Abstract
Purpose:
Solid dispersions have been efficient in improving the dissolution rate and
bioavailability of hydrophobic drugs. The aim of the present study was
enhancement of the dissolution profile of Spironolactone using solid
dispersion.
Methods:
Spironolactone solid dispersions (1:1, 1:2 and 2:1 drug: carrier weight ratio)
were prepared by polyethylene glycol (PEG) 6000 as a carrier by hot melt
method. The influence of several amounts of Tween 20, 60, and 80 were also
studied. The dissolution profile was evaluated by USP Apparatus II.
Results:
The results showed that solid dispersions were efficacious to enhance the
dissolution rate of Spironolactone in water; and the procedure indicated that
there was an increase in dissolution rate for solid dispersions containing the
surfactant Tweens. The solid dispersions were evaluated using Fourier-transform
infrared (FTIR) spectroscopy, X-ray diffraction (XRD) and Differential Scanning
Calorimetry (DSC) studies; and the results showed no complex formation or
change in crystal shape of drug.
Conclusion:
It is concluded that solid dispersion technique can be successfully used for
improvement of dissolution of Spironolactone.