Arezo Azari
1 
, Ali Golchin
2,3* , Maryam Mahmoodinia Maymand
4 , Fatemeh Mansouri
5,6 , Abdolreza Ardeshirylajimi
7,8 1 Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Department of Clinical Biochemistry and Applied Cell Sciences, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
3 Regenerative Medicine Group (REMED), Universal Scientific Education and Research Network (USERN), Urmia, Iran.
4 Cell Therapy Center, Sarem Women’s Hospital, Tehran, Iran.
5 Department of Genetics and Immunology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
6 Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran.
7 Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
8 SinaCell Research and Product Center, Tehran, Iran.
Abstract
Unique mechanical properties, miscibility potency, and biodegradability are the threeprominent features of polycaprolactone (PCL), making it an attractive biomaterial whichcommonly applied in regenerative medicine and biomedical engineering. Different strategiesdeveloped for fabricating nanofibrous construct, electrospinning is a practical, simple, andefficient technique based on electro-hydrodynamic systems that use an electrified viscousfluid jet drawn by the air toward a collector at a changing electric potential. PCL electrospunbasednanofibrous composites as proper scaffolds are employed in stem cell-related research,particularly in tissue engineering, wound dressing, and systems designed for sending drugs.A compilation of mechanochemical properties and most common biological performance onPCL-based electrospun fibrous structures in biomedical application are included in this study.Therefore, electrospun PCL nanofiber applying has been presented, and after that, currentprogress and prospects have been discussed. Literature reviews revealed that electrospun PCLnanofibrous composites had gained significant attention in regenerative medicine, and thesestructures have shown notable development in mechanobiological properties. This evidence isa crucial success for biomedical strategies, especially in regenerative medicine.