Adv Pharm Bull. 2018;8(1):39-47.
doi: 10.15171/apb.2018.005
PMID: 29670837
PMCID: PMC5896394
Scopus id: 85044048232
  Abstract View: 691
  PDF Download: 541

Research Article

Assessing the Effect of High Performance Inulin Supplementation via KLF5 mRNA Expression in Adults with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trail

Abed Ghavami 1, Neda Roshanravan 2, Shahriar Alipour 3, Meisam Barati 4, Behzad Mansoori 5, Faezeh Ghalichi 1, Elyas Nattagh- Eshtivan 1, Alireza Ostadrahimi 6 *

1 Department of Nutrition, School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Department of Molecular Medicine, Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Department of Nutrition, School of Nutrition, Shahid beheshti University of Medical Sciences, Tehran, Iran.
5 Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
6 Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract

Purpose: The worldwide prevalence of metabolic disorders such as diabetes is increasing rapidly. Currently, the complications of diabetes are the major health concern. The aim of this study was to investigate the effect of high performance (HP) inulin supplementation on glucose homeostasis via KLF5 mRNA expression in adults with type 2 diabetes. Methods: In the present clinical trial conducted for a duration of 6 weeks, 46 volunteers diabetic patients referring to diabetes clinic in Tabriz, Iran, were randomly assigned into intervention (n= 23, consuming 10 gr/ d HP inulin) and control groups (n= 23, consuming 10 gr/ d starch). We assessed glycemic and anthropometric indices, blood lipids and plasmatic level of miR-375 as well as KLF5 mRNA expression before and after the intervention. Results: Findings indicated that inulin supplementation significantly decreased fasting plasma glucose (FPG) in comparison to the placebo group (P<0.001). Also Intra-group and between group results showed that inulin supplementation resulted in significant decrease in KLF5 mRNA expression in peripheral blood mononuclear cells (PBMCs) (Fold change: 0.61± 0.11; P-value= 0.001) and significant increase in plasmatic level of miR-375 (Fold change: 3.75± 0.70; P-value=0.004). Conclusion: Considering the improvements of FPG level in diabetic patients, it seems that HP inulin supplementation may be beneficial in controlling diabetes via the expression of some genes. However, further studies are needed to achieve concise conclusions.
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Submitted: 28 Dec 2017
Revised: 17 Feb 2018
Accepted: 03 Mar 2018
First published online: 04 Mar 2018
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