Adv Pharm Bull. 2019;9(2):302-306.
doi: 10.15171/apb.2019.035
  Abstract View: 33
  PDF Download: 48

Research Article

Protective Effects of Pyruvic Acid Salt Against Lithium Toxicity and Oxidative Damage in Human Blood Mononuclear Cells

Evgenii Plotnikov 1,2 * ORCiD, Innokenty Losenkov 1 ORCiD, Elena Epimakhova 1 ORCiD, Nikolay Bohan 1 ORCiD

1 Tomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute, 634014, Tomsk, Aleutskaya 4, Russia.
2 Research School of Chemistry & Applied Biomedical Sciences, Tomsk Polytechnic University, 634050, Tomsk, Lenin av., 30, Russia

Abstract

Purpose: Aim of present work was to study cytoprotective properties of lithium pyruvate, as a prospective pharmacological agent. Pyruvate has a lot of potential benefits due to positive influence on cell metabolism. Lithium is "gold-standard" mood-stabilizer. Combination of both may lead advantages.

Methods: Lithium pyruvate was tested as cytoprotector on human blood mononuclears under induced oxidative stress. Cells were obtained from healthy donors and patients with alcoholism. The detection of cell viability, apoptosis and determination of oxidative stress level were conducted by flow cytometry.

Results: Lithium pyruvate showed excellent cytoprotective properties in normal and oxidation conditions. This effect was independent from cell donor health status. It was shown on cells from healthy donors and alcoholics patients.

Conclusion: Obtained results allow considering lithium pyruvate as potential normothymic agents (mood stabilizer) with excellent cytoprotective properties.

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Submitted: 30 Sep 2018
Revised: 03 Mar 2019
Accepted: 14 Apr 2019
First published online: 01 Jun 2019
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