Abstract
Purpose: This study aims to prepare a novel, natural
nanoparticle (NP) as a drug carrier, which also has inherent therapeutic
effects.
Methods: Pistacia khinjuk gum NPs were prepared and Response surface methodology
(RSM) was used for statistical analysis of data and optimizing the size of NPs.
Results: NPs
were in the range of
75.85–241.3 nm. The optimization study was carried
out, and an optimized size (70.86nm) was obtained using DMSO as a solvent. The
volume of the organic phase was 111.25µl, and the concentration of gum was 1%
w/v. The cell viability assay was performed on the pure gum and NPs
toward β-TC3, MCF7, and HT29 cell lines. It was observed that NPs
have higher cytotoxic activity in comparison with pure gum, and that the IC50value
was achieved at 1% of NPs in β-TC3 cells. The obtained NPs
demonstrated antibacterial activity against two bacterial strains (Pseudomonas
aeruginosa and Staphylococcus aureus).
Conclusion:
Altogether, according to the obtained results, these NPs with inherent
cytotoxicity and antibacterial activity are an attractive carrier for drug
delivery.