Logo-apb
Adv Pharm Bull. 2021;11(2): 212-223.
doi: 10.34172/apb.2021.025
PMID: 33880343
PMCID: PMC8046397
Scopus ID: 85103208041
  Abstract View: 1764
  PDF Download: 891
  Full Text View: 382

Review Article

Main Approaches to Enhance Radiosensitization in Cancer Cells by Nanoparticles: A Systematic Review

Behnaz Babaye Abdollahi 1,2,3 ORCID logo, Reza Malekzadeh 2, Fatemeh Pournaghi Azar 4 ORCID logo, Fatemeh Salehnia 5, Ali Reza Naseri 6, Marjan Ghorbani 7 ORCID logo, Hamed Hamishehkar 1 ORCID logo, Ali Reza Farajollahi 1,2,6* ORCID logo

1 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Department of Medical Physics, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Department of Operative Density, Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
5 Research Center for Evidence Based Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
6 Imam Reza Educational Hospital, Radiotherapy Department, Tabriz University of Medical Sciences, Tabriz, Iran.
7 Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
*Corresponding Author: Imam Reza Educational Hospital, Radiotherapy Department, Tabriz University of Medical Sciences, Tabriz, Iran. Email farajollahia@tbzmed.ac.ir
*Corresponding Author: *Corresponding Author: Ali Reza Farajollahi, Tel/Fax: +984133364660, Email: , Email: farajollahia@tbzmed.ac.ir

Abstract

In recent years, high atomic number nanoparticles (NPs) have emerged as promising radio-enhancer agents for cancer radiation therapy due to their unique properties. Multi-disciplinary studies have demonstrated the potential of NPs-based radio-sensitizers to improve cancer therapy and tumor control at cellular and molecular levels. However, studies have shown that the dose enhancement effect of the NPs depends on the beam energy, NPs type, NPs size, NPs concentration, cell lines, and NPs delivery system. It has been believed that radiation dose enhancement of NPs is due to the three main mechanisms, but the results of some simulation studies failed to comply well with the experimental findings. Thus, this study aimed to quantitatively evaluate the physical, chemical, and biological factors of the NPs. An organized search of PubMed/Medline, Embase, ProQuest, Scopus, Cochrane and Google Scholar was performed. In total, 77 articles were thoroughly reviewed and analyzed. The studies investigated 44 different cell lines through 70 in-vitro and 4 in-vivo studies. A total of 32 different types of single or core-shell NPs in different sizes and concentrations have been used in the studies.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 1765

Your browser does not support the canvas element.


PDF Download: 891

Your browser does not support the canvas element.


Full Text View: 382

Your browser does not support the canvas element.

Submitted: 19 Feb 2020
Revision: 01 Jun 2020
Accepted: 13 Jul 2020
ePublished: 13 Jul 2020
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)