naseh abdollahzade
* 
, Peyvand Bahramiazar, Bakhtyar Tartibian, Naser Ahmadiasl, Fakhreddin Yaghoob Nezhad
Abstract
Brain disorders are global health issues and cause mortality and morbidity. Experimental data have shown that the rate of cognitive impairments in the reproductive age is lower in women than men, which refers to the importance of sex hormones in the brain. Estrogen as a sex hormone has a protective effect on the central nervous system (1) diseases and its role is changed by aging. Estrogenic hormonal activity affects brain function through their specific estrogen receptors to promote the expression of target gene changes at the transcriptional level. miRNAs regulate gene expression via inhibiting translational processes and have been estimated to be involved in regulating almost 30% of all protein-coding genes in mammals. Our review highlights the present knowledge about the role of estrogen-sensitive miRNAs and their efficacy in regulating brain functions and disorders.