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EBSCOhost; CAS: DOAJ

Adv Pharm Bull. 2023;13(4): 736-746. doi: 10.34172/apb.2023.072

PMID: 38022800 PMCID: PMC10676548

Research Article

17β-Estradiol-Loaded Exosomes for Targeted Drug Delivery in Osteoporosis: A Comparative Study of Two Loading Methods

Mohammad Sadegh Gholami Farashah ^1,2,3,4 , Maryam Javadi ^3,4, Jafar Soleimani Rad ^3,4, Seyed Kazem Shakouri ¹, Solmaz Asnaashari ², Siavoush Dastmalchi ^2,5,6, Sadeneh Nikzad ⁷, Leila Roshangar ^1,3,4 *

Cited by CrossRef: 3

1- Javadi M, Gholami Farashah M, Roshangar L, Soleimani J. Plasma-derived extracellular vesicles improve mice embryo development. Mol Biol Rep. 2024;51(1) [Crossref]

2- Palakurthi S, Shah B, Kapre S, Charbe N, Immanuel S, Pasham S, Thalla M, Jain A, Palakurthi S. A comprehensive review of challenges and advances in exosome-based drug delivery systems. Nanoscale Adv. 2024;6(23):5803 [Crossref]

3- Yusuf S, Isiaku A, Abubakar A, Chinedu N, Aremu A, Samuel O, Jaji A. Harnessing extracellular vesicle-associated proteins for osteoporosis: Mechanisms, therapeutic strategies, and clinical potential. Gene Reports. 2026;42:102414 [Crossref]

4- Leng Q, Yu Z, Zhao Y, Shao Y, Jin Q, Zhao Q, Yang Y, Ji M, Yang H, Ren L, Jia G, Wang X, Zhang J, Li Z, Liu H. Targeting pre-metastatic niche with inhalable dendritic cell vesicles to prevent breast cancer lung metastasis. J Nanobiotechnol. 2025;23(1) [Crossref]

5- Soltanmohammadi F, Gharehbaba A, Zangi A, Adibkia K, Javadzadeh Y. Current knowledge of hybrid nanoplatforms composed of exosomes and organic/inorganic nanoparticles for disease treatment and cell/tissue imaging. Biomedicine & Pharmacotherapy. 2024;178:117248 [Crossref]

6- Díaz M, Simón V, Benedini L, Messina P. Redefining the Limits of Nanodevices-Based Drug Delivery Systems: Extracellular Vesicles. Pharmaceutics. 2025;17(12):1617 [Crossref]

7- Saka O, Dora D, Kibar G, Tevlek A. Expanding the role of exosomes in drug, biomolecule, and nanoparticle delivery. Life Sciences. 2025;368:123499 [Crossref]

8- Chen G, Li H, Chen R, Chen G. Exosomes as Emerging Therapeutic Strategies in Primary Osteoporosis: A Narrative Review. DDDT. 2025;Volume 19:9099 [Crossref]

9- Dieu L, Kazsoki A, Zelkó R. Drug-Loaded Extracellular Vesicle-Based Drug Delivery: Advances, Loading Strategies, Therapeutic Applications, and Clinical Challenges. Pharmaceutics. 2025;18(1):45 [Crossref]