Adv Pharm Bull. 2019;9(3):360-373.
doi: 10.15171/apb.2019.043
  Abstract View: 34
  PDF Download: 53

Review Article

The Potential of Magnetic Nanoparticles for Diagnosis and Treatmentof Cancer Based on Body Magnetic Field and Organ-on-the-Chip

Ali Alirezaie Alavijeh ORCiD, Mohamd Barati * ORCiD, Meisam Barati ORCiD, Hussein Abbasi Dehkordi ORCiD

1 Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.
2 Department of Applied Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Iran.
3 Student Research Committee, Department of Cellular and Molecular Nutrition, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

Cancer is an abnormal cell growth which tends to proliferate in an uncontrolled way and, insome cases, leads to metastasis. If cancer is left untreated, it can immediately cause death. Theuse of magnetic nanoparticles (MNPs) as a drug delivery system will enable drugs to targettissues and cell types precisely. This study describes usual strategies and consideration for thesynthesis of MNPs and incorporates payload drug on MNPs. They have advantages such asvisual targeting and delivering which will be discussed in this review. In addition, we consideredbody magnetic field to make drug delivery process more effective and safer by the applicationof MNPs and tumor-on-chip.
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Submitted: 17 Dec 2018
Revised: 18 May 2019
Accepted: 20 May 2019
First published online: 01 Aug 2019
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