Mahmood Sadeghi Ataabadi
1, Sanaz Alaee
1*, Mohammad Jafar Bagheri
2, Soghra Bahmanpoor
21 Department of Reproductive Biology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
2 Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract
Abstract
Purpose: Given the antiandrogenic effects of spearmint, in this
study we evaluated the effects of its essential oil on polycystic ovarian
syndrome in a rat model.
Methods: Female rats were treated as follows: Control, normal
rats which received 150 mg/kg spearmint oil or 300 mg/kg spearmint oil, or
sesame oil; and PCOS-induced rats which received 150 mg/kg spearmint oil or 300
mg/kg spearmint oil, or sesame oil. Then the animals were killed and the levels
of LH, FSH, testosterone and ovarian folliculogenesis were evaluated.
Results: Spearmint oil reduced body weight, testosterone level,
ovarian cysts and atretic follicles and increased Graafian follicles in PCOS
rats.
Conclusion: Spearmint has
treatment potential on PCOS through inhibition of testosterone and restoration
of follicular development in ovarian tissue.