Vinit K. Srivastava
1*, Abhishek Mishra
1, Sanjay Agrawal
2, Sanjay Kumar
3, Sunil Sharma
1, Raj Kumar
11 Apollo Hospitals Bilaspur, Chhattisgarh, India.
2 Himalayan Institute of Medical Sciences, Dehradun, India.
3 Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Abstract
Purpose: Dexmedetomidine
and magnesium sulfate have been used in anesthesia as adjuvant to provide
hemodynamic stability and anesthetic agents sparing effect. We compared these
effects of dexmedetomidine and magnesium sulfate in spine surgeries.
Methods:
Ninety patients were randomly assigned to three groups. Group D received dexmedetomidine
loading dose 1 µg/kg over a period of 15 minutes and maintenance 0.5 µg/kg/h
throughout the surgery. Group M received magnesium sulfate loading dose 50
mg/kg over a period of 15 minutes and maintenance 15 mg/kg/h throughout the
surgery. Group C received same volume of normal saline. Heart rate (HR) and
blood pressure values were recorded at various intervals. The induction and
maintenance doses of anesthetics and recovery parameters were also recorded.
Results: Heart
rate in group D and group M were significantly decreased (p<0.05) during the
whole intraoperative period compared to preoperative values. There was a
significant difference in HR values between group C, D and M, during the whole
intraoperaive period (p<0.05). Blood pressure values were statistically
significantly lower in the group D and group M compared to group C after
intubation and all time observations of surgery (p<0.05). Both drugs reduced the anesthetic
agent’s requirement during surgery. However, the recovery
parameters were statistically significant increase with magnesium sulphate
compared to dexmedetomidine and control groups.
Conclusion: Dexmedetomidine is more effective than magnesium
sulfate for maintaining the hemodynamic stability in spine surgeries. Both
these drugs also reduce the requirements of anesthetic agents. Recovery from
dexmedetomidine is as rapid as control group compared to magnesium sulfate.