Adv Pharm Bull. 2019;9(4): 510-520.
doi: 10.15171/apb.2019.061
PMID: 31857956
PMCID: PMC6912174
Scopus ID: 85075838438
  Abstract View: 2071
  PDF Download: 1021

Review Article

Current Biochemical Applications and Future Prospects of Chlorotoxin in Cancer Diagnostics and Therapeutics

Sbonelo Khanyile 1 ORCID logo, Priscilla Masamba 1 ORCID logo, Babatunji Emmanuel Oyinloye 1,2 ORCID logo, Londiwe Simphiwe Mbatha 1, Abidemi Paul Kappo 1* ORCID logo

1 Biotechnology and Structural Biology (BSB) Group, Department of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Zululand, KwaDlangezwa 3886, South Africa.
2 Department of Biochemistry, College of Sciences, Afe Babalola University, PMB 5454, Ado-Ekiti 360001, Nigeria.
*Corresponding Author: Email: KappoA@unizulu.ac.za


Chlorotoxin (CTX) is a minute 4 kDa protein made up of 36 amino acid residues, commonly known for its binding affinity to chloride channels and matrix metalloproteinase-2 (MMP-2) of glioma tumors of the spine and brain. This property and the possibility of conjugating this peptide to nanoparticles have enabled its diverse use in various biotechnological and biomedical applications for cancer treatment, such as in tumor imaging and radiotherapy. Because of the fascinating biological properties CTX possesses, elucidating its mechanism of action may hold promise for the development of new and effective therapeutic drugs, as well as more sensitive and highly specific cancer-screening kits. This article therefore reviews the currently known applications of CTX and suggests diverse ways in which it can be applied for the design of improved drugs and diagnostic tools for cancer.
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Submitted: 29 Apr 2019
Revision: 14 Jul 2019
Accepted: 21 Jul 2019
ePublished: 24 Oct 2019
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