Adv Pharm Bull. 2019;9(3):382-392.
doi: 10.15171/apb.2019.045
  Abstract View: 28
  PDF Download: 46

Research Article

Assessment of the Effect of PLGA Co-polymers and PEG on the Formation and Characteristics of PLGA-PEG-PLGA Co-block PolymerUsing Statistical Approach

Teuku Nanda Saifullah Sulaiman 1, Dwi Larasati 2, Akhmad Kharis Nugroho 1, Syaiful Choiri 3 * ORCiD

1 Department of Pharmaceutics, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, Indonesia 55281.
2 Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, Indonesia 55281.
3 Pharmaceutical Technology and Drug Delivery, Department of Pharmacy, Universitas Sebelas Maret, Ir. Sutami 36A, Surakarta, Indonesia, 57126.


Purpose: To assess the effect of the lactic acid (LA)-to-glycolic acid (GA) molar ratio andpolyethylene glycol (PEG) concentration on the formation of poly-lactide co-glycolide acid(PLGA)-PEG-PLGA co-block polymers simultaneously using statistical approach.Methods: A 22 full factorial design with the addition of a point in the center of the design, namelycurvature, was applied. Fourier transform infrared (FTIR), differential scanning calorimetry(DSC), and nuclear magnetic resonance (NMR) were performed to confirm the formation of theco-block polymer. Simvastatin (SMV), a drug model was incorporated into the nano-polymericmicellar (NpM) of PLGA-PEG-PLGA followed by solubility phase, particle size, zeta potential,and entrapment efficiency characterizations.Results: FTIR, DSC, and NMR successfully confirmed the formation of co-block polymers.Solubility of SMV increased from 2 to 44-folds depending on co-block concentration withentrapment efficiency of 59%-80%. The NpM had size in the range of 206 to 402 nm withnegative zeta potential. LA to GA ratio had greater effect on particle size reduction and increasingof co-polymer length. In addition, it had higher contributions on increasing of solubility andentrapment efficiency of SMV than PEG.Conclusion: According to these findings, the LA to GA ratio and PEG concentration gained agreat consideration in order to prepare the PLGA-PEG-PLGA co-block which fulfilled the qualitytarget product profile of NpM delivery system.
First name
Last name
Email address
Security code

Article Viewed: 28

Your browser does not support the canvas element.

PDF Downloaded: 46

Your browser does not support the canvas element.

Submitted: 25 Oct 2018
Revised: 20 Apr 2019
Accepted: 20 May 2019
First published online: 01 Aug 2019
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - FireFox Plugin)