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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2015;5(2): 277-282. doi: 10.15171/apb.2015.038
PMID: 26236668        PMCID: PMC4517075

Original Research

Triamcinolone Acetonide Oromucoadhesive Paste for Treatment of Aphthous Stomatitis

Hamed Hamishehkar 1, Ali Nokhodchi 2, Saeed Ghanbarzadeh 3, Maryam Kouhsoltani 4 *

Cited by CrossRef: 29

1- Kour M, Dwivedi A. A comparative randomized clinical trial to assess the effectiveness of the diode lasers in both contact and non-contact mode and 0.1% triamcinolone acetonide mouth paste in treatment of oral ulcers—an in vivo study. Laser Dent Sci. 2020;4(1):33 [Crossref]
2- Kida D, Zakrzewska A, Zborowski J, Szulc M, Karolewicz B. Polymer-Based Carriers in Dental Local Healing—Review and Future Challenges. Materials. 2021;14(14):3948 [Crossref]
3- Surboyo M, Ernawati D, Parmadiati A. Glossitis mimicking median rhomboid glossitis induced by throat lozenges and refreshment candies. J Int Oral Health. 2019;11(5):323 [Crossref]
4- Wahyuni I, Sufiawati I, Shafuria A, Nittayananta W, Levita J. Formulation and Evaluation of Mucoadhesive Oral Care Gel Containing Kaempferia galanga Extract. Pharmaceutics. 2024;16(3):421 [Crossref]
5- Al-Maweri S, Alaizari N, Alanazi R, Ashraf S, Alanazi R, Al-Sharani H, Halboub E. Efficacy of hyaluronic acid for recurrent aphthous stomatitis: a systematic review of clinical trials. Clin Oral Invest. 2021;25(12):6561 [Crossref]
6- Sufiawati I, Siregar F, Wahyuni I, Syamsudin E. Evaluation of diode laser efficacy in treating benign oral soft tissue masses: A case series. International Journal of Surgery Case Reports. 2024;114:109075 [Crossref]
7- Rezvani Z, cheshme soltani M, Mirzadeh M, Gheibi N, Mokhlesi A, Zarabadipour M. Comparison of Two Oral Pastes Containing Triamcinolone and Rhus Coriaria L. for Treating Minor Aphthous Lesions. International Dental Journal. 2025;75(2):921 [Crossref]
8- KARINA D, SUFIAWATI I, RAMAMOORTHY V. THE EFFECTIVENESS OF MUCOADHESIVE AND MOUTHWASH THERAPY FOR ORAL MUCOSITIS WITH SYNTHETIC AND HERBAL INGREDIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS. Int J App Pharm. 2024;:29 [Crossref]
9- Ibáñez-Mancera N, López-Callejas R, Toral-Rizo V, Rodríguez-Méndez B, Lara-Carrillo E, Peña-Eguiluz R, do Amaral R, Mercado-Cabrera A, Valencia-Alvarado R. Healing of Recurrent Aphthous Stomatitis by Non-Thermal Plasma: Pilot Study. Biomedicines. 2023;11(1):167 [Crossref]
10- Çoban Ö, Özcan K, Engin S, Tatar B, Soylu M. Formulation and Evaluation of Triamcinolone Acetonide-loaded Oral Disintegrated Film with Different Polymers via Solvent Casting Method. tjps. 2023;0(0):0 [Crossref]
11- Özkahraman B, Özbaş Z, Yaşayan G, Akgüner Z, Yarımcan F, Alarçin E, Bal‐Öztürk A. Development of mucoadhesive modified kappa‐carrageenan/pectin patches for controlled delivery of drug in the buccal cavity. J Biomed Mater Res. 2022;110(4):787 [Crossref]
12- Mazzinelli E, Favuzzi I, Messina M, Fratocchi G, Vincenzoni F, Santo Stefano E, Cecconi F, Lajolo C, Basco A, Castagnola R, Cordaro M, Scilla F, Papa V, Arcovito A, Cacciotti I, Nocca G. Development of an Innovative Dual Construct for Targeted Drug Delivery in the Oral Cavity. Pharmaceutics. 2025;17(2):272 [Crossref]
13- Christopher M, Fazal A, Mehdi M, Anthoney D, Idrees Q, Javaid R. Histological evaluation of wound healing by topical phenytoin application on extraction socket: anin vivostudy in albino Wistar rats. J Oral Med Oral Surg. 2023;29(1):9 [Crossref]
14- Mortazavi H, Mashhadiabbas F, Mortazavi S, Rezaeifar K, Farhangi M. Formulation of a Jasmine Grandiflorum containing mucoadhesive and evaluation of its healing effect on oral biopsy ulcers. Clin Oral Invest. 2020;24(4):1591 [Crossref]
15- Suharyani I, Fouad Abdelwahab Mohammed A, Muchtaridi M, Wathoni N, Abdassah M. Evolution of Drug Delivery Systems for Recurrent Aphthous Stomatitis. DDDT. 2021;Volume 15:4071 [Crossref]
16- Farshforoush P, Ghanbarzadeh S, Goganian A, Hamishehkar H. Novel metronidazole-loaded hydrogel as a gastroretentive drug delivery system. Iran Polym J. 2017;26(12):895 [Crossref]
17- Yazdani-Arazi S, Ghanbarzadeh S, Adibkia K, Kouhsoltani M, Hamishehkar H. Histological evaluation of follicular delivery of arginine via nanostructured lipid carriers: a novel potential approach for the treatment of alopecia. Artificial Cells, Nanomedicine, and Biotechnology. 2017;45(7):1379 [Crossref]
18- Asgarirad H, Tehrani B, Azad bakht M, Ebrahimnejad P, Farmoudeh A, Davoodi A, Rezaeiroshan A, Hosseini S. Wound Healing Properties of Pelargonium Graveolens L'Hér Extract Lipogel: In-Vivo Evaluation in an Animal Burn Model. CDD. 2023;20(5):601 [Crossref]
19- Rosa D, Hapid M, Hidayat W. Non-Healing Chronic Traumatic Ulcer, an Entity That Can Resemble Other Chronic Ulcers. IMCRJ. 2023;Volume 16:585 [Crossref]
20- Komati S, Swain S, Rao M, Jena B, Dasi V. Mucoadhesive Multiparticulate Drug Delivery Systems: An ExtensiveReview of Patents. Adv Pharm Bull. 2019;9(4):521 [Crossref]
21- Jia B, Zhang B, Li J, Qin J, Huang Y, Huang M, Ming Y, Jiang J, Chen R, Xiao Y, Du J. Emerging polymeric materials for treatment of oral diseases: design strategy towards a unique oral environment. Chem Soc Rev. 2024;53(7):3273 [Crossref]
22- Sadeghian R, Rohani B, Golestannejad Z, Sadeghian S, Mirzaee S. Comparison of therapeutic effect of mucoadhesive nano-triamcinolone gel and conventional triamcinolone gel on oral lichen planus. Dent Res J. 2019;16(5):277 [Crossref]
23- Nakajima N, Hashimoto S, Sato H, Takahashi K, Nagoya T, Kamimura K, Tsuchiya A, Yokoyama J, Sato Y, Wakatsuki H, Miyata M, Akashi Y, Tanaka R, Matsuda K, Tabata Y, Terai S. Efficacy of gelatin hydrogels incorporating triamcinolone acetonide for prevention of fibrosis in a mouse model. Regenerative Therapy. 2019;11:41 [Crossref]
24- Donahue S, Santos Fulgencio G. PI3K Inhibitors and Adverse Events: Optimizing Patient Care for the Treatment of Advanced Breast Cancer. CJON. 2020;24(6):673 [Crossref]
25- Na W, Lim H, Jung S, Koh S. Acute Perineal Inflammation with Extensive Necrosis: A Devastating Result of Triamcinolone Acetonide Injection for Penile Augmentation. J Wound Management Res. 2017;13(2):57 [Crossref]
26- Ibrahim S, Elkot R, Soliman H. Lactic acid 5% mouth wash vs Kenalog in Orabase 0.1% for treatment and prophylaxis of recurrent aphthous ulcer. J of Cosmetic Dermatology. 2020;19(4):964 [Crossref]
27- Iadnut A, Sae-lee T, Tewtrakul S. Wound healing potential of mouth gel containing isopimarane diterpene from Kaempferia galanga rhizomes for treatment of oral stomatitis. 2024;12:e18716 [Crossref]
28- Yermak I, Davydova V, Volod’ko A. Mucoadhesive Marine Polysaccharides. Marine Drugs. 2022;20(8):522 [Crossref]
29- Georgakopoulou E, Kostakis G. TOPICAL AGENTS FOR THE PREVENTION AND TREATMENT OF ORAL MUCOSITIS. Wiad Lek. 2022;75(9):2121 [Crossref]
30- do Nascimento E, de Azevedo E, Alves-Silva M, Aragão C, Fernandes-Pedrosa M, da Silva-Junior A. Supramolecular aggregates of cyclodextrins with co-solvent modulate drug dispersion and release behavior of poorly soluble corticosteroid from chitosan membranes. Carbohydrate Polymers. 2020;248:116724 [Crossref]
31- Desai V, Shirsand S, Surampalli G. A comparative physicochemical and pharmacological evaluation of dexamethasone sodium phosphate and betamethasone sodium phosphate mucoadhesive gels for the treatment of oral submucous fibrosis in rats. Braz J Pharm Sci. 2022;58 [Crossref]
32- Sanz R, Calpena A, Mallandrich M, Gimeno Á, Halbaut L, Clares B. Development of a buccal doxepin platform for pain in oral mucositis derived from head and neck cancer treatment. European Journal of Pharmaceutics and Biopharmaceutics. 2017;117:203 [Crossref]