Adv Pharm Bull. 2020;10(3): 370-378.
doi: 10.34172/apb.2020.045
PMID: 32665895
PMCID: PMC7335987
Scopus ID: 85088615167
  Abstract View: 693
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Review Article

Medicinal Plants Extracts with Antiangiogenic Activity: Where Is the Link?

Zohreh Hoseinkhani 1 ORCID logo, Fathemeh Norooznezhad 1, Mohsen Rastegari-Pouyani 2, Kamran Mansouri 1* ORCID logo

1 Medical Biology Research Center Medical Sciences, Health Technology Institute, Kermanshah, Iran.
2 Student Research Committee, Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
*Corresponding Author: Kamran Mansouri, Tel: +98 8334276473; Fax: +98 8334276471, Email: kmansouri@kums.ac.ir


Angiogenesis is a strictly controlled process defined as the formation of new blood vessels essential for certain physiologic and pathologic conditions where the latter includes tumor growth, development, and metastasis. Thus, inhibiting angiogenesis along with other anticancer strategies such as chemotherapy seems to be invaluable for reaching an optimal outcome in cancer patients. It has been shown that some natural plant-derived compounds are capable of preventing the formation of these new blood vessels in the tumor and also inhibit the proliferation and growth of the cancer cells. In this review, we intend to introduce plants with anti-angiogenic properties and discuss their related features.
Keywords: Angiogenesis, Plant extract, Natural compounds, Chemotherapy
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Submitted: 04 Aug 2019
Revision: 08 Dec 2019
Accepted: 29 Dec 2019
ePublished: 11 May 2020
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