Adv Pharm Bull. 2020;10(3): 370-378.
doi: 10.34172/apb.2020.045
  Abstract View: 74
  PDF Download: 79

Review Article

Medicinal Plants Extracts with Antiangiogenic Activity: Where Is theLink?

Zohreh Hoseinkhani 1 ORCID logo, Fathemeh Norooznezhad 1, Mohsen Rastegari-Pouyani 2, Kamran Mansouri 1 * ORCID logo

1 Medical Biology Research Center Medical Sciences, Health Technology Institute, Kermanshah, Iran.
2 Student Research Committee, Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


Angiogenesis is a strictly controlled process defined as the formation of new blood vesselsessential for certain physiologic and pathologic conditions where the latter includes tumorgrowth, development, and metastasis. Thus, inhibiting angiogenesis along with other anticancerstrategies such as chemotherapy seems to be invaluable for reaching an optimal outcome incancer patients. It has been shown that some natural plant-derived compounds are capableof preventing the formation of these new blood vessels in the tumor and also inhibit theproliferation and growth of the cancer cells. In this review, we intend to introduce plants withanti-angiogenic properties and discuss their related features.
Keywords: Angiogenesis, Plant extract, Natural compounds, Chemotherapy
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Submitted: 04 Aug 2019
Revision: 08 Dec 2019
Accepted: 29 Dec 2019
ePublished: 11 May 2020
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