Adv Pharm Bull. 2016;6(2):243-250.
doi: 10.15171/apb.2016.033
PMID: 27478787
PMCID: PMC4961983
Scopus id: 84980315604
  Abstract View: 1642
  PDF Download: 1020

Research Article

Vitamin C for the Prevention of Postoperative Atrial Fibrillation after Cardiac Surgery: A Meta-Analysis

Evangelos Polymeropoulos 1 * , Pantelis Bagos 2, Maria Papadimitriou 3, Ioannis Rizos 4, Efstratios Patsouris 5, Ioannis Toumpoulis 6

1 Cardiology Department Red Cross Hospital, Athens, Greece.
2 Department of Computer Science and Biomedical Informatics, University of Thessaly, Lamia, Greece.
3 Internal Medicine Department, Laiko Hospital, Athens, Greece.
4 Cardiology Department, Attiko Hospital, Athens, Greece.
5 Department of Pathology, Medical School of the National University of Athens, Greece.
6 Cardiac Surgery Department, Attiko Hospital, Athens, Greece.


Purpose: Several studies have investigated the administration of vitamin C (vitC) for the prevention of postoperative atrial fibrillation (AF) after cardiac surgery. However, their findings were inconsistent. The purpose of this meta-analysis was to evaluate the efficacy of vitC as prophylaxis for the prevention of postoperative AF in cardiac surgery.

Methods: A systematic search of PubMed, EMBASE, Google Scholar, the Cochrane Library, and clinical trial registries, was performed. 9 studies, published from August 2001 to May 2015, were included, with a total of 1,037 patients. Patients were randomized to receive vitC, or placebo.

Results: Cardiac surgery patients who received vitC as prophylaxis, had a significantly lower incidence of postoperative AF (random effects OR=0.478, 95% CI 0.340 – 0.673, P < 10-4). No significant heterogeneity was detected across the analyzed studies (I2=21.7%), and no publication bias or other small study-related bias was found.

Conclusion: Our findings suggest that VitC is effective as prophylaxis for the prevention of postoperative AF. The administration of vitC may be considered in all patients undergoing cardiac surgery.

First name
Last name
Email address
Security code

Article Viewed: 1642

Your browser does not support the canvas element.

PDF Downloaded: 1020

Your browser does not support the canvas element.

Submitted: 24 Feb 2016
Revised: 30 May 2016
Accepted: 31 May 2016
First published online: 29 Jun 2016
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - FireFox Plugin)