research Article

Targeted Delivery of Pennyroyal via Methotrexate Functionalized PEGylated Nanostructured Lipid Carriers into Breast Cancer Cells; A Multiple Pathways Apoptosis Activator

Amin Mahoutforoush 1,2,3 ORCID, Leila Asadollahi 2 ORCID, Hamed Hamishehkar 2 * ORCID, Soheil Abbaspour-Ravasjani 2 * ORCID, Atefeh Solouk 3 ORCID, Masoumeh Haghbin Nazarpak 4 ORCID

Cited by CrossRef: 6


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4- Vosoughi P, Naghib S, Jafari T, Kangarshahi B. Chitosan-encapsulated lipid-based nanovesicles for therapeutic applications and tissue engineering: A review. Carbohydrate Polymer Technologies and Applications. 2025;10:100805 [Crossref]
5- Farheen J, Iqbal M, Lu Y, Tang Z, Kong X. Vitis vinifera Kyoho-derived exosome-like nanoparticles-based drug delivery and therapeutic modalities for breast cancer therapy. Journal of Drug Delivery Science and Technology. 2024;92:105332 [Crossref]
6- Naseem N, Kushwaha P, Haider F. Leveraging nanostructured lipid carriers to enhance targeted delivery and efficacy in breast cancer therapy: a comprehensive review. Naunyn-Schmiedeberg's Arch Pharmacol. 2025;398(1):449 [Crossref]
7- Nam S, Bharti D, Seong H, Kim Y, Jeong C, Yang K. Nanoemulsification of epigallocatechin gallate for debitterization, antibrowning, and inhibition of intracellular lipid accumulation. Food Bioscience. 2024;61:104792 [Crossref]
8- Medina-Magariño E, Pinos-Rodríguez J, Pulido-Capiz Á, García-González V, Torres-Maravilla E, Quiroz-Mercado J, Cano-Sarmiento C. Anti-proliferative and Pro-apoptotic Activity of a Novel Oil-in-Water Nanoemulsion Containing Tea Tree Oil, Quercetin, and Rosmarinic Acid in Breast Cancer Cells. BioNanoSci. 2025;15(1) [Crossref]
9- Rani S, Gupta S, Tejavath K, Gupta U. Effect of combination of polyphenols, polysaccharide, and sodium selenite on bortezomib anti-cancer action. International Journal of Biological Macromolecules. 2025;289:138809 [Crossref]
10- Bostiog D, Simionescu N, Coroaba A, Marinas I, Chifiriuc M, Gradisteanu Pircalabioru G, Maier S, Pinteala M. Multi-shell gold nanoparticles functionalized with methotrexate: a novel nanotherapeutic approach for improved antitumoral and antioxidant activity and enhanced biocompatibility. Drug Delivery. 2024;31(1) [Crossref]
11- Khateeb S, Hassan A. Insights into nanostructured lipid carriers of etoricoxib for mitigating radiation‐induced lung inflammation and exploring anti‐inflammatory mechanisms in rats. Fundamemntal Clinical Pharma. 2025;39(3) [Crossref]
12- Wu D, Zhou B, Liu Y, Zhu X, Li B, Liang H. Tailoring carrier-free nanoparticles based on natural small molecule assembly for synergistic anti-tumor efficacy. Asian Journal of Pharmaceutical Sciences. 2025;20(1):100992 [Crossref]
13- Zhao Y, Yuan C, Shi Y, Liu X, Luo L, Zhang L, Pešić M, Yao H, Li L. Drug screening approaches for small-molecule compounds in cancer-targeted therapy. Journal of Drug Targeting. 2025;33(3):368 [Crossref]
14- Aththar A, Raushani F, Sekaringtyas F, Muttaqien S, Setyawati D, Pratiwi R, Rifa’i M, Rahmawati S, Putra M, Ahmadi P, Indriani D, Ling J, Widyastuti E, Bayu A, Rosyidah A. Palm oil nanoemulsion enhances tocotrienol stability, antioxidant, and selective anti-melanoma activity. Naunyn-Schmiedeberg's Arch Pharmacol. 2025; [Crossref]