Adv Pharm Bull. 2016;6(2): 243-250.
doi: 10.15171/apb.2016.033
PMID: 27478787
PMCID: PMC4961983
Scopus ID: 84980315604
  Abstract View: 3048
  PDF Download: 1565

Research Article

Vitamin C for the Prevention of Postoperative Atrial Fibrillation after Cardiac Surgery: A Meta-Analysis

Evangelos Polymeropoulos 1*, Pantelis Bagos 2, Maria Papadimitriou 3, Ioannis Rizos 4, Efstratios Patsouris 5, Ioannis Toumpoulis 6

1 Cardiology Department Red Cross Hospital, Athens, Greece.
2 Department of Computer Science and Biomedical Informatics, University of Thessaly, Lamia, Greece.
3 Internal Medicine Department, Laiko Hospital, Athens, Greece.
4 Cardiology Department, Attiko Hospital, Athens, Greece.
5 Department of Pathology, Medical School of the National University of Athens, Greece.
6 Cardiac Surgery Department, Attiko Hospital, Athens, Greece.


Purpose: Several studies have investigated the administration of vitamin C (vitC) for the prevention of postoperative atrial fibrillation (AF) after cardiac surgery. However, their findings were inconsistent. The purpose of this meta-analysis was to evaluate the efficacy of vitC as prophylaxis for the prevention of postoperative AF in cardiac surgery.

Methods: A systematic search of PubMed, EMBASE, Google Scholar, the Cochrane Library, and clinical trial registries, was performed. 9 studies, published from August 2001 to May 2015, were included, with a total of 1,037 patients. Patients were randomized to receive vitC, or placebo.

Results: Cardiac surgery patients who received vitC as prophylaxis, had a significantly lower incidence of postoperative AF (random effects OR=0.478, 95% CI 0.340 – 0.673, P < 10-4). No significant heterogeneity was detected across the analyzed studies (I2=21.7%), and no publication bias or other small study-related bias was found.

Conclusion: Our findings suggest that VitC is effective as prophylaxis for the prevention of postoperative AF. The administration of vitC may be considered in all patients undergoing cardiac surgery.

Keywords: Post-operative atrial fibrillation, Vitamin C, CABG, Valvular surgery, Cardiac surgery
First Name
Last Name
Email Address
Security code

Abstract View: 3035

Your browser does not support the canvas element.

PDF Download: 1565

Your browser does not support the canvas element.

Submitted: 24 Feb 2016
Revision: 30 May 2016
Accepted: 31 May 2016
ePublished: 29 Jun 2016
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)