Logo-apb
Adv Pharm Bull. 2019;9(4): 510-520.
doi: 10.15171/apb.2019.061
PMID: 31857956
PMCID: PMC6912174
Scopus ID: 85075838438
  Abstract View: 1609
  PDF Download: 801

Review Article

Current Biochemical Applications and Future Prospects of Chlorotoxin in Cancer Diagnostics and Therapeutics

Sbonelo Khanyile 1 ORCID logo, Priscilla Masamba 1 ORCID logo, Babatunji Emmanuel Oyinloye 1,2 ORCID logo, Londiwe Simphiwe Mbatha 1, Abidemi Paul Kappo 1* ORCID logo

1 Biotechnology and Structural Biology (BSB) Group, Department of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Zululand, KwaDlangezwa 3886, South Africa.
2 Department of Biochemistry, College of Sciences, Afe Babalola University, PMB 5454, Ado-Ekiti 360001, Nigeria.
*Corresponding Author: Email: KappoA@unizulu.ac.za

Abstract

Chlorotoxin (CTX) is a minute 4 kDa protein made up of 36 amino acid residues, commonly known for its binding affinity to chloride channels and matrix metalloproteinase-2 (MMP-2) of glioma tumors of the spine and brain. This property and the possibility of conjugating this peptide to nanoparticles have enabled its diverse use in various biotechnological and biomedical applications for cancer treatment, such as in tumor imaging and radiotherapy. Because of the fascinating biological properties CTX possesses, elucidating its mechanism of action may hold promise for the development of new and effective therapeutic drugs, as well as more sensitive and highly specific cancer-screening kits. This article therefore reviews the currently known applications of CTX and suggests diverse ways in which it can be applied for the design of improved drugs and diagnostic tools for cancer.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 1609

Your browser does not support the canvas element.


PDF Download: 801

Your browser does not support the canvas element.

Submitted: 29 Apr 2019
Revision: 14 Jul 2019
Accepted: 21 Jul 2019
ePublished: 24 Oct 2019
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)