Adv Pharm Bull. 2018;8(4): 565-574.
doi: 10.15171/apb.2018.065
PMID: 30607329
PMCID: PMC6311648
Scopus ID: 85057729392
  Abstract View: 2080
  PDF Download: 1132

Review Article

Effects of Prebiotic and Synbiotic Supplementation on Glycaemia and Lipid Profile in Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials

Sepideh Mahboobi 1 ORCID logo, Fatemeh Rahimi 2, Sadegh Jafarnejad 3* ORCID logo

1 Department of Community Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran.
2 Faculty of Public Health, Kermanshah University of Medical Science, Kermanshah, Iran.
3 Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
*Corresponding Author: Email: sjafarnejad@alumnus.tums.ac.ir


Purpose: Diabetes Mellitus (T2DM) as a chronic disease, is on rise in parallel with other non-communicable diseases. Several studies have shown that probiotics and prebiotics might exert beneficial effects in chronic diseases including diabetes. Because of controversial results from different trials, the present study aims to assess the effects of prebiotic/synbiotic consumption on metabolic parameters in patients with type2 diabetes. Methods: A systematic literature search was performed on randomized controlled trial published in PubMed/Medline, SciVerse Scopus, Google scholar, SID and Magiran up to March 2018. Of a total number of 255 studies found in initial literature search, ten randomized controlled trials were included in the meta-analysis. The pooled mean net change were calculated in fasting blood-glucose [FBG], Hemoglobin A1c [HbA1c] and lipid markers (total cholesterol [TC], triglyceride [TG], low-density lipoprotein cholesterol [LDL-C], high density lipoprotein cholesterol [HDL-C]). The meta-analyses was conducted using Revman Software (v5.3). Results: The pooled estimate indicated a significant difference for the mean change in FBG, HbA1c and HDL in treatment group in comparison with control group. Subgroup analysis by intervention showed a significant difference in TG, LDL and HDL (synbiotic group) and in TG, TC, FBG, HDL and HbA1c (prebiotic group) compared with placebo. In another subgroup analysis, high quality studies showed significant reductions in TG, TC, FBG and HbA1c in intervention group compared with placebo group. Conclusion: In summary, diets supplemented with either prebiotics or synbiotics can result in improvements in lipid metabolism and glucose homeostasis in type 2 diabetic patients.
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Submitted: 01 May 2018
Revision: 17 Aug 2018
Accepted: 11 Oct 2018
ePublished: 29 Nov 2018
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