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Adv Pharm Bull. 2019;9(4): 685-689.
doi: 10.15171/apb.2019.080
PMID: 31857975
PMCID: PMC6912173
Scopus ID: 85075838080
  Abstract View: 984
  PDF Download: 665

Short Communication

10-Gingerol Inhibits Ovarian Cancer Cell Growth by Inducing G2 Arrest

Andrea Rasmussen 1 ORCID logo, Kaylee Murphy 2, David W. Hoskin 1,2,3* ORCID logo

1 Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.
2 Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.
3 Department of Surgery, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.
*Corresponding Author: Department of Surgery, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada. Email d.w.hoskin@dal.ca
*Corresponding Author: Email: d.w.hoskin@dal.ca

Abstract

Purpose: Gingerol homologs found in the rhizomes of ginger plants have the potential to benefit human health, including the prevention and treatment of cancer. This study evaluated the effect of 10-gingerol on ovarian cancer cell (HEY, OVCAR3, and SKOV-3) growth.

Methods: Cell growth was measured by MTT assays, flow cytometry was used to assess cell proliferation, cytotoxicity and cell cycle progression, and western blotting was used to measure cyclin protein expression.

Results: Ovarian cancer cells that were treated with 10-gingerol experienced a time- and dose-dependent decrease in cell number, which was due to a reduction in cell proliferation rather than a cytotoxic effect. Reduced proliferation of 10-gingerol-treated ovarian cancer cells was associated with an increased percentage of cells in G2 phase of the cell cycle and a corresponding reduction in the percentage of cells in G1. Ovarian cancer cells also showed decreased cyclin A, B1, and D3 expression following exposure to 10-gingerol.

Conclusion: These findings revealed that 10-gingerol caused a G2 arrest-associated suppression of ovarian cancer cell growth, which may be exploited in the management of ovarian cancer.


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Submitted: 21 May 2019
Revision: 14 Jun 2019
Accepted: 21 Jul 2019
ePublished: 24 Oct 2019
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