Adv Pharm Bull. 2019;9(3): 432-438.
doi: 10.15171/apb.2019.051
PMID: 31592433
PMCID: PMC6773938
Scopus ID: 85070438009
  Abstract View: 407
  PDF Download: 300

Research Article

Characterization and Stability of the Antimony-Quercetin Complex

Valcilaine Teixeira Barbosa 1 ORCID logo, Janaína Barros de Menezes 1 ORCID logo, Josué Carinhanha Caldas Santos 2 ORCID logo, Maria Lysete de Assis Bastos 3 ORCID logo, João Xavier de Araújo-Júnior 1 ORCID logo, Ticiano Gomes do Nascimento 1 ORCID logo, Irinaldo Diniz Basílio-Júnior 1 ORCID logo, Luciano Aparecido Meireles Grillo 1 ORCID logo, Camila Braga Dornelas 1 * ORCID logo

1 Departamento de Farmácia, Escola de Enfermagem e Farmácia, Universidade Federal de Alagoas.
2 Instituto de Química e Biotecnologia, Universidade Federal de Alagoas.
3 Departamento de Enfermagem, Escola de Enfermagem e Farmácia, Universidade Federal de Alagoas.


Purpose: Quercetin is a flavonoid known for its therapeutic properties and for forming complexes. Although the antimony-quercetin (SbQ) complex has been produced before, no previous exploration of its characteristics has been published in literature. Thus, this study aimed to characterize this complex, assess its stability and investigate its complexation site through its antibacterial activity.

Methods: The SbQ complex was synthetized using Sb(III) potassium tartrate trihydrate and quercetin anhydrous (1:1) (v/v) as a solution and dried using three methods: rotaevaporation, lyophilization and spray drying. The material, in solution, was analyzed by UV-vis and fluorimetry; and, in the powder, by X-ray diffraction (XRD), both scanning electronic and fluorescence microscopy and infrared spectroscopy (FT-IR). Antimicrobial activity was evaluated via broth microdilution.

Results: UV-vis exhibited a shoulder peak at 291 nm indicating metal chelation at C-ring of quercetin and confirmed 1:1 stoichiometry. Spectrofluorimetry showed an increase of intensity with the complex formation with an emission band (525 nm). After drying, XRD and SEM indicated loss of crystallinity and a difference in shape and size of the complex compared to its precursors. FT-IR suggested by a shift of frequency of the carbonyl group (1661 cm-1) that the quercetin bond to antimony by the C-3, followed by positions C-5 and C-4 carbonyl, which has been confirmed by MIC through the structure-activity relationship of the antibacterial activity of quercetin.

Conclusion: These results provided a characterization of SbQ complex with the confirmation of its binding site, working as a guide for future studies involving this complex.

Keywords: Antimony, Binding sites, Flavonoids, Quercetin
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Submitted: 31 Aug 2018
Revision: 05 Jan 2019
Accepted: 02 May 2019
ePublished: 01 Aug 2019
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