Mahdieh Anoush
1,2*, Mohammad Reza Mohammad Khani
11 Department of Pharmacology& Toxicology, School of Pharmacy, Zanjan University of Medical Sciences, Znjan, Iran.
2 Drug Applied Research Center, Zanjan University of Medical Sciences, Znjan, Iran.
Abstract
Purpose: As H1 and H3 receptors’ roles has been defined in
peripheral pains in some papers and because histamine is known for its role in
inflammatory responses; this study investigated the possible analgesic and
anti-inflammatory effects of ketotifen and fexofenadine as relatively safe long
acting anti histamines in both chronic chemical pain and acute inflammation in
rats.
Methods: In this study, male Sprague-Dawley rats weighing
225-250 grams were used. In order to evaluate the chemical chronic pain,
sub-plantar injection of formalin applied and the pain scores were recorded
every 15 seconds during 60 minutes. Carrageenan injection to the right hind paw
was used for induction of acute inflammation and the paw edema was measured
every 60 minutes for 4 hours.
Results: Based on the results, both ketotifen and fexofenadine
were able to significantly diminish chemical acute and chronic pain as well as
inflammation in comparison with the control group and the effects were
acceptable according to the standard treatment. Both effects for fexofenadine
started later than those of ketotifen.
Conclusion: According to the outcomes of the study, ketotifen
and fexofenadine demonstrated significant analgesic and anti-inflammatory
characteristics in both models of chemical pain and acute inflammation in
laboratory animals.