Adv Pharm Bull. 2020;10(2): 150-165.
doi: 10.34172/apb.2020.021
PMID: 32373485
PMCID: PMC7191226
Scopus ID: 85082938452
  Abstract View: 890
  PDF Download: 737

Review Article

Nanostructured Lipid Carriers: A Groundbreaking Approach for Transdermal Drug Delivery

Iti Chauhan 1* ORCID logo, Mohd Yasir 2, Madhu Verma 1, Alok Pratap Singh 1

1 Department of Pharmaceutics, I.T.S College of Pharmacy, Muradnagar, Ghaziabad- 201206, Uttar Pradesh, India.
2 Department of Pharmacy, College of Health Science, Arsi University, Asella, Oromia Region, Ethiopia.


Nanostructured lipid carriers (NLCs) are novel pharmaceutical formulations which are composed of physiological and biocompatible lipids, surfactants and co-surfactants. Over time, as a second generation lipid nanocarrier NLC has emerged as an alternative to first generation nanoparticles. This review article highlights the structure, composition, various formulation methodologies, and characterization of NLCs which are prerequisites in formulating a stable drug delivery system. NLCs hold an eminent potential in pharmaceuticals and cosmetics market because of extensive beneficial effects like skin hydration, occlusion, enhanced bioavailability, and skin targeting. This article aims to evoke an interest in the current state of art NLC by discussing their promising assistance in topical drug delivery system. The key attributes of NLC that make them a promising drug delivery system are ease of preparation, biocompatibility, the feasibility of scale up, non-toxicity, improved drug loading, and stability.
Keywords: Nanostructure lipid carrier, Lipid, Topical, Skin
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Submitted: 08 May 2019
Revision: 15 Oct 2019
Accepted: 17 Oct 2019
ePublished: 18 Feb 2020
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