Adv Pharm Bull. 2017;7(4): 515-530.
doi: 10.15171/apb.2017.064
PMID: 29399542
PMCID: PMC5788207
Scopus ID: 85043382077
  Abstract View: 2310
  PDF Download: 2500

Review Article

Cross-Linked Hydrogel for Pharmaceutical Applications: A Review

Rabinarayan parhi 1*

1 GITAM Institute of Pharmacy, GITAM University, Gandhi Nagar Campus, Rushikonda, Visakhapatnam-530045, Andhra Pradesh, India.


Hydrogels are promising biomaterials because of their important qualities such as biocompatibility, biodegradability, hydrophilicity and non-toxicity. These qualities make hydrogels suitable for application in medical and pharmaceutical field. Recently, a tremendous growth of hydrogel application is seen, especially as gel and patch form, in transdermal drug delivery. This review mainly focuses on the types of hydrogels based on cross-linking and; secondly to describe the possible synthesis methods to design hydrogels for different pharmaceutical applications. The synthesis and chemistry of these hydrogels are discussed using specific pharmaceutical examples. The structure and water content in a typical hydrogel have also been discussed.
Keywords: Hydrogel, Cross-linking, Thermoreversible gel, Polymers
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Submitted: 13 Apr 2017
Revision: 13 Sep 2017
Accepted: 16 Sep 2017
ePublished: 31 Dec 2017
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