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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2024;14(1): 48-66. doi: 10.34172/apb.2024.016
PMID: 38585451        PMCID: PMC10997935

Review Article

Lipid-Based Nanoparticles as Oral Drug Delivery Systems: Overcoming Poor Gastrointestinal Absorption and Enhancing Bioavailability of Peptide and Protein Therapeutics

Soheil Mehrdadi 1 * ORCID

Cited by CrossRef: 2

1- Molla A. Lipid Nanoparticles in Drug Delivery: Advances, Challenges, and Clinical Prospects. JDDMC. 2025;11(3):48 [Crossref]
2- Mishra A, Kumari A, Kumar P, Kumari A, Nayak M, Vishwannaath R. Lipid-Based Nanocarriers for Targeted Drug and Nutraceutical Delivery: Development, Characterization, Applications, and Industrial Challenges. J Drug Delivery Ther. 2026;16(5):153 [Crossref]
3- Mongkolnkrajang U, Kuptawach K, Sangtanoo P, Saisavoey T, Boonserm P, Reamtong O, Srimongkol P, Karnchanatat A. Bee pollen-derived peptide with dual DPP-IV Inhibition and glucose transport modulation. Sci Rep. 2026;16(1) [Crossref]
4- Chhetri P. Functional Reclassification of Lipid-Based Drug Delivery Systems and Advances in Formulation Strategies and Manufacturing Challenges. AAPS PharmSciTech. 2026;27(3) [Crossref]
5- Jose C, Gharat S, Baig A, Pilgaokar P, Momin M. Pharmacokinetic and Dissolution Profiling of Tadalafil Formulated with SNEDDS and β-Cyclodextrin in Fast-Dissolving Tablets. Drug Development and Industrial Pharmacy. 2026;:1 [Crossref]
6- Okafor N, Igbokwe N, Nnolum-Orji N, Choonara Y, Sengupta S. Polymer–Lipid Hybrid Nanosystems: An Emerging Advanced Therapeutic Tool. Advances in Polymer Technology. 2025;2025(1) [Crossref]
7- Saba N, Moniruzzaman M, Toung , Chin , La Min , Karthikeyan , Lee , Chun , Min . Insights into nanostructured lipid carriers for the effective delivery of bioactives in swine and poultry health: review. Anim Biosci. 2026;39(5):250901 [Crossref]
8- Li W, Wen C, Olatunji O, Lee C, Ashaolu T, Bose A. Debittering and Masking Soy Peptides for Oral Consumption and Immune‐Boosting Function. Journal of Food Biochemistry. 2026;2026(1) [Crossref]
9- Liu X, Zeng T, Zhang E, Bin C, Liu Q, Wu K, Luo Y, Wei S. Plant-based bioactives and oxidative stress in reproduction: anti-inflammatory and metabolic protection mechanisms. Front Nutr. 2025;12 [Crossref]
10- Serrano Mora L, Zambrano Zaragoza M, Martínez Acevedo L, García Salazar G, Flores Monroy J, Quintanar Guerrero D. Evaluation of the Cholesterol-Lowering Effect of Atorvastatin Loaded in Lipid Nanodispersions Based on Natural Materials. J Pharm Innov. 2026;21(1) [Crossref]
11- Regulagadda S, Geddam R, Vasa T, Rudhrabatla V, Gode T, Padigapati S. Fabrication of Peptide Drug Delivery Formulations and Its Characterization Techniques: A Review. Int J Pept Res Ther. 2026;32(2) [Crossref]
12- Tavares T, Carvalho I, Ramalho M, Andrade S, Pereira M, Loureiro J. Solid lipid nanoparticles as carriers for Ulva rigida peptide extract with demonstrated anti-β-amyloid and antioxidant properties. Front Aging Neurosci. 2026;18 [Crossref]
13- SAHOO U, SAHOO P, SAHOO V, SAHOO J. NANOTECHNOLOGY-DRIVEN INNOVATIONS IN HYPERTENSION MANAGEMENT: FORMULATION STRATEGIES, CHALLENGES, AND FUTURE DIRECTIONS. Asian J Pharm Clin Res. 2025;:58 [Crossref]
14- Abdollahi S, Vajhadin F, Rafiei A, Tamrin S, Daniel S, Banoei M, Zarin B, Sen A, Kim K, Sanati-Nezhad A. On-Chip modeling of drug-gut interactions in Oral drug delivery. Advanced Drug Delivery Reviews. 2026;233:115864 [Crossref]
15- 李 田. Research Progresses and Clinical Translation Prospects of Solubilization and Absorption Enhancement Oral Preparations for Poorly Water-Soluble Drugs. ACM. 2026;16(04):3927 [Crossref]
16- Veider F, To D, Saleh A, Laffleur F, Kali G, Hense D, Strube O, Bernkop-Schnürch A. Charge-converting nanocarriers: Phosphorylated polysaccharide coatings for overcoming intestinal barriers. International Journal of Biological Macromolecules. 2024;281:136308 [Crossref]
17- Chauhan R. Advancements in polymer- and lipid-based nanoparticles for enhancing drug solubility, stability, and bioavailability: an integrative and forward-looking review. Front Nanotechnol. 2026;8 [Crossref]
18- Gisela Bevilacqua Rolfsen F, Guedmiller Souza D, Ariana D, Livia Rodrigues F, Eryvaldo Socrates Tabosa D, Fábio D, Anselmo Gomes D. Dimethyl Fumarate Sterically Stabilized Solid Lipid Nanoparticles. Physicochemical properties and in vitro drug release. Int J Nanomater Nanotechnol Nanomed. 2025;11(1):015 [Crossref]