Solid Lipid Nanoparticles as Efficient Drug and Gene Delivery Systems: Recent Breakthroughs

Jafar Ezzati Nazhad Dolatabadi; Hadi Valizadeh; Hamed Hamishehkar

doi:10.15171/apb.2015.022

Adv Pharm Bull. 2015;5(2): 151-159.
doi: 10.15171/apb.2015.022

PMID: 26236652
PMCID: PMC4517084
Scopus ID: 84930406839

Abstract View: 3390

PDF Download: 2754

Original Research

Solid Lipid Nanoparticles as Efficient Drug and Gene Delivery Systems: Recent Breakthroughs

Jafar Ezzati Nazhad Dolatabadi ^1,2, Hadi Valizadeh ^3,4^*, Hamed Hamishehkar ³

¹ Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.
² Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
³ Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
⁴ Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

*Corresponding Author: Email: valizadeh@tbzmed.ac.ir

Abstract

In recent years, nanomaterials have been widely applied as advanced drug and gene delivery nanosystems. Among them, solid lipid nanoparticles (SLNs) have attracted great attention as colloidal drug delivery systems for incorporating hydrophilic or lipophilic drugs and various macromolecules as well as proteins and nucleic acids. Therefore, SLNs offer great promise for controlled and site specific drug and gene delivery. This article includes general information about SLN structures and properties, production procedures, characterization. In addition, recent progress on development of drug and gene delivery systems using SLNs was reviewed.

Keywords: Solid lipid nanoparticles, colloidal carrier, Drug delivery, Gene delivery

First Name

Last Name

Email Address

Comments

Security code

Generate New Image

Type the code from the image

Abstract View: 3391

years	Jan	Feb	Mar	Apr	May	Jun	Jul	Aug	Sep	Oct	Nov	Dec
2024	25	43	38	41
2023	23	16	20	19	18	22	20	21	24	22	16	30
2022	36	29	39	34	30	26	26	19	8	15	24	22
2021	35	24	39	42	32	48	51	39	29	38	32	39
2020	64	60	60	58	78	64	58	51	45	39	33	36
2019	32	33	39	38	40	42	42	32	41	63	43	61
2018	61	56	48	30	28	36	33	37	38	30	31	48
2017	23	22	21	20	26	28	30	25	36	28	17	38
2016				37	40	34	33	38	40	24	22	27

PDF Download: 2754

years	Jan	Feb	Mar	Apr	May	Jun	Jul	Aug	Sep	Oct	Nov	Dec
2024	9	36	34	29
2023	19	10	12	12	13	14	10	11	11	13	12	10
2022	24	23	18	22	13	10	11	6	2	10	13	17
2021	27	14	50	42	33	22	22	34	23	21	21	20
2020	34	44	45	37	40	23	32	27	41	56	30	21
2019	39	32	36	22	27	33	32	37	31	41	37	51
2018	150	162	87	50	35	32	45	27	23	31	42	28
2017	12	10	9	9	8	14	11	10	17	14	5	151
2016				22	33	23	18	19	19	9	14	14