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Adv Pharm Bull. 2017;7(4): 645-650.
doi: 10.15171/apb.2017.077
PMID: 29399555
PMCID: PMC5788220
Scopus ID: 85043359158
  Abstract View: 2025
  PDF Download: 1332

Research Article

Effect of Daily Caper Fruit Pickle Consumption on Disease Regression in Patients with Non-Alcoholic Fatty Liver Disease: a Double-Blinded Randomized Clinical Trial

Narjes Khavasi 1, Mohammad hosein Somi 2, Ebrahim Khadem 3, Elnaz Faramarzi 2, Mohammad Hossein Ayati 3, Seyyed Muhammad Bagher Fazljou 1, Mohammadali Torbati 4*

1 Department of Traditional Medicine, Faculty of Traditional Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Department of liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical sciences, Tabriz, Iran.
3 Department of Traditional Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.
4 Department of Food Science and Technology, Faculty of nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
*Corresponding Author: Email: torbatima@yahoo.com

Abstract

Purpose: Despite numerous studies on the effects of complementary medicine, to our knowledge, there is no study on the effects of Capparis spinosa on disease regression in non-alcoholic fatty liver disease (NAFLD) patients. We compared the effects of caper fruit pickle consumption, as an Iranian traditional medicine product, on the anthropometric measures and biochemical parameters in different NAFLD patients. Methods: A 12-weeks randomized, controlled, double-blind trial was designed in 44 NAFLD patients randomly categorized for the control (n=22) or caper (n=22). The caper group received 40-50 gr of caper fruit pickles with meals daily. Before and after treatment, we assessed anthropometric measures, grade of fatty liver, serum lipoproteins and liver enzymes. Results: Weight and BMI were significantly decreased in the caper (p<0.001 and p<0.001) and control group (p=0.001 and p=0.001), respectively. Serum TG, TC and LDL.C just were significantly decreased in the control group (p=0.01, p<0.001 and p<0.001, respectively). Adjusted to the baseline measures, serum ALT and AST reduction were significantly higher in the caper than control group from baseline up to the end of the study (p<0.001 and p=0.02, respectively). After weeks 12, disease severity was significantly decreased in the caper group (p <0.001). Conclusion: Our results suggest that daily caper fruit pickle consumption for 12 weeks may be potentially effective on improving the biochemical parameters in NAFLD patients. Further, additional larger controlled trials are needed for the verification of these results.
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Submitted: 25 Sep 2017
Revision: 19 Dec 2017
Accepted: 21 Dec 2017
ePublished: 31 Dec 2017
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