The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review

Leila Azhar Shekoufeh Bahari; Hamed Hamishehkar

doi:10.15171/apb.2016.021

Adv Pharm Bull. 2016;6(2): 143-151.
doi: 10.15171/apb.2016.021

PMID: 27478775
PMCID: PMC4961971
Scopus ID: 84980390587

Abstract View: 3933

PDF Download: 3746

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The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review

Leila Azhar Shekoufeh Bahari ^1,2, Hamed Hamishehkar ²^*

¹ Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
² Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
³ Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

*Corresponding Author: Email: hamishehkar.hamed@gmail.com

Abstract

During the past decade, pharmaceutical science has seen rapid growth in interest for nanoscale materials. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are popular research topics recently introduced as nano-scale drug carriers; they have shown numerous merits in drug delivery. Size is the most important index in a nanocarrier affecting its drug delivery efficiency. The influence of preparation conditions and type of lipidic components on the size of SLN and NLC in comparable states seems to be interesting for researchers who investigate these types of carriers. This review highlights the results of SLN and NLC particle size and size distribution comparisons.

Keywords: Solid lipid nanoparticles, SLN, Nanostructured lipid carriers, NLC, Nanoparticle, Drug delivery

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PDF Download: 3746

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